Search: id:"swepub:oai:DiVA.org:uu-221006" >
Risk of symptomatic...
-
Johansson, K.Karolinska Institutet
(author)
Risk of symptomatic gallstones and cholecystectomy after a very-low-calorie diet or low-calorie diet in a commercial weight loss program : 1-year matched cohort study
- Article/chapterEnglish2014
Publisher, publication year, extent ...
-
2013-05-22
-
Nature Publishing Group,2014
-
printrdacarrier
Numbers
-
LIBRIS-ID:oai:DiVA.org:uu-221006
-
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-221006URI
-
https://doi.org/10.1038/ijo.2013.83DOI
-
https://urn.kb.se/resolve?urn=urn:nbn:se:gih:diva-4741URI
-
http://kipublications.ki.se/Default.aspx?queryparsed=id:128347418URI
Supplementary language notes
-
Language:English
-
Summary in:English
Part of subdatabase
Classification
-
Subject category:ref swepub-contenttype
-
Subject category:art swepub-publicationtype
Notes
-
BACKGROUND: Concern exists regarding gallstones as an adverse event of very-low-calorie diets (VLCDs; <800 kcal per day). OBJECTIVE: To assess the risk of symptomatic gallstones requiring hospital care and/or cholecystectomy in a commercial weight loss program using VLCD or low-calorie diet (LCD). DESIGN: A 1-year matched cohort study of consecutively enrolled adults in a commercial weight loss program conducted at 28 Swedish centers between 2006 and 2009. A 3-month weight loss phase of VLCD (500 kcal per day) or LCD (1200-1500 kcal per day) was followed by a 9-month weight maintenance phase. Matching (1: 1) was performed by age, sex, body mass index, waist circumference and gallstone history (n = 3320: 3320). Gallstone and cholecystectomy data were retrieved from the Swedish National Patient Register. RESULTS: One-year weight loss was greater in the VLCD than in the LCD group (-11.1 versus -8.1 kg; adjusted difference, -2.8 kg, 95% CI -3.1 to -2.4; P<0.001). During 6361 person-years, 48 and 14 gallstones requiring hospital care occurred in the VLCD and LCD groups, respectively, (152 versus 44/10 000 person-years; hazard ratio, 3.4, 95% CI 1.8-6.3; P<0.001; number-needed-to-harm, 92, 95% CI 63-168; P<0.001). Of the 62 gallstone events, 38 (61%) resulted in cholecystectomy (29 versus 9; hazard ratio, 3.2, 95% CI 1.5-6.8; P = 0.003; number-needed-to-harm, 151, 95% CI 94-377; P<0.001). Adjusting for 3-month weight loss attenuated the hazard ratios, but the risk remained higher with VLCD than LCD for gallstones (2.5, 95% CI 1.3-5.1; P = 0.009) and became borderline for cholecystectomy (2.2, 95% CI 0.9-5.2; P = 0.08). CONCLUSION: The risk of symptomatic gallstones requiring hospitalization or cholecystectomy, albeit low, was 3-fold greater with VLCD than LCD during the 1-year commercial weight loss program.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Sundström, J.Uppsala universitet,Institutionen för medicinska vetenskaper(Swepub:uu)johasund
(author)
-
Marcus, C.Karolinska Institutet
(author)
-
Hemmingsson, ErikKarolinska institutet(Swepub:gih)erik.hemmingsson
(author)
-
Neovius, M.Karolinska Institutet
(author)
-
Karolinska InstitutetInstitutionen för medicinska vetenskaper
(creator_code:org_t)
Related titles
-
In:International Journal of Obesity: Nature Publishing Group38:2, s. 279-2840307-05651476-5497
Internet link
Find in a library
To the university's database