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The novel steroidal...
The novel steroidal alkaloids dendrogenin A and B promote proliferation of adult neural stem cells
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Khalifa, Shaden A. M. (författare)
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de Medina, Philippe (författare)
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- Erlandsson, Anna (författare)
- Uppsala universitet,Institutionen för folkhälso- och vårdvetenskap
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- El-Seedi, Hesham R. (författare)
- Uppsala universitet,Avdelningen för farmakognosi
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Silvente-Poirot, Sandrine (författare)
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Poirot, Marc (författare)
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(creator_code:org_t)
- Elsevier BV, 2014
- 2014
- Engelska.
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Ingår i: Biochemical and Biophysical Research Communications - BBRC. - : Elsevier BV. - 0006-291X .- 1090-2104. ; 446:3, s. 681-686
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Dendrogenin A (DDA) and dendrogenin B (DDB) are new aminoalkyl oxysterols which display re-differentiation of tumor cells of neuronal origin at nanomolar concentrations. We analyzed the influence of dendrogenins on adult mice neural stem cell proliferation, sphere formation and differentiation. DDA and DDB were found to have potent proliferative effects in neural stem cells. Additionally, they induce neuronal outgrowth from neurospheres during in vitro cultivation. Taken together, our results demonstrate a novel role for dendrogenins A and B in neural stem cell proliferation and differentiation which further increases their likely importance to compensate for neuronal cell loss in the brain. (C) 2014 Elsevier Inc. All rights reserved.
Ämnesord
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Nyckelord
- Neural stem cells
- Neurosteroids
- Oxysterols
- Dendrogenin
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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