Search: (WFRF:(Heath Andrew C.)) srt2:(2010-2014) srt2:(2010) pers:(Wareham Nicholas J) pers:(Salomaa Veikko) >
Thirty new loci for...
Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies
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Elks, Cathy E (author)
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Perry, John R B (author)
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Sulem, Patrick (author)
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show more...
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Chasman, Daniel I (author)
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Franceschini, Nora (author)
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He, Chunyan (author)
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Lunetta, Kathryn L (author)
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Visser, Jenny A (author)
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Byrne, Enda M (author)
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Cousminer, Diana L (author)
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Gudbjartsson, Daniel F (author)
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Esko, Tõnu (author)
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Feenstra, Bjarke (author)
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Hottenga, Jouke-Jan (author)
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Koller, Daniel L (author)
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Kutalik, Zoltán (author)
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Lin, Peng (author)
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Mangino, Massimo (author)
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Marongiu, Mara (author)
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McArdle, Patrick F (author)
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Smith, Albert V (author)
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Stolk, Lisette (author)
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van Wingerden, Sophie H (author)
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Zhao, Jing Hua (author)
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Albrecht, Eva (author)
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Corre, Tanguy (author)
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- Ingelsson, Erik, 1975- (author)
- Karolinska Institutet
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Hayward, Caroline (author)
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- Magnusson, Patrik K E (author)
- Karolinska Institutet
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Smith, Erin N (author)
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Ulivi, Shelia (author)
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Warrington, Nicole M (author)
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Zgaga, Lina (author)
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Alavere, Helen (author)
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Amin, Najaf (author)
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Aspelund, Thor (author)
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Bandinelli, Stefania (author)
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Barroso, Inês (author)
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Berenson, Gerald S (author)
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Bergmann, Sven (author)
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Blackburn, Hannah (author)
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Boerwinkle, Eric (author)
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Buring, Julie E (author)
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Busonero, Fabio (author)
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Campbell, Harry (author)
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Chanock, Stephen J (author)
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Chen, Wei (author)
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Cornelis, Marilyn C (author)
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Couper, David (author)
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Coviello, Andrea D (author)
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d'Adamo, Pio (author)
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- de Faire, Ulf (author)
- Karolinska Institutet
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de Geus, Eco J C (author)
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Deloukas, Panos (author)
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Döring, Angela (author)
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Smith, George Davey (author)
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Easton, Douglas F (author)
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Eiriksdottir, Gudny (author)
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Emilsson, Valur (author)
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Eriksson, Johan (author)
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Ferrucci, Luigi (author)
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Folsom, Aaron R (author)
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Foroud, Tatiana (author)
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Garcia, Melissa (author)
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Gasparini, Paolo (author)
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Geller, Frank (author)
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Gieger, Christian (author)
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Gudnason, Vilmundur (author)
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- Hall, Per (author)
- Karolinska Institutet
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Hankinson, Susan E (author)
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Ferreli, Liana (author)
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Heath, Andrew C (author)
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Hernandez, Dena G (author)
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Hofman, Albert (author)
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Hu, Frank B (author)
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Illig, Thomas (author)
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Järvelin, Marjo-Riitta (author)
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Johnson, Andrew D (author)
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Karasik, David (author)
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Khaw, Kay-Tee (author)
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Kiel, Douglas P (author)
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Kilpeläinen, Tuomas O (author)
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Kolcic, Ivana (author)
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Kraft, Peter (author)
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Launer, Lenore J (author)
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Laven, Joop S E (author)
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Li, Shengxu (author)
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Liu, Jianjun (author)
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Levy, Daniel (author)
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Martin, Nicholas G (author)
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McArdle, Wendy L (author)
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Melbye, Mads (author)
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Mooser, Vincent (author)
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Murray, Jeffrey C (author)
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Murray, Sarah S (author)
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Nalls, Michael A (author)
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Navarro, Pau (author)
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Nelis, Mari (author)
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Ness, Andrew R (author)
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Northstone, Kate (author)
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Oostra, Ben A (author)
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Peacock, Munro (author)
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Palmer, Lyle J (author)
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Palotie, Aarno (author)
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Paré, Guillaume (author)
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Parker, Alex N (author)
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- Pedersen, Nancy L (author)
- Karolinska Institutet
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Peltonen, Leena (author)
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Pennell, Craig E (author)
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Pharoah, Paul (author)
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Polasek, Ozren (author)
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Plump, Andrew S (author)
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Pouta, Anneli (author)
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Porcu, Eleonora (author)
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Rafnar, Thorunn (author)
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Rice, John P (author)
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Ring, Susan M (author)
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Rivadeneira, Fernando (author)
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Rudan, Igor (author)
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Sala, Cinzia (author)
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Salomaa, Veikko (author)
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Sanna, Serena (author)
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Schlessinger, David (author)
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Schork, Nicholas J (author)
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Scuteri, Angelo (author)
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Segrè, Ayellet V (author)
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Shuldiner, Alan R (author)
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Soranzo, Nicole (author)
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Sovio, Ulla (author)
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Srinivasan, Sathanur R (author)
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Strachan, David P (author)
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Tammesoo, Mar-Liis (author)
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Tikkanen, Emmi (author)
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Toniolo, Daniela (author)
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Tsui, Kim (author)
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Tryggvadottir, Laufey (author)
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Tyrer, Jonathon (author)
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Uda, Manuela (author)
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van Dam, Rob M (author)
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van Meurs, Joyce B J (author)
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Vollenweider, Peter (author)
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Waeber, Gerard (author)
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Wareham, Nicholas J (author)
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Waterworth, Dawn M (author)
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Weedon, Michael N (author)
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Wichmann, H Erich (author)
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Willemsen, Gonneke (author)
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Wilson, James F (author)
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Wright, Alan F (author)
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Young, Lauren (author)
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Zhai, Guangju (author)
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Zhuang, Wei Vivian (author)
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Bierut, Laura J (author)
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Boomsma, Dorret I (author)
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Boyd, Heather A (author)
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Crisponi, Laura (author)
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Demerath, Ellen W (author)
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van Duijn, Cornelia M (author)
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Econs, Michael J (author)
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Harris, Tamara B (author)
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Hunter, David J (author)
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Loos, Ruth J F (author)
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Metspalu, Andres (author)
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Montgomery, Grant W (author)
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Ridker, Paul M (author)
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Spector, Tim D (author)
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Streeten, Elizabeth A (author)
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Stefansson, Kari (author)
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Thorsteinsdottir, Unnur (author)
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Uitterlinden, André G (author)
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Widen, Elisabeth (author)
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Murabito, Joanne M (author)
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Ong, Ken K (author)
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Murray, Anna (author)
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(creator_code:org_t)
- 2010-11-21
- 2010
- English.
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In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 42:12, s. 1077-85
- Related links:
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https://europepmc.or...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
Close
- To identify loci for age at menarche, we performed a meta-analysis of 32 genome-wide association studies in 87,802 women of European descent, with replication in up to 14,731 women. In addition to the known loci at LIN28B (P = 5.4 × 10⁻⁶⁰) and 9q31.2 (P = 2.2 × 10⁻³³), we identified 30 new menarche loci (all P < 5 × 10⁻⁸) and found suggestive evidence for a further 10 loci (P < 1.9 × 10⁻⁶). The new loci included four previously associated with body mass index (in or near FTO, SEC16B, TRA2B and TMEM18), three in or near other genes implicated in energy homeostasis (BSX, CRTC1 and MCHR2) and three in or near genes implicated in hormonal regulation (INHBA, PCSK2 and RXRG). Ingenuity and gene-set enrichment pathway analyses identified coenzyme A and fatty acid biosynthesis as biological processes related to menarche timing.
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- By the author/editor
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Elks, Cathy E
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Perry, John R B
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Sulem, Patrick
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Chasman, Daniel ...
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Franceschini, No ...
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He, Chunyan
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show more...
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Lunetta, Kathryn ...
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Visser, Jenny A
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Byrne, Enda M
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Cousminer, Diana ...
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Gudbjartsson, Da ...
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Esko, Tõnu
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Feenstra, Bjarke
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Hottenga, Jouke- ...
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Koller, Daniel L
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Kutalik, Zoltán
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Lin, Peng
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Mangino, Massimo
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Marongiu, Mara
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McArdle, Patrick ...
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Smith, Albert V
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Stolk, Lisette
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van Wingerden, S ...
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Zhao, Jing Hua
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Albrecht, Eva
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Corre, Tanguy
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Ingelsson, Erik, ...
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Hayward, Carolin ...
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Magnusson, Patri ...
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Smith, Erin N
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Ulivi, Shelia
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Warrington, Nico ...
