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Sökning: id:"swepub:oai:DiVA.org:uu-230766" > Abrogation of adeno...

  • Gao, XiangUppsala universitet,Institutionen för medicinsk cellbiologi (författare)

Abrogation of adenosine A1 receptor signaling improves metabolic regulation in mice by modulating oxidative stress and inflammatory responses

  • BokEngelska

Förlag, utgivningsår, omfång ...

  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:uu-230766
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-230766URI

Kompletterande språkuppgifter

  • Språk:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:vet swepub-contenttype
  • Ämneskategori:ovr swepub-publicationtype

Anmärkningar

  • Aims/hypothesis: Adenosine is an important regulator of metabolism, however, the role of A1receptor during aging and obesity is unclear. This study aimed at investigating the effects ofA1 signaling in modulating the metabolic function during aging. Methods: Age-matched young and aged A1-knockout (A1-/-) and wild-type (A1+/+) mice wereused. Metabolic regulation was evaluated by body composition, glucose and insulin tolerancetests. Isolated islets and islet arterioles were used to detect islet endocrine and vascularfunction. Oxidative stress and inflammation status were measured in metabolic organs andsystemically. Results: Advanced age was associated with reduced glucose clearance and insulin sensitivity, and increased white adipose tissue (VAT) in A1+/+ compared to A1-/- mice. Islet morphologyand insulin content were similar between genotypes, but relative changes in in vitro insulinrelease following glucose stimulation were reduced in aged A1+/+ compared with A1-/- mice.Islet arteriolar responses to angiotensin II were stronger in aged A1+/+ mice, this beingassociated with increased NADPH oxidase activity. Aging resulted in multiple changes inA1+/+ compared with A1-/- mice, including enhanced O2- formation in pancreas and VAT,elevated levels of circulating insulin, leptin and pro-inflammatory cytokines (TNF-α, IL-1β,IL-6 & IL-12) and accumulation of CD4+ T-cells in VAT. This was associated with impairedinsulin signaling in VAT from aged A1+/+ mice. Conclusions/interpretations: These studies emphasize that A1 receptors regulate metabolismand islet endocrine and vascular functions during aging by modulating oxidative stress andinflammatory responses.

Ämnesord och genrebeteckningar

  • type 2 diabetes
  • visceral adipose tissue
  • metabolic syndrome
  • insulin resistance
  • islet arterioles
  • inflammation and oxidative stress

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Yang, TingKarolinska Institutet,Department of Physiology & Pharmacology (författare)
  • Sandberg, MonicaUppsala universitet,Institutionen för medicinsk cellbiologi(Swepub:uu)mosan330 (författare)
  • Zollbrecht, ChristaKarolinska Institutet,Department of Physiology & Pharmacology (författare)
  • Zhang, Xing-MeiKarolinska Institutet,Department of Physiology & Pharmacology (författare)
  • Hezel, MichaelKarolinska Institutet,Department of Physiology and Pharmacology (författare)
  • Liu, MIngKarolinska Institutet,Department of Physiology and Pharmacology (författare)
  • Paleli, MariaKarolinska Institutet,Department of Physiology and Pharmacology (författare)
  • Lai, En-YinGeorgetown University, Washington DC, USA,Kidney & Vascular Research Center (författare)
  • Harris, Robert A.Karolinska Institutet,Department of Clinical Neuroscience (författare)
  • Persson, ErikUppsala universitet,Institutionen för medicinsk cellbiologi(Swepub:uu)erikpers (författare)
  • Fredholm, Bertil B.Karolinska Institutet,Department of Physiology and Pharmacology (författare)
  • Jansson, Leif (författare)
  • Carlström, MattiasKarolinska Institutet,Department of Physiology and Pharmacology (författare)
  • Uppsala universitetInstitutionen för medicinsk cellbiologi (creator_code:org_t)

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