SwePub
Sök i LIBRIS databas

  Utökad sökning

L773:0090 3493 OR L773:1530 0293
 

Sökning: L773:0090 3493 OR L773:1530 0293 > Early inflammation ...

  • Borges, João BatistaUppsala universitet,Anestesiologi och intensivvård,Hedenstiernalaboratoriet (författare)

Early inflammation mainly affects normally and poorly aerated lung in experimental ventilator-induced lung injury

  • Artikel/kapitelEngelska2014

Förlag, utgivningsår, omfång ...

  • 2014
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:uu-223348
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-223348URI
  • https://doi.org/10.1097/CCM.0000000000000161DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • OBJECTIVE: The common denominator in most forms of ventilator-induced lung injury is an intense inflammatory response mediated by neutrophils. PET with [F]fluoro-2-deoxy-D-glucose can be used to image cellular metabolism, which, during lung inflammatory processes, mainly reflects neutrophil activity, allowing the study of regional lung inflammation in vivo. The aim of this study was to assess the location and magnitude of lung inflammation using PET imaging of [F]fluoro-2-deoxy-D-glucose in a porcine experimental model of early acute respiratory distress syndrome.DESIGN: Prospective laboratory investigation.SETTING: A university animal research laboratory.SUBJECTS: Seven piglets submitted to experimental ventilator-induced lung injury and five healthy controls.INTERVENTIONS: Lung injury was induced by lung lavages and 210 minutes of injurious mechanical ventilation using low positive end-expiratory pressure and high inspiratory pressures. All animals were subsequently studied with dynamic PET imaging of [F]fluoro-2-deoxy-D-glucose. CT scans were acquired at end expiration and end inspiration.MEASUREMENTS AND MAIN RESULTS: [F]fluoro-2-deoxy-D-glucose uptake rate was computed for the whole lung, four isogravitational regions, and regions grouping voxels with similar density. Global and intermediate gravitational zones [F]fluoro-2-deoxy-D-glucose uptakes were higher in ventilator-induced lung injury piglets compared with controls animals. Uptake of normally and poorly aerated regions was also higher in ventilator-induced lung injury piglets compared with control piglets, whereas regions suffering tidal recruitment or tidal hyperinflation had [F]fluoro-2-deoxy-D-glucose uptakes similar to controls.CONCLUSIONS: The present findings suggest that normally and poorly aerated regions-corresponding to intermediate gravitational zones-are the primary targets of the inflammatory process accompanying early experimental ventilator-induced lung injury. This may be attributed to the small volume of the aerated lung, which receives most of ventilation.

Ämnesord och genrebeteckningar

  • Clinical Physiology
  • Klinisk fysiologi

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Costa, Eduardo L V (författare)
  • Suarez-Sipmann, FernandoUppsala universitet,Anestesiologi och intensivvård,Hedenstiernalaboratoriet(Swepub:uu)fersi946 (författare)
  • Widström, CharlesUppsala universitet,Avdelningen för sjukhusfysik (författare)
  • Larsson, AndersUppsala universitet,Anestesiologi och intensivvård,Hedenstiernalaboratoriet(Swepub:uu)andla606 (författare)
  • Amato, Marcelo (författare)
  • Hedenstierna, GöranUppsala universitet,Klinisk fysiologi,Hedenstiernalaboratoriet(Swepub:uu)goranhed (författare)
  • Uppsala universitetAnestesiologi och intensivvård (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Critical Care Medicine42:4, s. e279-e2870090-34931530-0293

Internetlänk

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy