Sökning: WFRF:(Andersson Lars A H) >
Efficacy and safety...
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Hijazi, ZiadUppsala universitet,Uppsala kliniska forskningscentrum (UCR),Kardiologi
(författare)
Efficacy and safety of dabigatran compared with warfarin in patients with atrial fibrillation in relation to renal function over time-A RE-LY trial analysis
- Artikel/kapitelEngelska2018
Förlag, utgivningsår, omfång ...
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MOSBY-ELSEVIER,2018
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-352697
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-352697URI
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https://doi.org/10.1016/j.ahj.2017.10.015DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Background: Renal function may decline over time, and the efficacy and safety of dabigatran in atrial fibrillation (AF) in relation to renal function changes are unknown.& para;& para;Methods: The RE-LY trial randomized 18,113 patients with AF to 2 doses of dabigatran or warfarin for stroke prevention. Serial creatinine measurements were available in 16,988 patients. The relations between treatment, outcomes, and renal function (Cockcroft-Gault) were investigated using Cox-regression (1) with renal function as a time-dependent covariate and (2) according to worsening renal function (WRF) during follow-up, predefined as a decline in estimated glomerular filtration rate >20% from baseline.& para;& para;Results: During a median follow-up of 1.8 years, 4,106 (24.2%) participants were observed to have WRF, and 12,882 (75.8%) had stable renal function. The risks of all-cause mortality and major bleeding were higher in patients with WRF versus those with stable renal function (hazard ratio [95% CI]: 2.17 [1.81-2.59] and 1.43 [1.19-1.71]. respectively; both P < .0005). The efficacy and safety of dabigatran versus warfarin were similar irrespective of renal function changes over time (interaction P values >= .13 in both models). Dabigatran 110 mg showed a greater relative risk reduction of major bleeding in patients with normal renal function (estimated glomerular filtration rate >80 mL/min) during follow-up (interaction P= .026).& para;& para;Conclusions: In AF, WRF was associated with a higher risk of death and major bleeding. The efficacy and safety profile of dabigatran compared with warfarin was similar irrespective of renal function changes over time. Dabigatran 110 mg showed a greater relative risk reduction of major bleeding in patients with normal renal function during follow-up.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Hohnloser, Stefan H.Goethe Univ Frankfurt, Dept Cardiol, Frankfurt, Germany
(författare)
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Oldgren, Jonas,1964-Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR)(Swepub:uu)jonaoldg
(författare)
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Andersson, UlrikaUppsala universitet,Uppsala kliniska forskningscentrum (UCR)(Swepub:uu)ulran224
(författare)
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Connolly, Stuart J.Populat Hlth Res Inst, Hamilton, ON, Canada
(författare)
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Eikelboom, John W.Populat Hlth Res Inst, Hamilton, ON, Canada
(författare)
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Ezekowitz, Michael D.Thomas Jefferson Med Coll, Wynnewood, PA USA;Heart Ctr, Wynnewood, PA USA
(författare)
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Reilly, Paul A.Boehringer Ingelheim Pharmaceut, Ridgefield, CT USA
(författare)
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Yusuf, SalimPopulat Hlth Res Inst, Hamilton, ON, Canada
(författare)
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Wallentin, Lars,1943-Uppsala universitet,Uppsala kliniska forskningscentrum (UCR)(Swepub:uu)larswall
(författare)
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Uppsala universitetUppsala kliniska forskningscentrum (UCR)
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:American Heart Journal: MOSBY-ELSEVIER198, s. 169-1770002-87031097-6744
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Hijazi, Ziad
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Hohnloser, Stefa ...
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Oldgren, Jonas, ...
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Andersson, Ulrik ...
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Connolly, Stuart ...
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Eikelboom, John ...
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Ezekowitz, Micha ...
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Reilly, Paul A.
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