Search: id:"swepub:oai:DiVA.org:uu-22892" >
Paradoxical stimula...
-
Salehi, S AlbertLund University,Lunds universitet,Islet cell physiology,Forskargrupper vid Lunds universitet,Lund University Research Groups,Institutionen för klinisk vetenskap, Malmö universitetssjukhus, Lunds universitet
(author)
Paradoxical stimulation of glucagon secretion by high glucose concentrations
- Article/chapterEnglish2006
Publisher, publication year, extent ...
-
American Diabetes Association,2006
-
electronicrdacarrier
Numbers
-
LIBRIS-ID:oai:DiVA.org:uu-22892
-
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-22892URI
-
https://doi.org/10.2337/db06-0080DOI
-
https://lup.lub.lu.se/record/686336URI
Supplementary language notes
-
Language:English
-
Summary in:English
Part of subdatabase
Classification
-
Subject category:ref swepub-contenttype
-
Subject category:art swepub-publicationtype
Notes
-
Hypersecretion of glucagon contributes to the dysregulation of glucose homeostasis in diabetes. To clarify the underlying mechanism, glucose-regulated glucagon secretion was studied in mouse pancreatic islets and clonal hamster In-R1-G9 glucagon-releasing cells. Apart from the well-known inhibition of secretion with maximal effect around 7 mmol/l glucose, we discovered that mouse islets showed paradoxical stimulation of glucagon release at 25-30 mmol/l and In-R1-G9 cells at 12-20 mmol/l sugar. Whereas glucagon secretion in the absence of glucose was inhibited by hyperpolarization with diazoxide, this agent tended to further enhance secretion stimulated by high concentrations of the sugar. Because U-shaped dose-response relationships for glucose-regulated glucagon secretion were observed in normal islets and in clonal glucagon-releasing cells, both the inhibitory and stimulatory components probably reflect direct effects on the a-cells. Studies of isolated mouse a-cells indicated that glucose inhibited glucagon secretion by lowering the cytoplasmic Ca2+ concentration. However, stimulation of glucagon release by high glucose concentrations did not require elevation of Ca2+, indicating involvement of novel mechanisms in glucose regulation of glucagon secretion. A U-shaped dose-response relationship for glucose-regulated glucagon secretion may explain why diabetic patients with pronounced hyperglycemia display paradoxical hyperglucagonemia.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Vieira, ElaineUppsala universitet,Institutionen för medicinsk cellbiologi(Swepub:uu)evi27674
(author)
-
Gylfe, ErikUppsala universitet,Institutionen för medicinsk cellbiologi(Swepub:uu)erikgylf
(author)
-
Islet cell physiologyForskargrupper vid Lunds universitet
(creator_code:org_t)
Related titles
-
In:Diabetes: American Diabetes Association55:8, s. 2318-23230012-17971939-327X
Internet link
Find in a library
-
Diabetes
(Search for host publication in LIBRIS)
To the university's database