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  • Ameur, AdamUppsala universitet,Institutionen för immunologi, genetik och patologi,Science for Life Laboratory, SciLifeLab (author)

Comprehensive profiling of the vaginal microbiome in HIV positive women using massive parallel semiconductor sequencing

  • Article/chapterEnglish2014

Publisher, publication year, extent ...

  • 2014-03-18
  • Springer Science and Business Media LLC,2014
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-223522
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-223522URI
  • https://doi.org/10.1038/srep04398DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Infections by HIV increase the risk of acquiring secondary viral and bacterial infections and methods are needed to determine the spectrum of co-infections for proper treatment. We used rolling circle amplification (RCA) and Ion Proton sequencing to investigate the vaginal microbiome of 20 HIV positive women from South Africa. A total of 46 different human papillomavirus (HPV) types were found, many of which are not detected by existing genotyping assays. Moreover, the complete genomes of two novel HPV types were determined. Abundance of HPV infections was highly correlated with real-time PCR estimates, indicating that the RCA-Proton method can be used for quantification of individual pathogens. We also identified a large number of other viral, bacterial and parasitic co-infections and the spectrum of these co-infections varied widely between individuals. Our method provides rapid detection of a broad range of pathogens and the ability to reconstruct complete genomes of novel infectious agents.

Added entries (persons, corporate bodies, meetings, titles ...)

  • Meiring, Tracy L. (author)
  • Bunikis, IgnasUppsala universitet,Institutionen för immunologi, genetik och patologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)ignbu776 (author)
  • Häggqvist, SusanaUppsala universitet,Institutionen för immunologi, genetik och patologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)susha415 (author)
  • Lindau, CeciliaUppsala universitet,Science for Life Laboratory, SciLifeLab,Institutionen för immunologi, genetik och patologi(Swepub:uu)cecli863 (author)
  • Lindberg, Julia HedlundUppsala universitet,Institutionen för immunologi, genetik och patologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)julin226 (author)
  • Gustavsson, IngerUppsala universitet,Institutionen för immunologi, genetik och patologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)ingergus (author)
  • Mbulawa, Zizipho Z. A. (author)
  • Williamson, Anna-Lise (author)
  • Gyllensten, UlfUppsala universitet,Institutionen för immunologi, genetik och patologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)ulfgyll (author)
  • Uppsala universitetInstitutionen för immunologi, genetik och patologi (creator_code:org_t)

Related titles

  • In:Scientific Reports: Springer Science and Business Media LLC4, s. 4398-2045-2322

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