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Zgaga, Lina
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Alavere, Helen
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Amin, Najaf
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Aspelund, Thor
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Bandinelli, Stef ...
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Barroso, Inês
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Berenson, Gerald ...
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Bergmann, Sven
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Blackburn, Hanna ...
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Boerwinkle, Eric
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Buring, Julie E
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Busonero, Fabio
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Campbell, Harry
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Chanock, Stephen ...
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Chen, Wei
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Cornelis, Marily ...
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Couper, David
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Coviello, Andrea ...
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d'Adamo, Pio
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de Faire, Ulf
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de Geus, Eco J C
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Deloukas, Panos
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Döring, Angela
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Smith, George Da ...
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Easton, Douglas ...
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Eiriksdottir, Gu ...
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Emilsson, Valur
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Eriksson, Johan
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Ferrucci, Luigi
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Folsom, Aaron R
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Foroud, Tatiana
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Garcia, Melissa
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Gasparini, Paolo
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Geller, Frank
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Gieger, Christia ...
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Gudnason, Vilmun ...
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Hall, Per
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Hankinson, Susan ...
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Ferreli, Liana
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Heath, Andrew C
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Hernandez, Dena ...
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Hofman, Albert
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Hu, Frank B
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Illig, Thomas
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Järvelin, Marjo- ...
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Johnson, Andrew ...
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Karasik, David
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Khaw, Kay-Tee
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Kiel, Douglas P
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Kilpeläinen, Tuo ...
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Kolcic, Ivana
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Kraft, Peter
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Launer, Lenore J
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Laven, Joop S E
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Li, Shengxu
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Liu, Jianjun
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Levy, Daniel
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Martin, Nicholas ...
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McArdle, Wendy L
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Melbye, Mads
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Mooser, Vincent
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Murray, Jeffrey ...
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Murray, Sarah S
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Nalls, Michael A
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Navarro, Pau
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Nelis, Mari
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Ness, Andrew R
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Northstone, Kate
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Oostra, Ben A
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Peacock, Munro
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Palmer, Lyle J
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Palotie, Aarno
-
Paré, Guillaume
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Parker, Alex N
-
Pedersen, Nancy ...
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Peltonen, Leena
-
Pennell, Craig E
-
Pharoah, Paul
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Polasek, Ozren
-
Plump, Andrew S
-
Pouta, Anneli
-
Porcu, Eleonora
-
Rafnar, Thorunn
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Rice, John P
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Ring, Susan M
-
Rivadeneira, Fer ...
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Rudan, Igor
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Sala, Cinzia
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Salomaa, Veikko
-
Sanna, Serena
-
Schlessinger, Da ...
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Schork, Nicholas ...
-
Scuteri, Angelo
-
Segrè, Ayellet V
-
Shuldiner, Alan ...
-
Soranzo, Nicole
-
Sovio, Ulla
-
Srinivasan, Sath ...
-
Strachan, David ...
-
Tammesoo, Mar-Li ...
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Tikkanen, Emmi
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Toniolo, Daniela
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Tsui, Kim
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Tryggvadottir, L ...
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Tyrer, Jonathon
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Uda, Manuela
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van Dam, Rob M
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van Meurs, Joyce ...
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Vollenweider, Pe ...
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Waeber, Gerard
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Wareham, Nichola ...
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Waterworth, Dawn ...
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Weedon, Michael ...
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Wichmann, H Eric ...
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Willemsen, Gonne ...
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Wilson, James F
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Wright, Alan F
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Young, Lauren
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Zhai, Guangju
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Zhuang, Wei Vivi ...
-
Bierut, Laura J
-
Boomsma, Dorret ...
-
Boyd, Heather A
-
Crisponi, Laura
-
Demerath, Ellen ...
-
van Duijn, Corne ...
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Econs, Michael J
-
Harris, Tamara B
-
Hunter, David J
-
Loos, Ruth J F
-
Metspalu, Andres
-
Montgomery, Gran ...
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Ridker, Paul M
-
Spector, Tim D
-
Streeten, Elizab ...
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Stefansson, Kari
-
Thorsteinsdottir ...
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Uitterlinden, An ...
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Widen, Elisabeth
-
Murabito, Joanne ...
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Ong, Ken K
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Murray, Anna
-
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- Articles in the publication
-
Nature Genetics
- By the university
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Uppsala University
-
Karolinska Institutet