No interactions between previously associated 2-hour glucose gene variants and physical activity or BMI on 2-hour glucose levels

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Scott, Robert A (author)

No interactions between previously associated 2-hour glucose gene variants and physical activity or BMI on 2-hour glucose levels

Article/chapterEnglish2012

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2012-04-13
Alexandria, VA :American Diabetes Association,2012
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LIBRIS-ID:oai:DiVA.org:uu-223046
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-223046URI
https://doi.org/10.2337/db11-0973DOI
https://lup.lub.lu.se/record/2563092URI
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-53506URI
http://kipublications.ki.se/Default.aspx?queryparsed=id:124482552URI

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Language:English
Summary in:English

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SwePubSwePub

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

Gene-lifestyle interactions have been suggested to contribute to the development of type 2 diabetes. Glucose levels 2 h after a standard 75-g glucose challenge are used to diagnose diabetes and are associated with both genetic and lifestyle factors. However, whether these factors interact to determine 2-h glucose levels is unknown. We meta-analyzed single nucleotide polymorphism (SNP) × BMI and SNP × physical activity (PA) interaction regression models for five SNPs previously associated with 2-h glucose levels from up to 22 studies comprising 54,884 individuals without diabetes. PA levels were dichotomized, with individuals below the first quintile classified as inactive (20%) and the remainder as active (80%). BMI was considered a continuous trait. Inactive individuals had higher 2-h glucose levels than active individuals (β = 0.22 mmol/L [95% CI 0.13-0.31], P = 1.63 × 10(-6)). All SNPs were associated with 2-h glucose (β = 0.06-0.12 mmol/allele, P ≤ 1.53 × 10(-7)), but no significant interactions were found with PA (P > 0.18) or BMI (P ≥ 0.04). In this large study of gene-lifestyle interaction, we observed no interactions between genetic and lifestyle factors, both of which were associated with 2-h glucose. It is perhaps unlikely that top loci from genome-wide association studies will exhibit strong subgroup-specific effects, and may not, therefore, make the best candidates for the study of interactions.

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Chu, Audrey Y (author)
Grarup, Niels (author)
Manning, Alisa K (author)
Hivert, Marie-France (author)
Shungin, DmitryUmeå universitet,Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genetisk och molekylär epidemiologi,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Genetic and Molecular Epidemiology,Institutionen för odontologi,Medicin(Swepub:umu)dmsh0003 (author)
Tönjes, Anke (author)
Yesupriya, Ajay (author)
Barnes, Daniel (author)
Bouatia-Naji, Nabila (author)
Glazer, Nicole L (author)
Jackson, Anne U (author)
Kutalik, Zoltán (author)
Lagou, Vasiliki (author)
Marek, Diana (author)
Rasmussen-Torvik, Laura J (author)
Stringham, Heather M (author)
Tanaka, Toshiko (author)
Aadahl, Mette (author)
Arking, Dan E (author)
Bergmann, Sven (author)
Boerwinkle, Eric (author)
Bonnycastle, Lori L (author)
Bornstein, Stefan R (author)
Brunner, Eric (author)
Bumpstead, Suzannah J (author)
Brage, Soren (author)
Carlson, Olga D (author)
Chen, Han (author)
Chen, Yii-Der Ida (author)
Chines, Peter S (author)
Collins, Francis S (author)
Couper, David J (author)
Dennison, Elaine M (author)
Dowling, Nicole F (author)
Egan, Josephine S (author)
Ekelund, Ulf (author)
Erdos, Michael R (author)
Forouhi, Nita G (author)
Fox, Caroline S (author)
Goodarzi, Mark O (author)
Grässler, Jürgen (author)
Gustafsson, Stefan (author)
Hallmans, GöranUmeå universitet,Näringsforskning(Swepub:umu)goha0001 (author)
Hansen, Torben (author)
Hingorani, Aroon (author)
Holloway, John W (author)
Hu, Frank B (author)
Isomaa, Bo (author)
Jameson, Karen A (author)
Johansson, IngegerdUmeå universitet,Kariologi(Swepub:umu)injo0003 (author)
Jonsson, AnnaLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)med-jsa (author)
Jørgensen, Torben (author)
Kivimaki, Mika (author)
Kovacs, Peter (author)
Kumari, Meena (author)
Kuusisto, Johanna (author)
Laakso, Markku (author)
Lecoeur, Cécile (author)
Lévy-Marchal, Claire (author)
Li, Guo (author)
Loos, Ruth J F (author)
Lyssenko, ValeriyaLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)endo-vly (author)
Marmot, Michael (author)
Marques-Vidal, Pedro (author)
Morken, Mario A (author)
Müller, Gabriele (author)
North, Kari E (author)
Pankow, James S (author)
Payne, Felicity (author)
Prokopenko, Inga (author)
Psaty, Bruce M (author)
Renström, FridaLund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups(Swepub:lu)med-frm (author)
Rice, Ken (author)
Rotter, Jerome I (author)
Rybin, Denis (author)
Sandholt, Camilla H (author)
Sayer, Avan A (author)
Shrader, Peter (author)
Schwarz, Peter E H (author)
Siscovick, David S (author)
Stancáková, Alena (author)
Stumvoll, Michael (author)
Teslovich, Tanya M (author)
Waeber, Gérard (author)
Williams, Gordon H (author)
Witte, Daniel R (author)
Wood, Andrew R (author)
Xie, Weijia (author)
Boehnke, Michael (author)
Cooper, Cyrus (author)
Ferrucci, Luigi (author)
Froguel, Philippe (author)
Groop, LeifLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)endo-lgr (author)
Kao, W H Linda (author)
Vollenweider, Peter (author)
Walker, Mark (author)
Watanabe, Richard M (author)
Pedersen, Oluf (author)
Meigs, James B (author)
Ingelsson, Erik,1975-Karolinska Institutet(Swepub:uu)ering425 (author)
Barroso, Inês (author)
Florez, Jose C (author)
Franks, PaulLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genetisk och molekylär epidemiologi,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Genetic and Molecular Epidemiology(Swepub:lu)med-plf (author)
Dupuis, Josée (author)
Wareham, Nicholas J (author)
Langenberg, Claudia (author)
Genomik, diabetes och endokrinologiForskargrupper vid Lunds universitet (creator_code:org_t)

