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Predictive value of...
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Westbury, Leo D.University of Southampton,Univ Southampton, MRC Lifecourse Epidemiol Ctr, Southampton, England.
(författare)
Predictive value of sarcopenia components for all-cause mortality: findings from population-based cohorts
- Artikel/kapitelEngelska2024
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Nummerbeteckningar
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LIBRIS-ID:oai:gup.ub.gu.se/339568
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https://gup.ub.gu.se/publication/339568URI
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https://doi.org/10.1007/s40520-024-02783-xDOI
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https://lup.lub.lu.se/record/c6eb611c-9e9c-4040-a074-f57571a03e64URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-534378URI
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
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Background Low grip strength and gait speed are associated with mortality. However, investigation of the additional mortality risk explained by these measures, over and above other factors, is limited.Aim We examined whether grip strength and gait speed improve discriminative capacity for mortality over and above more readily obtainable clinical risk factors.Methods Participants from the Health, Aging and Body Composition Study, Osteoporotic Fractures in Men Study, and the Hertfordshire Cohort Study were analysed. Appendicular lean mass (ALM) was ascertained using DXA; muscle strength by grip dynamometry; and usual gait speed over 2.4-6 m. Verified deaths were recorded. Associations between sarcopenia components and mortality were examined using Cox regression with cohort as a random effect; discriminative capacity was assessed using Harrell's Concordance Index (C-index).Results Mean (SD) age of participants (n = 8362) was 73.8(5.1) years; 5231(62.6%) died during a median follow-up time of 13.3 years. Grip strength (hazard ratio (95% CI) per SD decrease: 1.14 (1.10,1.19)) and gait speed (1.21 (1.17,1.26)), but not ALM index (1.01 (0.95,1.06)), were associated with mortality in mutually-adjusted models after accounting for age, sex, BMI, smoking status, alcohol consumption, physical activity, ethnicity, education, history of fractures and falls, femoral neck bone mineral density (BMD), self-rated health, cognitive function and number of comorbidities. However, a model containing only age and sex as exposures gave a C-index (95% CI) of 0.65(0.64,0.66), which only increased to 0.67(0.67,0.68) after inclusion of grip strength and gait speed.Conclusions Grip strength and gait speed may generate only modest adjunctive risk information for mortality compared with other more readily obtainable risk factors.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Harvey, Nicholas C.University of Southampton,University of Oxford,Univ Southampton, MRC Lifecourse Epidemiol Ctr, Southampton, England.;Univ Southampton, NIHR Southampton Biomed Res Ctr, Southampton, England.;Univ Hosp Southampton NHS Fdn Trust, Southampton, England.;Univ Oxford, NIHR Oxford Biomed Res Ctr, Oxford, England.
(författare)
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Beaudart, CharlotteUniv Namur, Namur Res Inst Life Sci NARILIS, Dept Biomed Sci, Fac Med,Clin Pharmacol & Toxicol Res Unit, B-5000 Namur, Belgium.
(författare)
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Bruyere, OlivierUniversity of Liège,Univ Liege, Dept Publ Hlth, Div Epidemiol Publ Hlth & Hlth Econ, Liege, Belgium.
(författare)
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Cauley, Jane A.University of Pittsburgh,Univ Pittsburgh, Sch Publ Hlth, Dept Epidemiol, Pittsburgh, PA USA.
(författare)
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Cawthon, PeggyCalifornia Pacific Medical Center,University of California, San Francisco,Calif Pacific Med Ctr, Res Inst, San Francisco, CA USA.;Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA USA.
(författare)
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Cruz-Jentoft, Alfonso J.Hospital Ramón Y Cajal,Hosp Univ Ramon y Cajal IRYCIS, Serv Geriatr, Madrid, Spain.
(författare)
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Curtis, Elizabeth M.University of Southampton,Univ Southampton, MRC Lifecourse Epidemiol Ctr, Southampton, England.
(författare)
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Ensrud, KristineUniv Minnesota, Med & Epidemiol & Community Hlth, Minneapolis, MN USA.;Minneapolis VA Hlth Care Syst, Ctr Care Delivery & Outcomes Res, Minneapolis, MN USA.,University of Minnesota
(författare)
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Fielding, Roger A.Jean Mayer USDA Human Nutrition Research Center on Aging,Tufts Univ, Jean Mayer USDA Human Nutr Res Ctr Aging, Nutr Exercise Physiol & Sarcopenia Lab, Boston, MA USA.
(författare)
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Johansson, Helena,1967University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,Australian Catholic University,Australian Catholic Univ, Mary MacKillop Inst Hlth Res, Melbourne, Australia.;Univ Gothenburg, Inst Med, Sahlgrenska Osteoporosis Ctr, Gothenburg, Sweden.(Swepub:gu)xjohhu
(författare)
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Kanis, John A.Australian Catholic University,University of Sheffield,Australian Catholic Univ, Mary MacKillop Inst Hlth Res, Melbourne, Australia.;Univ Sheffield, Ctr Metab Bone Dis, Sheffield, England.
