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Mosaic loss of chro...
Mosaic loss of chromosome Y in peripheral blood is associated with shorter survival and higher risk of cancer
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- Forsberg, Lars A. (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Medicinsk genetik och genomik
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- Rasi, Chiara (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Medicinsk genetik och genomik
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- Malmqvist, Niklas (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Institutionen för medicinska vetenskaper,Medicinsk genetik och genomik
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- Davies, Hanna (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Medicinsk genetik och genomik
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- Pasupulati, Saichand (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Institutionen för immunologi, genetik och patologi
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- Pakalapati, Geeta (author)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi,Science for Life Laboratory, SciLifeLab
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- Sandgren, Johanna (author)
- Karolinska Institutet
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- de Stahl, Teresita Diaz (author)
- Karolinska Institutet
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- Zaghlool, Ammar (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Genomik
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- Giedraitis, Vilmantas (author)
- Uppsala universitet,Geriatrik
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- Lannfelt, Lars (author)
- Uppsala universitet,Geriatrik
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Score, Joannah (author)
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Cross, Nicholas C. P. (author)
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Absher, Devin (author)
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- Tiensuu Janson, Eva (author)
- Uppsala universitet,Onkologisk endokrinologi
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Lindgren, Cecilia M. (author)
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Morris, Andrew P. (author)
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- Ingelsson, Erik (author)
- Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab
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- Lind, Lars (author)
- Uppsala universitet,Kardiovaskulär epidemiologi
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- Dumanski, Jan P. (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Medicinsk genetik och genomik
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(creator_code:org_t)
- 2014-04-28
- 2014
- English.
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In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 46:6, s. 624-628
- Related links:
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Abstract
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- Incidence and mortality for sex-unspecific cancers are higher among men, a fact that is largely unexplained(1,2). Furthermore, age-related loss of chromosome Y (LOY) is frequent in normal hematopoietic cells(3,4), but the phenotypic consequences of LOY have been elusive(5-10). From analysis of 1,153 elderly men, we report that LOY in peripheral blood was associated with risks of all-cause mortality (hazards ratio (HR) = 1.91, 95% confidence interval (CI) = 1.17-3.13; 637 events) and non-hematological cancer mortality (HR = 3.62, 95% CI = 1.56-8.41; 132 events). LOY affected at least 8.2% of the subjects in this cohort, and median survival times among men with LOY were 5.5 years shorter. Association of LOY with risk of all-cause mortality was validated in an independent cohort (HR = 3.66) in which 20.5% of subjects showed LOY. These results illustrate the impact of post-zygotic mosaicism on disease risk, could explain why males are more frequently affected by cancer and suggest that chromosome Y is important in processes beyond sex determination. LOY in blood could become a predictive biomarker of male carcinogenesis.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
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- ref (subject category)
- art (subject category)
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- By the author/editor
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Forsberg, Lars A ...
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Rasi, Chiara
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Malmqvist, Nikla ...
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Davies, Hanna
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Pasupulati, Saic ...
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Pakalapati, Geet ...
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Sandgren, Johann ...
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de Stahl, Teresi ...
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Zaghlool, Ammar
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Giedraitis, Vilm ...
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Lannfelt, Lars
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Score, Joannah
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Cross, Nicholas ...
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Absher, Devin
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Tiensuu Janson, ...
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Lindgren, Cecili ...
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Morris, Andrew P ...
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Ingelsson, Erik
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Lind, Lars
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Dumanski, Jan P.
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
- Articles in the publication
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Nature Genetics
- By the university
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Uppsala University
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Karolinska Institutet