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Metastatic type 1 g...
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Grozinsky-Glasberg, Simona
(author)
Metastatic type 1 gastric carcinoid : A real threat or just a myth?
- Article/chapterEnglish2013
Publisher, publication year, extent ...
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Baishideng Publishing Group Inc.2013
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-217638
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-217638URI
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https://doi.org/10.3748/wjg.v19.i46.8687DOI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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AIM:To describe disease characteristics and treatment modalities in a group of rare patients with metastatic gastric carcinoid type 1 (GCA1).METHODS:Information on clinical, biochemical, radiological, histopathological findings, the extent of the disease, as well as the use of different therapeutic modalities and the long-term outcome were recorded. Patients' data were assessed at presentation, and thereafter at 6 to 12 monthly intervals both clinically and biochemically, but also endoscopically and histopathologically. Patients were evaluated for the presence of specific symptoms; the presence of autoimmune disorders and the presence of other gastrointestinal malignancies in other family members were also recorded. The evaluation of response to treatment was defined using established WHO criteria.RESULTS:We studied twenty consecutive patients with a mean age of 55.1 years. The mean follow-up period was 83 mo. Twelve patients had regional lymph node metastases and 8 patients had liver metastases. The primary tumor mean diameter was 20.13 +/- 10.83 mm (mean +/- SD). The mean Ki-67 index was 6.8% +/- 11.2%. All but one patient underwent endoscopic or surgical excision of the tumor. The disease was stable in all but 3 patients who had progressive liver disease. All patients remained alive during the follow-up period.CONCLUSION: Metastatic GCA1 carries a good overall prognosis, being related to a tumor size of >= 1 cm, an elevated Ki-67 index and high serum gastrin levels. (C) 2013 Baishideng Publishing Group Co., Limited. All rights reserved.
Subject headings and genre
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Metastatic gastric carcinoids
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Gastrin
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Chromogranin A
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Somatostatin analogues
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Stomach neuroendocrine tumor
Added entries (persons, corporate bodies, meetings, titles ...)
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Thomas, Dimitrios
(author)
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Strosberg, Jonathan R.
(author)
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Pape, Ulrich-Frank
(author)
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Felder, Stephan
(author)
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Tsolakis, Apostolos V.Uppsala universitet,Onkologisk endokrinologi(Swepub:uu)aptso227
(author)
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Alexandraki, Krystallenia I.
(author)
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Fraenkel, Merav
(author)
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Saiegh, Leonard
(author)
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Reissman, Petachia
(author)
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Kaltsas, Gregory
(author)
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Gross, David J.
(author)
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Uppsala universitetOnkologisk endokrinologi
(creator_code:org_t)
Related titles
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In:World Journal of Gastroenterology: Baishideng Publishing Group Inc.19:46, s. 8687-86951007-93272219-2840
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