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Human cytomegalovir...
Human cytomegalovirus tegument protein pp65 is detected in all intra- and extra-axial brain tumours independent of the tumour type or grade
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- Libard, Sylwia (author)
- Uppsala universitet,Klinisk och experimentell patologi,Irina Alfuzoff
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- Popova, Svetlana N (author)
- Uppsala universitet,Klinisk och experimentell patologi,Department of Pathology, Uppsala University Hospital, Uppsala, Sweden,Irina Alafuzoff
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- Amini, Rose-Marie (author)
- Uppsala universitet,Klinisk och experimentell patologi,Rose-Marie Amini
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- Kärjä, Vesa (author)
- Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland
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- Pietiläinen, Timo (author)
- Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland
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- Hämäläinen, Kirsi M (author)
- Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland
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- Sundström, Christer (author)
- Uppsala universitet,Klinisk och experimentell patologi,Rose-Marie Amini
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- Hesselager, Göran (author)
- Uppsala universitet,Neurokirurgi,Department of Neurosurgery, Uppsala University Hospital, Sweden
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- Bergqvist, Michael (author)
- Umeå universitet,Onkologi
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- Ekman, Simon (author)
- Uppsala universitet,Enheten för onkologi
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- Zetterling, Maria (author)
- Uppsala universitet,Neurokirurgi
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- Smits, Anja (author)
- Uppsala universitet,Neurologi
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- Nilsson, Pelle (author)
- Uppsala universitet,Neurokirurgi
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- Pfeifer, Susan, 1948- (author)
- Uppsala universitet,Pediatrik,Barnonkologisk forskning/Pfeifer
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- de Ståhl, Teresita Diaz (author)
- Karolinska Institutet
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- Enblad, Gunilla (author)
- Uppsala universitet,Enheten för onkologi
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- Ponten, Fredrik (author)
- Uppsala universitet,Klinisk och experimentell patologi,Fredrik Pontén
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- Alafuzoff, Irina (author)
- Uppsala universitet,Klinisk och experimentell patologi,Irina Alufuzoff
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(creator_code:org_t)
- 2014-09-30
- 2014
- English.
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In: PLOS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 9:9, s. e108861-
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Abstract
Subject headings
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- Human cytomegalovirus (HCMV) has been indicated being a significant oncomodulator. Recent reports have suggested that an antiviral treatment alters the outcome of a glioblastoma. We analysed the performance of commercial HCMV-antibodies applying the immunohistochemical (IHC) methods on brain sample obtained from a subject with a verified HCMV infection, on samples obtained from 14 control subjects, and on a tissue microarray block containing cores of various brain tumours. Based on these trials, we selected the best performing antibody and analysed a cohort of 417 extra- and intra-axial brain tumours such as gliomas, medulloblastomas, primary diffuse large B-cell lymphomas, and meningiomas. HCMV protein pp65 immunoreactivity was observed in all types of tumours analysed, and the IHC expression did not depend on the patient's age, gender, tumour type, or grade. The labelling pattern observed in the tumours differed from the labelling pattern observed in the tissue with an active HCMV infection. The HCMV protein was expressed in up to 90% of all the tumours investigated. Our results are in accordance with previous reports regarding the HCMV protein expression in glioblastomas and medulloblastomas. In addition, the HCMV protein expression was seen in primary brain lymphomas, low-grade gliomas, and in meningiomas. Our results indicate that the HCMV protein pp65 expression is common in intra- and extra-axial brain tumours. Thus, the assessment of the HCMV expression in tumours of various origins and pathologically altered tissue in conditions such as inflammation, infection, and even degeneration should certainly be facilitated.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Klinisk laboratoriemedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Clinical Laboratory Medicine (hsv//eng)
Keyword
- Pathology
- Patologi
Publication and Content Type
- ref (subject category)
- art (subject category)
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Libard, Sylwia
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Popova, Svetlana ...
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Amini, Rose-Mari ...
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Kärjä, Vesa
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Pietiläinen, Tim ...
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Hämäläinen, Kirs ...
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Sundström, Chris ...
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Hesselager, Göra ...
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Bergqvist, Micha ...
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Ekman, Simon
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Zetterling, Mari ...
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Smits, Anja
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Nilsson, Pelle
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Pfeifer, Susan, ...
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de Ståhl, Teresi ...
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Enblad, Gunilla
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Ponten, Fredrik
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Alafuzoff, Irina
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PLOS ONE
- By the university
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Uppsala University
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Karolinska Institutet
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Umeå University