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Sökning: WFRF:(Drevon Christian A.) > Individual differen...

Individual differences in brain aging : heterogeneity in cortico-hippocampal but not caudate atrophy rates

Nyberg, Lars, 1966- (författare)
Umeå universitet,Institutionen för integrativ medicinsk biologi (IMB),Umeå centrum för funktionell hjärnavbildning (UFBI),Diagnostisk radiologi,Center for Lifespan Changes in Brain and Cognition, University of Oslo, Department of Psychology, University of Oslo, Oslo, Norway
Andersson, Micael (författare)
Umeå universitet,Institutionen för integrativ medicinsk biologi (IMB),Umeå centrum för funktionell hjärnavbildning (UFBI)
Lundquist, Anders, 1978- (författare)
Umeå universitet,Umeå centrum för funktionell hjärnavbildning (UFBI),Statistik
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Baaré, William F.C. (författare)
Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital - Amager and Hvidovre, Copenhagen, Denmark
Bartrés-Faz, David (författare)
Department of Medicine, Faculty of Medicine and Health Sciences, Institut de Neurociències, Universitat de Barcelona, and Institut d’Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Barcelona, Spain
Bertram, Lars (författare)
Center for Lifespan Changes in Brain and Cognition, University of Oslo, Department of Psychology, University of Oslo, Oslo, Norway; Lübeck Interdisciplinary Platform for Genome Analytics (LIGA), University of Lübeck, Lübeck, Germany
Boraxbekk, Carl-Johan, 1980- (författare)
Umeå universitet,Umeå centrum för funktionell hjärnavbildning (UFBI),Diagnostisk radiologi,Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital - Amager and Hvidovre, Copenhagen, Denmark; Faculty of Medical and Health Sciences, Institute for Clinical Medicine, University of Copenhagen, Copenhagen, Denmark; Department of Neurology, Institute of Sports Medicine Copenhagen (ISMC), Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark
Brandmaier, Andreas M. (författare)
Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany; MSB Medical School Berlin, Berlin, Germany; Max Planck UCL Centre for Computational Psychiatry and Ageing Research, Berlin, Germany, and London, UK
Demnitz, Naiara (författare)
Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital - Amager and Hvidovre, Copenhagen, Denmark
Drevon, Christian A. (författare)
Vitas AS, Science Park, Oslo, Norway; Department of Nutrition, Faculty of Medicine, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway
Duezel, Sandra (författare)
Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany
Ebmeier, Klaus P. (författare)
Department of Psychiatry, University of Oxford, Oxford, UK
Ghisletta, Paolo (författare)
Faculty of Psychology and Educational Sciences, University of Geneva, Geneva, Switzerland; UniDistance Suisse, Brig, Switzerland; Swiss National Centre of Competence in Research LIVES, University of Geneva, Geneva, Switzerland
Henson, Richard (författare)
Medical Research Council Cognition and Brain Sciences Unit, Department of Psychiatry, University of Cambridge, Cambridge, England
Jensen, Daria E.A. (författare)
5Department of Psychiatry, University of Oxford, Oxford, UK; Wellcome Centre for Integrative Neuroimaging, Oxford Centre for Human Brain Activity, University of Oxford, Oxford, UK
Kievit, Rogier A. (författare)
Cognitive Neuroscience Department, Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, Nijmegen, The Netherlands
Knights, Ethan (författare)
Medical Research Council Cognition and Brain Sciences Unit, Department of Psychiatry, University of Cambridge, Cambridge, England
Kühn, Simone (författare)
Max Planck UCL Centre for Computational Psychiatry and Ageing Research, Berlin, Germany, and London, UK
Lindenberger, Ulman (författare)
Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany; Max Planck UCL Centre for Computational Psychiatry and Ageing Research, Berlin, Germany, and London, UK
Plachti, Anna (författare)
Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital - Amager and Hvidovre, Copenhagen, Denmark
Pudas, Sara, Docent, 1983- (författare)
Umeå universitet,Institutionen för integrativ medicinsk biologi (IMB),Umeå centrum för funktionell hjärnavbildning (UFBI)
Roe, James M. (författare)
Center for Lifespan Changes in Brain and Cognition, University of Oslo, Department of Psychology, University of Oslo, Oslo, Norway,
Madsen, Kathrine Skak (författare)
Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital - Amager and Hvidovre, Copenhagen, Denmark; Max Planck UCL Centre for Computational Psychiatry and Ageing Research, Berlin, Germany, and London, UK
Solé-Padullés, Cristina (författare)
Department of Medicine, Faculty of Medicine and Health Sciences, Institut de Neurociències, Universitat de Barcelona, and Institut d’Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Barcelona, Spain
Sommerer, Yasmine (författare)
Lübeck Interdisciplinary Platform for Genome Analytics (LIGA), University of Lübeck, Lübeck, Germany
Suri, Sana (författare)
Department of Psychiatry, University of Oxford, Oxford, UK; 1Cognitive Neuroscience Department, Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, Nijmegen, The Netherlands
Zsoldos, Enikő (författare)
Department of Psychiatry, University of Oxford, Oxford, UK; 1Cognitive Neuroscience Department, Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, Nijmegen, The Netherlands
Fjell, Anders M. (författare)
Center for Lifespan Changes in Brain and Cognition, University of Oslo, Department of Psychology, University of Oslo, Oslo, Norway; Center for Computational Radiology and Artificial Intelligence, Oslo University Hospital, Oslo, Norway
Walhovd, Kristine B. (författare)
Center for Lifespan Changes in Brain and Cognition, University of Oslo, Department of Psychology, University of Oslo, Oslo, Norway; Center for Computational Radiology and Artificial Intelligence, Oslo University Hospital, Oslo, Norway
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 (creator_code:org_t)
2022-10-05
2023
Engelska.
Ingår i: Cerebral Cortex. - : Oxford University Press. - 1047-3211 .- 1460-2199. ; 33:9, s. 5075-5081
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • It is well documented that some brain regions, such as association cortices, caudate, and hippocampus, are particularly prone to age-related atrophy, but it has been hypothesized that there are individual differences in atrophy profiles. Here, we document heterogeneity in regional-atrophy patterns using latent-profile analysis of 1,482 longitudinal magnetic resonance imaging observations. The results supported a 2-group solution reflecting differences in atrophy rates in cortical regions and hippocampus along with comparable caudate atrophy. The higher-atrophy group had the most marked atrophy in hippocampus and also lower episodic memory, and their normal caudate atrophy rate was accompanied by larger baseline volumes. Our findings support and refine models of heterogeneity in brain aging and suggest distinct mechanisms of atrophy in striatal versus hippocampal-cortical systems.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Neurosciences (hsv//eng)

Nyckelord

aging
individual differences
caudate
hippocampus
cortex
Medicine
medicin

Publikations- och innehållstyp

ref (ämneskategori)
art (ämneskategori)

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