(författare)
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Karlsson, Magnus K.Lund University,Lunds universitet,Ortopedi,Forskargrupper vid Lunds universitet,Orthopedics,Lund University Research Groups,Skåne University Hospital,Lund Univ, Dept Clin Sci Malmö, Clin & Mol Osteoporosis Res Unit, Dept Orthoped, Malmö, Sweden.;Skane Univ Hosp, Dept Orthoped, Malmö, Sweden.(Swepub:lu)orto-mka
(författare)
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Lane, Nancy E.University of California, Davis,UC Davis Hlth, Dept Internal Med, Div Rheumatol, 4625 Second Ave, Sacramento, CA 95917 USA.
(författare)
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Lengele, LaetitiaCatholic University of Louvain,Catholic Univ Louvain, UCLouvain, Louvain Drug Res Inst, Metab & Nutr Res Grp, B-1200 Sint Lambrechts Woluwe, Belgium.
(författare)
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Lorentzon, MattiasSahlgrenska University Hospital,Australian Catholic University,Australian Catholic Univ, Mary MacKillop Inst Hlth Res, Melbourne, Australia.;Sahlgrens Univ Hosp, Inst Med, Sahlgrenska Acad, Ctr Osteoporosis Res, Mölndal, Sweden.
(författare)
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McCloskey, EugeneUniversity of Sheffield,Australian Catholic University,Australian Catholic Univ, Mary MacKillop Inst Hlth Res, Melbourne, Australia.;Univ Sheffield, Ctr Integrated Res Musculoskeletal Ageing CIMA, Mellanby Ctr Bone Res, Sheffield, England.
(författare)
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Mellström, Dan,1945Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research,Sahlgrenska Academy,Univ Gothenburg, Sahlgrenska Acad, Ctr Bone & Arthrit Res CBAR, Gothenburg, Sweden.(Swepub:gu)xmelda
(författare)
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Newman, Anne B.University of Pittsburgh,Univ Pittsburgh, Sch Publ Hlth, Dept Epidemiol, Pittsburgh, PA USA.
(författare)
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Ohlsson, Claes,1965Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,Sahlgrenska Academy,Sahlgrenska University Hospital,Univ Gothenburg, Sahlgrenska Osteoporosis Ctr, Arthrit Res Sahlgrenska Acad, Inst Med,Dept Internal Med & Clin Nutr, Gothenburg, Sweden.;Sahlgrens Univ Hosp, Dept Drug Treatment, Reg Vastra Gotaland, Gothenburg, Sweden.(Swepub:gu)xohlcl
(författare)
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Orwoll, EricOregon Health & Science University,Oregon Hlth & Sci Univ, Portland, OR USA.
(författare)
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Reginster, Jean-YvesKing Saud Univ, Coll Sci, Prot Res Chair, Biochem Dept, Riyadh, Saudi Arabia.
(författare)
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Ribom, EvaUppsala universitet,Uppsala University,Ortopedi och Handkirurgi(Swepub:uu)evlri676
(författare)
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Rosengren, Björn E.Lund University,Lunds universitet,Ortopedi,Forskargrupper vid Lunds universitet,LU profilområde: Proaktivt åldrande,Lunds universitets profilområden,Orthopedics,Lund University Research Groups,LU Profile Area: Proactive Ageing,Lund University Profile areas,Skåne University Hospital,Lund Univ, Dept Clin Sci Malmö, Clin & Mol Osteoporosis Res Unit, Dept Orthoped, Malmö, Sweden.;Skane Univ Hosp, Dept Orthoped, Malmö, Sweden.(Swepub:lu)med-brr
(författare)
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Schousboe, John T.University of Minnesota,Pk Nicollet Clin, Bloomington, MN USA.;HealthPartners Inst, Bloomington, MN USA.;Univ Minnesota, Minneapolis, MN USA.
(författare)
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Dennison, Elaine M.University of Southampton,Te Herenga Waka / Victoria University of Wellington,Univ Southampton, MRC Lifecourse Epidemiol Ctr, Southampton, England.;Univ Southampton, NIHR Southampton Biomed Res Ctr, Southampton, England.;Univ Hosp Southampton NHS Fdn Trust, Southampton, England.;Victoria Univ Wellington, Wellington, New Zealand.
(författare)
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Cooper, Cyrus
(författare)
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University of SouthamptonUniv Southampton, MRC Lifecourse Epidemiol Ctr, Southampton, England.
(creator_code:org_t)
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Ingår i:AGING CLINICAL AND EXPERIMENTAL RESEARCH: Springer36:11594-06671720-8319
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Westbury, Leo D.
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Harvey, Nicholas ...
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Beaudart, Charlo ...
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Bruyere, Olivier
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Cauley, Jane A.
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Cawthon, Peggy
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Cruz-Jentoft, Al ...
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Curtis, Elizabet ...
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Ensrud, Kristine
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Fielding, Roger ...
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Johansson, Helen ...
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Kanis, John A.
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Karlsson, Magnus ...
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Lane, Nancy E.
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Lengele, Laetiti ...
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Lorentzon, Matti ...
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McCloskey, Eugen ...
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Mellström, Dan, ...
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Newman, Anne B.
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Ohlsson, Claes, ...
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Orwoll, Eric
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Reginster, Jean- ...
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Ribom, Eva
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Rosengren, Björn ...
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Schousboe, John ...
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Dennison, Elaine ...
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Cooper, Cyrus
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