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Ploidy and clinical...
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Sandahl, Julie Damgaard
(author)
Ploidy and clinical characteristics of childhood acute myeloid leukemia : A NOPHO-AML study
- Article/chapterEnglish2014
Publisher, publication year, extent ...
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2014-04-18
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Wiley,2014
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-228680
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-228680URI
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https://doi.org/10.1002/gcc.22177DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-91181URI
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https://lup.lub.lu.se/record/4609290URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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We report the first large series (n=596) of pediatric acute myeloid leukemia (AML) focusing on modal numbers (MN) from the population-based NOPHO-AML trials. Abnormal karyotypes were present in 452 cases (76%) and numerical aberrations were present in 40% (n=237) of all pediatric AML. Among patients with an abnormal karyotype, the MN 46 was most common (n=251; 56%) of which 36 (8%) were pseudodiploid with numerical aberrations, followed by MN 47 (n=80; 18%) and MN 43-45 (n=48; 8%). No cases had MN less than 43. Hyperdiploid AML with MN 48-65 comprised 11% of all cases and was associated with early onset (median age 2 years), female sex (57%), and a dominance of acute megakaryoblastic leukemia (AMKL) (29%). Hypodiploidy constituted 8% of all AML and was associated with older age (median age 9 years), male predominance (60%), FAB M2 (56%), and t(8;21)(q22;q22) (56%) with loss of sex chromosomes. Inferior outcome was observed for hypodiploid cases (5-year event-free survival 40% and 5-year overall survival 40%) but did not reach statistical significance. Chromosomes were gained in a nonrandom pattern, where chromosomes 8, 21, 19, and 6 were the most commonly gained. In conclusion, based on MNs, two cytogenetic subgroups with characteristic clinical features are described; hypodiploidy found in 8% and associated with high median age, male sex, t(8;21)(q22;q22), and FAB M2 and possibly associated with inferior outcome (P=0.13), and hyperdiploidy with MN 48-65 in 11% associated with early onset, female sex, and AMKL.
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Kjeldsen, Eigil
(author)
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Abrahamsson, Jonas
(author)
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Ha, Shau-Yin
(author)
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Heldrup, JesperLund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)med-jrh
(author)
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Jahnukainen, Kirsi
(author)
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Jonsson, Olafur G.
(author)
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Lausen, Birgitte
(author)
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Palle, JosefineUppsala universitet,Pediatrik(Swepub:uu)jopal516
(author)
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Zeller, Bernward
(author)
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Forestier, ErikUmeå universitet,Medicinsk och klinisk genetik(Swepub:umu)erfo0007
(author)
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Hasle, Henrik
(author)
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Pediatrik, LundSektion V
(creator_code:org_t)
Related titles
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In:Genes, Chromosomes and Cancer: Wiley53:8, s. 667-6751045-22571098-2264
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Sandahl, Julie D ...
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Kjeldsen, Eigil
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Abrahamsson, Jon ...
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Ha, Shau-Yin
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Heldrup, Jesper
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Jahnukainen, Kir ...
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Jonsson, Olafur ...
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Lausen, Birgitte
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Palle, Josefine
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Zeller, Bernward
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Forestier, Erik
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Hasle, Henrik
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Pediatrics
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MEDICAL AND HEAL ...
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Uppsala University
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Umeå University
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Lund University