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Mosaic loss of chro...
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Forsberg, Lars A.Uppsala universitet,Science for Life Laboratory, SciLifeLab,Medicinsk genetik och genomik
(author)
Mosaic loss of chromosome Y in peripheral blood is associated with shorter survival and higher risk of cancer
- Article/chapterEnglish2014
Publisher, publication year, extent ...
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2014-04-28
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Springer Science and Business Media LLC,2014
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-228467
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-228467URI
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https://doi.org/10.1038/ng.2966DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:129149232URI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Incidence and mortality for sex-unspecific cancers are higher among men, a fact that is largely unexplained(1,2). Furthermore, age-related loss of chromosome Y (LOY) is frequent in normal hematopoietic cells(3,4), but the phenotypic consequences of LOY have been elusive(5-10). From analysis of 1,153 elderly men, we report that LOY in peripheral blood was associated with risks of all-cause mortality (hazards ratio (HR) = 1.91, 95% confidence interval (CI) = 1.17-3.13; 637 events) and non-hematological cancer mortality (HR = 3.62, 95% CI = 1.56-8.41; 132 events). LOY affected at least 8.2% of the subjects in this cohort, and median survival times among men with LOY were 5.5 years shorter. Association of LOY with risk of all-cause mortality was validated in an independent cohort (HR = 3.66) in which 20.5% of subjects showed LOY. These results illustrate the impact of post-zygotic mosaicism on disease risk, could explain why males are more frequently affected by cancer and suggest that chromosome Y is important in processes beyond sex determination. LOY in blood could become a predictive biomarker of male carcinogenesis.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Rasi, ChiaraUppsala universitet,Science for Life Laboratory, SciLifeLab,Medicinsk genetik och genomik(Swepub:uu)chira497
(author)
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Malmqvist, NiklasUppsala universitet,Science for Life Laboratory, SciLifeLab,Institutionen för medicinska vetenskaper,Medicinsk genetik och genomik
(author)
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Davies, HannaUppsala universitet,Science for Life Laboratory, SciLifeLab,Medicinsk genetik och genomik(Swepub:uu)handa349
(author)
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Pasupulati, SaichandUppsala universitet,Science for Life Laboratory, SciLifeLab,Institutionen för immunologi, genetik och patologi
(author)
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Pakalapati, GeetaUppsala universitet,Institutionen för immunologi, genetik och patologi,Science for Life Laboratory, SciLifeLab
(author)
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Sandgren, JohannaKarolinska Institutet
(author)
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de Stahl, Teresita DiazKarolinska Institutet
(author)
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Zaghlool, AmmarUppsala universitet,Science for Life Laboratory, SciLifeLab,Genomik(Swepub:uu)ammza789
(author)
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Giedraitis, VilmantasUppsala universitet,Geriatrik(Swepub:uu)vigie517
(author)
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Lannfelt, LarsUppsala universitet,Geriatrik(Swepub:uu)lalan021
(author)
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Score, Joannah
(author)
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Cross, Nicholas C. P.
(author)
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Absher, Devin
(author)
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Tiensuu Janson, EvaUppsala universitet,Onkologisk endokrinologi(Swepub:uu)evatieja
(author)
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Lindgren, Cecilia M.
(author)
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Morris, Andrew P.
(author)
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Ingelsson, ErikUppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)ering425
(author)
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Lind, LarsUppsala universitet,Kardiovaskulär epidemiologi(Swepub:uu)larslind
(author)
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Dumanski, Jan P.Uppsala universitet,Science for Life Laboratory, SciLifeLab,Medicinsk genetik och genomik(Swepub:uu)janduman
(author)
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Uppsala universitetScience for Life Laboratory, SciLifeLab
(creator_code:org_t)
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In:Nature Genetics: Springer Science and Business Media LLC46:6, s. 624-6281061-40361546-1718
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