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In:DiabetesAlexandria, VA : American Diabetes Association61:5, s. 1291-12960012-17971939-327X

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By the author/editor: Scott, Robert A; Chu, Audrey Y; Grarup, Niels; Manning, Alisa K; Hivert, Marie-Fr ...; Shungin, Dmitry; show more...; Tönjes, Anke; Yesupriya, Ajay; Barnes, Daniel; Bouatia-Naji, Na ...; Glazer, Nicole L; Jackson, Anne U; Kutalik, Zoltán; Lagou, Vasiliki; Marek, Diana; Rasmussen-Torvik ...; Stringham, Heath ...; Tanaka, Toshiko; Aadahl, Mette; Arking, Dan E; Bergmann, Sven; Boerwinkle, Eric; Bonnycastle, Lor ...; Bornstein, Stefa ...; Brunner, Eric; Bumpstead, Suzan ...; Brage, Soren; Carlson, Olga D; Chen, Han; Chen, Yii-Der Id ...; Chines, Peter S; Collins, Francis ...; Couper, David J; Dennison, Elaine ...; Dowling, Nicole ...; Egan, Josephine ...; Ekelund, Ulf; Erdos, Michael R; Forouhi, Nita G; Fox, Caroline S; Goodarzi, Mark O; Grässler, Jürgen; Gustafsson, Stef ...; Hallmans, Göran; Hansen, Torben; Hingorani, Aroon; Holloway, John W; Hu, Frank B; Isomaa, Bo; Jameson, Karen A; Johansson, Ingeg ...; Jonsson, Anna; Jørgensen, Torbe ...; Kivimaki, Mika; Kovacs, Peter; Kumari, Meena; Kuusisto, Johann ...; Laakso, Markku; Lecoeur, Cécile; Lévy-Marchal, Cl ...; Li, Guo; Loos, Ruth J F; Lyssenko, Valeri ...; Marmot, Michael; Marques-Vidal, P ...; Morken, Mario A; Müller, Gabriele; North, Kari E; Pankow, James S; Payne, Felicity; Prokopenko, Inga; Psaty, Bruce M; Renström, Frida; Rice, Ken; Rotter, Jerome I; Rybin, Denis; Sandholt, Camill ...; Sayer, Avan A; Shrader, Peter; Schwarz, Peter E ...; Siscovick, David ...; Stancáková, Alen ...; Stumvoll, Michae ...; Teslovich, Tanya ...; Waeber, Gérard; Williams, Gordon ...; Witte, Daniel R; Wood, Andrew R; Xie, Weijia; Boehnke, Michael; Cooper, Cyrus; Ferrucci, Luigi; Froguel, Philipp ...; Groop, Leif; Kao, W H Linda; Vollenweider, Pe ...; Walker, Mark; Watanabe, Richar ...; Pedersen, Oluf; Meigs, James B; Ingelsson, Erik, ...; Barroso, Inês; Florez, Jose C; Franks, Paul; Dupuis, Josée; Wareham, Nichola ...; Langenberg, Clau ...; show less...

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