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Ascaris lumbricoids...
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Hawlader, Mohammad D HDepartment of Clinical Trial and Clinical Epidemiology, Faculty of Medicine, University of Tsukuba , Tennodai, Ibaraki, Japan
(författare)
Ascaris lumbricoids Infection as a Risk Factor for Asthma and Atopy in Rural Bangladeshi Children.
- Artikel/kapitelEngelska2014
Förlag, utgivningsår, omfång ...
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Japanese Society of Tropical Medicine,2014
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-235719
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-235719URI
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https://doi.org/10.2149/tmh.2013-19DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
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Controversy persists as to whether helminth infections cause or protect against asthma and atopy. The aim of this study was to investigate the effects of helminth infection on asthma and atopy among Bangladeshi children. A total of 912 children aged 4.5 years (mean = 54.4, range = 53.5-60.8 months) participated in a cross-sectional study nested into a randomized controlled trial in Bangladesh. Ever-asthma, ever-wheezing and current wheezing were identified using the International Study of Asthma and Allergies in Childhood questionnaire. Current helminth infection was defined by the presence of helminth eggs in stools, measured by routine microscopic examination. Repeated Ascaris infection was defined by the presence of anti-Ascaris IgE ≥ 0.70 UA/ml in serum measured by the CAP-FEIA method. Atopy was defined by specific IgE to house dust mite (anti-DP IgE) ≥ 0.70 UA/ml measured by the CAP-FEIA method and/or positive skin prick test (≥ 5 mm). Anti-Ascaris IgE was significantly associated with ever asthma (odds ratio (OR) = 1.86, 95% CI: 1.14-3.04, highest vs. lowest quartile; P for trend 0.016). Anti-Ascaris IgE was also significantly associated with positive anti-DP IgE (OR = 9.89, 95% CI: 6.52-15.00, highest vs. lowest; P for trend < 0.001) and positive skin prick test (OR = 1.69, 95% CI: 1.01-2.81, highest vs. lowest, P for trend 0.076). These findings suggest that repeated Ascaris infection is a risk factor for asthma and atopy in rural Bangladeshi children. Further analysis is required to examine the mechanism of developing asthma and atopy in relation to helminth infection.
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Ma, EnboDepartment of Clinical Trial and Clinical Epidemiology, Faculty of Medicine, University of Tsukuba , Tennodai, Ibaraki, Japan
(författare)
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Noguchi, EmikoDepartment of Medical Genetics, Faculty of Medicine, University of Tsukuba , Tennodai, Ibaraki, Japan
(författare)
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Itoh, MakotoDepartment of Infection and Immunology, Aichi Medical University School of Medicine , Nagakute, Japan
(författare)
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Arifeen, Shams EInternational Centre for Diarrhoeal Diseases Research, Bangladesh (icddr,b) , Mohakhali, Dhaka, Bangladesh
(författare)
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Persson, Lars-Åke,1947-Uppsala universitet,Institutionen för kvinnors och barns hälsa,Internationell barnhälsa och nutrition(Swepub:uu)laper499
(författare)
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Moore, Sophie EMRC International Nutrition Group, Nutrition and Public Health Intervention Research Unit, Department of Epidemiology & Population Health, London School of Hygiene and Tropical Medicine, United Kingdom
(författare)
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Raqib, RubhanaInternational Centre for Diarrhoeal Diseases Research, Bangladesh (icddr,b), Mohakhali, Dhaka, Bangladesh
(författare)
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Wagatsuma, YukikoDepartment of Clinical Trial and Clinical Epidemiology, Faculty of Medicine, University of Tsukuba, Tennodai, Ibaraki, Japan
(författare)
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Department of Clinical Trial and Clinical Epidemiology, Faculty of Medicine, University of Tsukuba , Tennodai, Ibaraki, JapanDepartment of Medical Genetics, Faculty of Medicine, University of Tsukuba , Tennodai, Ibaraki, Japan
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Tropical Medicine and Health: Japanese Society of Tropical Medicine42:2, s. 77-851348-89451349-4147
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