PET imaging of adrenal cortical tumors with the 11beta-hydroxylase tracer 11C-metomidate

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Bergström, MatsUppsala University Pet-Centre, Uppsala, Sweden (author)

PET imaging of adrenal cortical tumors with the 11beta-hydroxylase tracer 11C-metomidate

Article/chapterEnglish2000

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2000
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LIBRIS-ID:oai:DiVA.org:uu-231386
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-231386URI

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Language:English
Summary in:English

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Subject category:art swepub-publicationtype

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The purpose of the study was to evaluate PET with the tracer 11C-metomidate as a method to identify adrenal cortical lesions.METHODS:PET with 11C-metomidate was performed in 15 patients with unilateral adrenal mass confirmed by CT. All patients subsequently underwent surgery, except 2 who underwent biopsy only. The lesions were histopathologically examined and diagnosed as adrenal cortical adenoma (n = 6; 3 nonfunctioning), adrenocortical carcinoma (n = 2), and nodular hyperplasia (n = 1). The remaining were noncortical lesions, including 1 pheochromocytoma, 1 myelolipoma, 2 adrenal cysts, and 2 metastases.RESULTS:All cortical lesions were easily identified because of exceedingly high uptake of 11C-metomidate, whereas the noncortical lesions showed very low uptake. High uptake was also seen in normal adrenal glands and in the stomach. The uptake was intermediate in the liver and low in other abdominal organs. Images obtained immediately after tracer injection displayed high uptake in the renal cortex and spleen. The tracer uptake in the cortical lesions increased throughout the examination. For quantitative evaluation of tracer binding in individual lesions, a model with the splenic radioactivity concentration assigned to represent nonspecific uptake was applied. Values derived with this method, however, did show the same specificity as the simpler standardized uptake value concept, with similar difference observed for cortical versus noncortical lesions.CONCLUSION:PET with 11C-metomidate has the potential to be an attractive method for the characterization of adrenal masses with the ability to discriminate lesions of adrenal cortical origin from noncortical lesions.

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Juhlin, Claes (author)
Bonasera, Tomas A (author)
Sundin, AndersUppsala universitet,Enheten för radiologi,Enheten för nuklearmedicin och PET(Swepub:uu)anderssu (author)
Rastad, Jonas (author)
Åkerström, GöranUppsala universitet,Endokrinkirurgi(Swepub:uu)goranas (author)
Långström, BengtUppsala University Pet-Centre, Uppsala, Sweden(Swepub:uu)benglang (author)
Uppsala University Pet-Centre, Uppsala, SwedenEnheten för radiologi (creator_code:org_t)

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In:Journal of Nuclear Medicine41:2, s. 275-2820161-55051535-5667

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Radiology Nuclea ...

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