WFRF:(Nieters A)
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- Cozen, W. (author)
A meta-analysis of Hodgkin lymphoma reveals 19p13.3 TCF3 as a novel susceptibility locus
- Article/chapterEnglish2014
Publisher, publication year, extent ...
- 2014-06-12
- Springer Science and Business Media LLC,2014
- printrdacarrier
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- LIBRIS-ID:oai:DiVA.org:uu-229971
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-229971URI
- https://doi.org/10.1038/ncomms4856DOI
- http://kipublications.ki.se/Default.aspx?queryparsed=id:129387866URI
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- Language:English
- Summary in:English
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- Recent genome-wide association studies (GWAS) of Hodgkin lymphoma (HL) have identified associations with genetic variation at both HLA and non-HLA loci; however, much of heritable HL susceptibility remains unexplained. Here we perform a meta-analysis of three HL GWAS totaling 1,816 cases and 7,877 controls followed by replication in an independent set of 1,281 cases and 3,218 controls to find novel risk loci. We identify a novel variant at 19p13.3 associated with HL (rs1860661; odds ratio (OR) = 0.81, 95% confidence interval (95% CI) = 0.76-0.86, P-combined 3.5 x 10(-10)), located in intron 2 of TCF3 (also known as E2A), a regulator of B-and T-cell lineage commitment known to be involved in HL pathogenesis. This meta-analysis also notes associations between previously published loci at 2p16, 5q31, 6p31, 8q24 and 10p14 and HL subtypes. We conclude that our data suggest a link between the 19p13.3 locus, including TCF3, and HL risk.
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- Timofeeva, M. N. (author)
- Li, D. (author)
- Diepstra, A. (author)
- Hazelett, D. (author)
- Delahaye-Sourdeix, M. (author)
- Edlund, C. K. (author)
- Franke, L. (author)
- Rostgaard, K. (author)
- Van Den Berg, D. J. (author)
- Cortessis, V. K. (author)
- Smedby, K. E.Karolinska Institutet (author)
- Glaser, S. L. (author)
- Westra, H. -J (author)
- Robison, L. L. (author)
- Mack, T. M. (author)
- Ghesquieres, H. (author)
- Hwang, A. E. (author)
- Nieters, A. (author)
- de Sanjose, S. (author)
- Lightfoot, T. (author)
- Becker, N. (author)
- Maynadie, M. (author)
- Foretova, L. (author)
- Roman, E. (author)
- Benavente, Y. (author)
- Rand, K. A. (author)
- Nathwani, B. N. (author)
- Glimelius, BengtUppsala universitet,Enheten för onkologi(Swepub:uu)bengglim (author)
- Staines, A. (author)
- Boffetta, P. (author)
- Link, B. K. (author)
- Kiemeney, L. (author)
- Ansell, S. M. (author)
- Bhatia, S. (author)
- Strong, L. C. (author)
- Galan, P. (author)
- Vatten, L. (author)
- Habermann, T. M. (author)
- Duell, E. J. (author)
- Lake, A. (author)
- Veenstra, R. N. (author)
- Visser, L. (author)
- Liu, Y. (author)
- Urayama, K. Y. (author)
- Montgomery, D. (author)
- Gaborieau, V. (author)
- Weiss, L. M. (author)
- Byrnes, G. (author)
- Lathrop, M. (author)
- Cocco, P. (author)
- Best, T. (author)
- Skol, A. D. (author)
- Adami, H. -OKarolinska Institutet (author)
- Melbye, M. (author)
- Cerhan, J. R. (author)
- Gallagher, A. (author)
- Taylor, G. M. (author)
- Slager, S. L. (author)
- Brennan, P. (author)
- Coetzee, G. A. (author)
- Conti, D. V. (author)
- Onel, K. (author)
- Jarrett, R. F. (author)
- Hjalgrim, H. (author)
- van den Berg, A. (author)
- Mckay, J. D. (author)
- Karolinska InstitutetEnheten för onkologi (creator_code:org_t)
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- In:Nature Communications: Springer Science and Business Media LLC5, s. 3856-2041-1723
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- Cozen, W.
- Timofeeva, M. N.
- Li, D.
- Diepstra, A.
- Hazelett, D.
- Delahaye-Sourdei ...
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- Edlund, C. K.
- Franke, L.
- Rostgaard, K.
- Van Den Berg, D. ...
- Cortessis, V. K.
- Smedby, K. E.
- Glaser, S. L.
- Westra, H. -J
- Robison, L. L.
- Mack, T. M.
- Ghesquieres, H.
- Hwang, A. E.
- Nieters, A.
- de Sanjose, S.
- Lightfoot, T.
- Becker, N.
- Maynadie, M.
- Foretova, L.
- Roman, E.
- Benavente, Y.
- Rand, K. A.
- Nathwani, B. N.
- Glimelius, Bengt
- Staines, A.
- Boffetta, P.
- Link, B. K.
- Kiemeney, L.
- Ansell, S. M.
- Bhatia, S.
- Strong, L. C.
- Galan, P.
- Vatten, L.
- Habermann, T. M.
- Duell, E. J.
- Lake, A.
- Veenstra, R. N.
- Visser, L.
- Liu, Y.
- Urayama, K. Y.
- Montgomery, D.
- Gaborieau, V.
- Weiss, L. M.
- Byrnes, G.
- Lathrop, M.
- Cocco, P.
- Best, T.
- Skol, A. D.
- Adami, H. -O
- Melbye, M.
- Cerhan, J. R.
- Gallagher, A.
- Taylor, G. M.
- Slager, S. L.
- Brennan, P.
- Coetzee, G. A.
- Conti, D. V.
- Onel, K.
- Jarrett, R. F.
- Hjalgrim, H.
- van den Berg, A.
- Mckay, J. D.
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