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A meta-analysis of Hodgkin lymphoma reveals 19p13.3 TCF3 as a novel susceptibility locus
- Cozen, W. (author)
- Timofeeva, M. N. (author)
- Li, D. (author)
- show more...
- Diepstra, A. (author)
- Hazelett, D. (author)
- Delahaye-Sourdeix, M. (author)
- Edlund, C. K. (author)
- Franke, L. (author)
- Rostgaard, K. (author)
- Van Den Berg, D. J. (author)
- Cortessis, V. K. (author)
- Glaser, S. L. (author)
- Westra, H. -J (author)
- Robison, L. L. (author)
- Mack, T. M. (author)
- Ghesquieres, H. (author)
- Hwang, A. E. (author)
- Nieters, A. (author)
- de Sanjose, S. (author)
- Lightfoot, T. (author)
- Becker, N. (author)
- Maynadie, M. (author)
- Foretova, L. (author)
- Roman, E. (author)
- Benavente, Y. (author)
- Rand, K. A. (author)
- Nathwani, B. N. (author)
- Staines, A. (author)
- Boffetta, P. (author)
- Link, B. K. (author)
- Kiemeney, L. (author)
- Ansell, S. M. (author)
- Bhatia, S. (author)
- Strong, L. C. (author)
- Galan, P. (author)
- Vatten, L. (author)
- Habermann, T. M. (author)
- Duell, E. J. (author)
- Lake, A. (author)
- Veenstra, R. N. (author)
- Visser, L. (author)
- Liu, Y. (author)
- Urayama, K. Y. (author)
- Montgomery, D. (author)
- Gaborieau, V. (author)
- Weiss, L. M. (author)
- Byrnes, G. (author)
- Lathrop, M. (author)
- Cocco, P. (author)
- Best, T. (author)
- Skol, A. D. (author)
- Melbye, M. (author)
- Cerhan, J. R. (author)
- Gallagher, A. (author)
- Taylor, G. M. (author)
- Slager, S. L. (author)
- Brennan, P. (author)
- Coetzee, G. A. (author)
- Conti, D. V. (author)
- Onel, K. (author)
- Jarrett, R. F. (author)
- Hjalgrim, H. (author)
- van den Berg, A. (author)
- Mckay, J. D. (author)
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- (creator_code:org_t)
- 2014-06-12
- 2014
- English.
- In: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 5, s. 3856-
- Journal article (peer-reviewed)
Abstract
Subject headings
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- Recent genome-wide association studies (GWAS) of Hodgkin lymphoma (HL) have identified associations with genetic variation at both HLA and non-HLA loci; however, much of heritable HL susceptibility remains unexplained. Here we perform a meta-analysis of three HL GWAS totaling 1,816 cases and 7,877 controls followed by replication in an independent set of 1,281 cases and 3,218 controls to find novel risk loci. We identify a novel variant at 19p13.3 associated with HL (rs1860661; odds ratio (OR) = 0.81, 95% confidence interval (95% CI) = 0.76-0.86, P-combined 3.5 x 10(-10)), located in intron 2 of TCF3 (also known as E2A), a regulator of B-and T-cell lineage commitment known to be involved in HL pathogenesis. This meta-analysis also notes associations between previously published loci at 2p16, 5q31, 6p31, 8q24 and 10p14 and HL subtypes. We conclude that our data suggest a link between the 19p13.3 locus, including TCF3, and HL risk.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
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- ref (subject category)
- art (subject category)
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- By the author/editor
- Cozen, W.
- Timofeeva, M. N.
- Li, D.
- Diepstra, A.
- Hazelett, D.
- Delahaye-Sourdei ...
- show more...
- Edlund, C. K.
- Franke, L.
- Rostgaard, K.
- Van Den Berg, D. ...
- Cortessis, V. K.
- Smedby, K. E.
- Glaser, S. L.
- Westra, H. -J
- Robison, L. L.
- Mack, T. M.
- Ghesquieres, H.
- Hwang, A. E.
- Nieters, A.
- de Sanjose, S.
- Lightfoot, T.
- Becker, N.
- Maynadie, M.
- Foretova, L.
- Roman, E.
- Benavente, Y.
- Rand, K. A.
- Nathwani, B. N.
- Glimelius, Bengt
- Staines, A.
- Boffetta, P.
- Link, B. K.
- Kiemeney, L.
- Ansell, S. M.
- Bhatia, S.
- Strong, L. C.
- Galan, P.
- Vatten, L.
- Habermann, T. M.
- Duell, E. J.
- Lake, A.
- Veenstra, R. N.
- Visser, L.
- Liu, Y.
- Urayama, K. Y.
- Montgomery, D.
- Gaborieau, V.
- Weiss, L. M.
- Byrnes, G.
- Lathrop, M.
- Cocco, P.
- Best, T.
- Skol, A. D.
- Adami, H. -O
- Melbye, M.
- Cerhan, J. R.
- Gallagher, A.
- Taylor, G. M.
- Slager, S. L.
- Brennan, P.
- Coetzee, G. A.
- Conti, D. V.
- Onel, K.
- Jarrett, R. F.
- Hjalgrim, H.
- van den Berg, A.
- Mckay, J. D.
- show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Basic Medicine
- and Medical Genetics
- Articles in the publication
- Nature Communica ...
- By the university
- Uppsala University
- Karolinska Institutet
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