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  • Sharma, Manish (author)

Older Patients with Myeloma Derive Similar Benefit from Autologous Transplantation

  • Article/chapterEnglish2014

Publisher, publication year, extent ...

  • Elsevier BV,2014
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-236522
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-236522URI
  • https://doi.org/10.1016/j.bbmt.2014.07.013DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:129910956URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Autologous hematopoietic cell transplantation (AHCT) for plasma cell myeloma is performed less often in people >70 years old than in people <= 70 years old. We analyzed 11,430 AHCT recipients for plasma cell myeloma prospectively reported to the Center for International Blood and Marrow Transplant Research between 2008 and 2011, representing the majority of US AHCT activity during this period. Survival (OS) was compared in 3 cohorts: ages 18 to 59 years (n = 5818), 60 to 69 years (n = 4666), and >70 years (n = 946). Median OS was not reached for any cohort. In multivariate analysis, increasing age was associated with mortality (P = .0006). Myeloma-specific mortality was similar among cohorts at 12%, indicating an age-related effect on nonmyeloma mortality. Analyses were performed in a representative subgroup comparing relapse rate, progression-free survival (PFS), and nonrelapse mortality (NRM). One-year NRM was 0% for age >70 years and 2% for other ages (P = not significant). The three-year relapse rate was 56% in age 18 to 59 years, 61% in age 60 to 69 years, and 63% age >70 (P = not significant). Three-year PFS was similar at 42% in age 18 to 59 years, 38% in age 60 to 69 years, and 33% in age >70 years (P = not significant). Postrelapse survival was significantly worse for the older cohort (P = .03). Older subjects selected for AHCT derived similar antimyeloma benefit without worse NRM, relapse rate, or PFS.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Zhang, Mei-Jie (author)
  • Zhong, Xiaobo (author)
  • Abidi, Muneer H. (author)
  • Akpek, Goerguen (author)
  • Bacher, Ulrike (author)
  • Callander, Natalie S. (author)
  • Dispenzieri, Angela (author)
  • Freytes, Cesar O. (author)
  • Fung, Henry C. (author)
  • Gale, Robert Peter (author)
  • Gasparetto, Cristina (author)
  • Gibson, John (author)
  • Holmberg, Leona A. (author)
  • Kindwall-Keller, Tamila L. (author)
  • Klumpp, Thomas R. (author)
  • Krishnan, Amrita Y. (author)
  • Landau, Heather J. (author)
  • Lazarus, Hillard M. (author)
  • Lonial, Sagar (author)
  • Maiolino, Angelo (author)
  • Marks, David I. (author)
  • Mehta, Paulette (author)
  • Med, Joseph R. Mikhael (author)
  • Nishihori, Taiga (author)
  • Olsson, RichardKarolinska Institutet (author)
  • Ramanathan, Muthalagu (author)
  • Roy, Vivek (author)
  • Savani, Bipin N. (author)
  • Schouten, Harry C. (author)
  • Scott, Emma (author)
  • Tay, Jason (author)
  • To, Luen Bik (author)
  • Vesole, David H. (author)
  • Vogl, Dan T. (author)
  • Hari, Parameswaran (author)
  • Karolinska Institutet (creator_code:org_t)

Related titles

  • In:Biology of blood and marrow transplantation: Elsevier BV20:11, s. 1796-18031083-87911523-6536

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