WFRF:(Speedy Helen E.)
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- Speedy, Helen E. (author)
A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia
- Article/chapterEnglish2014
Publisher, publication year, extent ...
- 2013-12-01
- Springer Science and Business Media LLC,2014
- printrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:uu-216735
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-216735URI
- https://doi.org/10.1038/ng.2843DOI
- https://lup.lub.lu.se/record/4225448URI
- http://kipublications.ki.se/Default.aspx?queryparsed=id:128003913URI
- https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-85627URI
Supplementary language notes
- Language:English
- Summary in:English
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- SwePubSwePub
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Notes
- Genome-wide association studies (GWAS) of chronic lymphocytic leukemia (CLL) have shown that common genetic variation contributes to the heritable risk of CLL. To identify additional CLL susceptibility loci, we conducted a GWAS and performed a meta-analysis with a published GWAS totaling 1,739 individuals with CLL (cases) and 5,199 controls with validation in an additional 1,144 cases and 3,151 controls. A combined analysis identified new susceptibility loci mapping to 3q26.2 (rs10936599, P = 1.74 x 10(-9)), 4q26 (rs6858698, P = 3.07 x 10(-9)), 6q25.2 (IPCEF1, rs2236256, P = 1.50 x 10(-10)) and 7q31.33 (POT1, rs17246404, P = 3.40 x 10(-8)). Additionally, we identified a promising association at 5p15.33 (CLPTM1L, rs31490, P = 1.72 x 10(-7)) and validated recently reported putative associations at 5p15.33 (TERT, rs10069690, P = 1.12 x 10(-10)) and 8q22.3 (rs2511714, P = 2.90 x 10(-9)). These findings provide further insights into the genetic and biological basis of inherited genetic susceptibility to CLL.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Cell- och molekylärbiologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Cell and Molecular Biology hsv//eng
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Medicinsk genetik hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Medical Genetics hsv//eng
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Cancer och onkologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Cancer and Oncology hsv//eng
Added entries (persons, corporate bodies, meetings, titles ...)
- Di Bernardo, Maria Chiara (author)
- Sava, Georgina P. (author)
- Dyer, Martin J. S. (author)
- Holroyd, Amy (author)
- Wang, Yufei (author)
- Sunter, Nicola J. (author)
- Mansouri, LarryUppsala universitet,Hematologi och immunologi(Swepub:uu)maman377 (author)
- Juliusson, GunnarLund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)stem-gju (author)
- Smedby, Karin E.Karolinska Institutet (author)
- Roos, GöranUmeå universitet,Patologi(Swepub:umu)goro0001 (author)
- Jayne, Sandrine (author)
- Majid, Aneela (author)
- Dearden, Claire (author)
- Hall, Andrew G. (author)
- Mainou-Fowler, Tryfonia (author)
- Jackson, Graham H. (author)
- Summerfield, Geoffrey (author)
- Harris, Robert J. (author)
- Rosenquist, RichardUppsala universitet,Hematologi och immunologi(Swepub:uu)richrose (author)
- Allsup, David J. (author)
- Bailey, James R. (author)
- Pratt, Guy (author)
- Pepper, Chris (author)
- Fegan, Chris (author)
- Rosenquist, RichardUppsala universitet,Hematologi och immunologi(Swepub:uu)richrose (author)
- Catovsky, Daniel (author)
- Allan, James M. (author)
- Houlston, Richard S. (author)
- Uppsala universitetHematologi och immunologi (creator_code:org_t)
Related titles
- In:Nature Genetics: Springer Science and Business Media LLC46:1, s. 56-+1061-40361546-1718
Internet link
- http://sro.sussex.ac.uk/id/eprint/74717/4/Final_manuscript_NG-LE36513R_w_figures.pdf
- http://www.ncbi.nlm.nih.gov/pubmed/24292274?dopt=AbstractFULLTEXT
- http://dx.doi.org/10.1038/ng.2843FULLTEXT
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-216735
- https://doi.org/10.1038/ng.2843
- https://lup.lub.lu.se/record/4225448
- http://kipublications.ki.se/Default.aspx?queryparsed=id:128003913
- https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-85627
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