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Sökning: id:"swepub:oai:DiVA.org:uu-220558" > Long-term outcomes ...

  • Edelvik, Anna (författare)

Long-term outcomes of epilepsy surgery in Sweden A national prospective and longitudinal study

  • Artikel/kapitelEngelska2013

Förlag, utgivningsår, omfång ...

  • 2013
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:uu-220558
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-220558URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Objective: To investigate prospective, population-based long-term outcomes concerning seizures and antiepileptic drug (AED) treatment after resective epilepsy surgery in Sweden. Methods: Ten-and 5-year follow-ups were performed in 2005 to 2007 for 278/327 patients after resective epilepsy surgery from 1995 to 1997 and 2000 to 2002, respectively. All patients had been prospectively followed in the Swedish National Epilepsy Surgery Register. Ninety-three patients, who were presurgically evaluated but not operated, served as controls. Results: In the long term (mean 7.6 years), 62% of operated adults and 50% of operated children were seizure-free, compared to 14% of nonoperated adults (p < 0.001) and 38% of nonoperated children (not significant). Forty-one percent of operated adults and 44% of operated children had sustained seizure freedom since surgery, compared to none of the controls (p < 0.0005). Multivariate analysis identified >= 30 seizures/month at baseline and long epilepsy duration as negative predictors and positive MRI to be a positive predictor of long-term seizure-free outcome. Ten years after surgery, 86% of seizure-free children and 43% of seizure-free adults had stopped AEDs in the surgery groups compared to none of the controls (p < 0.0005). Conclusions: This population-based, prospective study shows good long-term seizure outcomes after resective epilepsy surgery. The majority of the patients who are seizure-free after 5 and 10 years have sustained seizure freedom since surgery. Many patients who gain seizure freedom can successfully discontinue AEDs, more often children than adults. Classification of evidence: This study provides Class III evidence that more patients are seizure-free and have stopped AED treatment in the long term after resective epilepsy surgery than nonoperated epilepsy patients.

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Rydenhag, Bertil (författare)
  • Olsson, Ingrid (författare)
  • Flink, RolandUppsala universitet,Klinisk neurofysiologi(Swepub:uu)rolandfk (författare)
  • Kumlien, EvaUppsala universitet,Neurologi(Swepub:uu)evakumli (författare)
  • Kallen, Kristina (författare)
  • Malmgren, Kristina (författare)
  • Uppsala universitetKlinisk neurofysiologi (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Neurology81:14, s. 1244-12510028-38781526-632X

Internetlänk

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  • Neurology (Sök värdpublikationen i LIBRIS)

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