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Octreotide and inte...
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Tiensuu Janson, EvaUppsala universitet,Institutionen för medicinska vetenskaper,Onkologisk endokrinologi
(författare)
Octreotide and interferon alfa : a new combination for the treatment of malignant carcinoid tumours
- Artikel/kapitelEngelska1992
Förlag, utgivningsår, omfång ...
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-21438
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-21438URI
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Språk:engelska
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Sammanfattning på:engelska
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Klassifikation
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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24 patients with malignant carcinoid tumours received octreotide and interferon alfa (IFN-alpha). All the patients initially received octreotide 50-100 micrograms, twice daily. When progressive symptoms or increasing biochemical markers were observed, the daily dose was raised to a median 300 micrograms. If the initial dose proved ineffective or if no improvement was seen after escalation, IFN-alpha was added (median 9 MU subcutaneously per week). After the addition of IFN-alpha, 17 of the 22 patients (77%) with elevated urinary 5-hydroxyindoleacetic acid showed a significant (> 50%) reduction. Only 1 patient progressed and 4 had continuously stable biochemical disease. No significant reduction in tumour size was noted; in 5 patients, the tumour continued to grow despite decreasing hormone levels. 18 patients had carcinoid syndrome when IFN-alpha was added in 10 (56%) symptoms ameliorated. Thus, the addition of IFN-alpha is beneficial for patients with malignant carcinoid tumours that progress and/or who do not respond to octreotide.
Ämnesord och genrebeteckningar
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Adult
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Aged
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Antineoplastic Combined Chemotherapy Protocols/*therapeutic use
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Female
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Humans
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Hydroxyindoleacetic Acid/urine
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Interferon-alpha/therapeutic use
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Male
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Malignant Carcinoid Syndrome/mortality/*therapy/urine
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Middle Aged
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Octreotide/therapeutic use
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Ahlström, HåkanUppsala universitet,Enheten för radiologi
(författare)
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Andersson, T
(författare)
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Öberg, KjellUppsala universitet,Institutionen för medicinska vetenskaper,Onkologisk endokrinologi
(författare)
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Uppsala universitetInstitutionen för medicinska vetenskaper
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:European Journal of Cancer28A:10, s. 1647-16500959-80491879-0852
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