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  • Sandahl, Julie Damgaard (author)

Ploidy and clinical characteristics of childhood acute myeloid leukemia : A NOPHO-AML study

  • Article/chapterEnglish2014

Publisher, publication year, extent ...

  • 2014-04-18
  • Wiley,2014
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-228680
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-228680URI
  • https://doi.org/10.1002/gcc.22177DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-91181URI
  • https://lup.lub.lu.se/record/4609290URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • We report the first large series (n=596) of pediatric acute myeloid leukemia (AML) focusing on modal numbers (MN) from the population-based NOPHO-AML trials. Abnormal karyotypes were present in 452 cases (76%) and numerical aberrations were present in 40% (n=237) of all pediatric AML. Among patients with an abnormal karyotype, the MN 46 was most common (n=251; 56%) of which 36 (8%) were pseudodiploid with numerical aberrations, followed by MN 47 (n=80; 18%) and MN 43-45 (n=48; 8%). No cases had MN less than 43. Hyperdiploid AML with MN 48-65 comprised 11% of all cases and was associated with early onset (median age 2 years), female sex (57%), and a dominance of acute megakaryoblastic leukemia (AMKL) (29%). Hypodiploidy constituted 8% of all AML and was associated with older age (median age 9 years), male predominance (60%), FAB M2 (56%), and t(8;21)(q22;q22) (56%) with loss of sex chromosomes. Inferior outcome was observed for hypodiploid cases (5-year event-free survival 40% and 5-year overall survival 40%) but did not reach statistical significance. Chromosomes were gained in a nonrandom pattern, where chromosomes 8, 21, 19, and 6 were the most commonly gained. In conclusion, based on MNs, two cytogenetic subgroups with characteristic clinical features are described; hypodiploidy found in 8% and associated with high median age, male sex, t(8;21)(q22;q22), and FAB M2 and possibly associated with inferior outcome (P=0.13), and hyperdiploidy with MN 48-65 in 11% associated with early onset, female sex, and AMKL.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Kjeldsen, Eigil (author)
  • Abrahamsson, Jonas (author)
  • Ha, Shau-Yin (author)
  • Heldrup, JesperLund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)med-jrh (author)
  • Jahnukainen, Kirsi (author)
  • Jonsson, Olafur G. (author)
  • Lausen, Birgitte (author)
  • Palle, JosefineUppsala universitet,Pediatrik(Swepub:uu)jopal516 (author)
  • Zeller, Bernward (author)
  • Forestier, ErikUmeå universitet,Medicinsk och klinisk genetik(Swepub:umu)erfo0007 (author)
  • Hasle, Henrik (author)
  • Pediatrik, LundSektion V (creator_code:org_t)

Related titles

  • In:Genes, Chromosomes and Cancer: Wiley53:8, s. 667-6751045-22571098-2264

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