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  • Grubb, AndersLund University,Lunds universitet,Avdelningen för klinisk kemi och farmakologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Chemistry and Pharmacology,Department of Laboratory Medicine,Faculty of Medicine (author)

Generation of a new cystatin C-based estimating equation for glomerular filtration rate by use of 7 assays standardized to the international calibrator

  • Article/chapterEnglish2014

Publisher, publication year, extent ...

  • 2014-07-01
  • Oxford University Press (OUP),2014
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-227648
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-227648URI
  • https://doi.org/10.1373/clinchem.2013.220707DOI
  • https://lup.lub.lu.se/record/4455160URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • BACKGROUND:Many different cystatin C-based equations exist for estimating glomerular filtration rate. Major reasons for this are the previous lack of an international cystatin C calibrator and the nonequivalence of results from different cystatin C assays.METHODS:Use of the recently introduced certified reference material, ERM-DA471/IFCC, and further work to achieve high agreement and equivalence of 7 commercially available cystatin C assays allowed a substantial decrease of the CV of the assays, as defined by their performance in an external quality assessment for clinical laboratory investigations. By use of 2 of these assays and a population of 4690 subjects, with large subpopulations of children and Asian and Caucasian adults, with their GFR determined by either renal or plasma inulin clearance or plasma iohexol clearance, we attempted to produce a virtually assay-independent simple cystatin C-based equation for estimation of GFR.RESULTS:We developed a simple cystatin C-based equation for estimation of GFR comprising only 2 variables, cystatin C concentration and age. No terms for race and sex are required for optimal diagnostic performance. The equation, [Formula: see text] is also biologically oriented, with 1 term for the theoretical renal clearance of small molecules and 1 constant for extrarenal clearance of cystatin C.CONCLUSIONS:A virtually assay-independent simple cystatin C-based and biologically oriented equation for estimation of GFR, without terms for sex and race, was produced.

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  • Horio, Masaru (author)
  • Hansson, Lars-OlofUppsala universitet,Biokemisk struktur och funktion (author)
  • Björk, JonasLund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)ymed-jbj (author)
  • Nyman, UlfLund University,Lunds universitet,Diagnostisk radiologi, Malmö,Forskargrupper vid Lunds universitet,Radiology Diagnostics, Malmö,Lund University Research Groups(Swepub:lu)ront-uny (author)
  • Flodin, MatsUppsala universitet,Biokemisk struktur och funktion (author)
  • Larsson, AndersUppsala universitet,Biokemisk struktur och funktion(Swepub:uu)andlarss (author)
  • Bökenkamp, Arend (author)
  • Yasuda, Yoshinari (author)
  • Blufpand, Hester (author)
  • Lindström, VeronicaLund University,Lunds universitet,Avdelningen för klinisk kemi och farmakologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Chemistry and Pharmacology,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)kkem-vli (author)
  • Zegers, Ingrid (author)
  • Althaus, Harald (author)
  • Blirup, SorenLund University,Lunds universitet,Avdelningen för klinisk kemi och farmakologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Chemistry and Pharmacology,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)med-sbr (author)
  • Itoh, Yoshi (author)
  • Sjöström, Per (author)
  • Nordin, Gunnar (author)
  • Christensson, AndersLund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups(Swepub:lu)medf-ach (author)
  • Klima, Horst (author)
  • Sunde, Kathrin (author)
  • Hjort-Christensen, Per (author)
  • Armbruster, David (author)
  • Ferrero, Carlo (author)
  • Avdelningen för klinisk kemi och farmakologiInstitutionen för laboratoriemedicin (creator_code:org_t)

Related titles

  • In:Clinical Chemistry: Oxford University Press (OUP)60:7, s. 974-9860009-91471530-8561

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