SwePub
Sök i LIBRIS databas

  Extended search

WFRF:(Ekström Eva Charlotte)
 

Search: WFRF:(Ekström Eva Charlotte) > Arsenic Exposure Af...

  • Ahmed, SultanCentre for Vaccine Sciences, International Centre for Diarrhoeal Disease Research, Bangladesh (ICDDR,B), Dhaka (author)

Arsenic Exposure Affects Plasma Insulin-Like Growth Factor 1 (IGF-1) in Children in Rural Bangladesh

  • Article/chapterEnglish2013

Publisher, publication year, extent ...

  • 2013-11-26
  • Public Library of Science (PLoS),2013
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-213923
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-213923URI
  • https://doi.org/10.1371/journal.pone.0081530DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:127855316URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Background: Exposure to inorganic arsenic (As) through drinking water during pregnancy is associated with lower birth size and child growth. The aim of the study was to assess the effects of As exposure on child growth parameters to evaluate causal associations. Methodology/Findings: Children born in a longitudinal mother-child cohort in rural Bangladesh were studied at 4.5 years (n=640) as well as at birth (n=134). Exposure to arsenic was assessed by concurrent and prenatal (maternal) urinary concentrations of arsenic metabolites (U-As). Associations with plasma concentrations of insulin-like growth factor 1 (IGF-1), calcium (Ca), vitamin D (Vit-D), bone-specific alkaline phosphatase (B-ALP), intact parathyroid hormone (iPTH), and phosphate (PO4) were evaluated by linear regression analysis, adjusted for socioeconomic factor, parity and child sex. Child U-As (per 10 mu g/L) was significantly inversely associated with concurrent plasma IGF-1 (beta=-0.27; 95% confidence interval: -0.50, -0.0042) at 4.5 years. The effect was more obvious in girls (beta=-0.29; -0.59, 0.021) than in boys, and particularly in girls with adequate height (beta=-0.491; -0.97, -0.02) or weight (beta=-0.47; 0.97, 0.01). Maternal U-As was inversely associated with child IGF-1 at birth (r=-0.254, P=0.003), but not at 4.5 years. There was a tendency of positive association between U-As and plasma PO4 in stunted boys (beta=0.27; 0.089, 0.46). When stratified by % monomethylarsonic acid (MMA, arsenic metabolite) (median split at 9.7%), a much stronger inverse association between U-As and IGF-1 in the girls (beta=-0.41; -0.77, -0.03) was obtained above the median split. Conclusion: The results suggest that As-related growth impairment in children is mediated, at least partly, through suppressed IGF-1 levels.

Added entries (persons, corporate bodies, meetings, titles ...)

  • Rekha, Rokeya SultanaKarolinska Institutet (author)
  • Bin Ahsan, KhalidCentre for Vaccine Sciences, International Centre for Diarrhoeal Disease Research, Bangladesh (ICDDR,B), Dhaka (author)
  • Doi, MarikoDepartment of Clinical Trial and Clinical Epidemiology, Faculty of Medicine, University of Tsukuba, Japan (author)
  • Grander, MargarethaKarolinska Institutet (author)
  • Roy, Anjan KumarCentre for Vaccine Sciences, International Centre for Diarrhoeal Disease Research, Bangladesh (ICDDR,B), Dhaka (author)
  • Ekström, Eva-Charlotte,1956-Uppsala universitet,Institutionen för kvinnors och barns hälsa,Internationell sexuell och reproduktiv hälsa/Larsson(Swepub:uu)loeks254 (author)
  • Wagatsuma, YukikoDepartment of Clinical Trial and Clinical Epidemiology, Faculty of Medicine, University of Tsukuba, Japan (author)
  • Vahter, MarieKarolinska Institutet (author)
  • Raqib, RubhanaCentre for Vaccine Sciences, International Centre for Diarrhoeal Disease Research, Bangladesh (ICDDR,B), Dhaka (author)
  • Karolinska InstitutetCentre for Vaccine Sciences, International Centre for Diarrhoeal Disease Research, Bangladesh (ICDDR,B), Dhaka (creator_code:org_t)

Related titles

  • In:PLOS ONE: Public Library of Science (PLoS)8:11, s. e81530-1932-6203

Internet link

Find in a library

  • PLOS ONE (Search for host publication in LIBRIS)

To the university's database

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view