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NRP1 Presented in t...
NRP1 Presented in trans to the Endothelium Arrests VEGFR2 Endocytosis, Preventing Angiogenic Signaling and Tumor Initiation
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- Koch, Sina (author)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi,Science for Life Laboratory, SciLifeLab
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- van Meeteren, Laurens A. (author)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi,Science for Life Laboratory, SciLifeLab
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- Morin, Eric (author)
- Uppsala universitet,Cancer och vaskulärbiologi,Science for Life Laboratory, SciLifeLab
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- Testini, Chiara (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Cancer och vaskulärbiologi
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- Weström, Simone (author)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi,Science for Life Laboratory, SciLifeLab
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Björkelund, Hanna (author)
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- Le Jan, Sebastien (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Institutionen för immunologi, genetik och patologi
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- Adler, Jeremy (author)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi,Science for Life Laboratory, SciLifeLab
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Berger, Philipp (author)
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- Claesson-Welsh, Lena (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Cancer och vaskulärbiologi
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(creator_code:org_t)
- Elsevier BV, 2014
- 2014
- English.
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In: Developmental Cell. - : Elsevier BV. - 1534-5807 .- 1878-1551. ; 28:6, s. 633-646
- Related links:
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http://www.cell.com/...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Neuropilin 1 (NRP1) modulates angiogenesis by binding vascular endothelial growth factor (VEGF) and its receptor, VEGFR2. We examined the consequences when VEGFR2 and NRP1 were expressed on the same cell (cis) or on different cells (trans). In cis, VEGF induced rapid VEGFR2/NRP1 complex formation and internalization. In trans, complex formation was delayed and phosphorylation of phospholipase C gamma (PLC gamma) and extracellular regulated kinase 2 (ERK2) was prolonged, whereas ERK1 phosphorylation was reduced. Trans complex formation suppressed initiation and vascularization of NRP1-expressing mouse fibrosarcoma and melanoma. Suppression in trans required high-affinity, steady-state binding of VEGF to NRP1, which was dependent on the NRP1 C-terminal domain. Compatible with a trans effect of NRP1, quiescent vasculature in the developing retina showed continuous high NRP1 expression, whereas angiogenic sprouting occurred where NRP1 levels fluctuated between adjacent endothelial cells. Therefore, through communication in trans, NRP1 can modulate VEGFR2 signaling and suppress angiogenesis.
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- By the author/editor
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Koch, Sina
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van Meeteren, La ...
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Morin, Eric
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Testini, Chiara
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Weström, Simone
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Björkelund, Hann ...
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show more...
-
Le Jan, Sebastie ...
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Adler, Jeremy
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Berger, Philipp
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Claesson-Welsh, ...
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show less...
- Articles in the publication
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Developmental Ce ...
- By the university
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Uppsala University