Search: (WFRF:(Teras Lauren R.)) srt2:(2014) pers:(McKay James) pers:(de Bakker Paul I. W.) >
Genome-wide associa...
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Cerhan, James R.
(author)
Genome-wide association study identifies multiple susceptibility loci for diffuse large B cell lymphoma
- Article/chapterEnglish2014
Publisher, publication year, extent ...
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2014-09-28
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Springer Science and Business Media LLC,2014
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-238436
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-238436URI
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https://doi.org/10.1038/ng.3105DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:130053526URI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Diffuse large B cell lymphoma (DLBCL) is the most common lymphoma subtype and is clinically aggressive. To identify genetic susceptibility loci for DLBCL, we conducted a meta-analysis of 3 new genome-wide association studies (GWAS) and 1 previous scan, totaling 3,857 cases and 7,666 controls of European ancestry, with additional genotyping of 9 promising SNPs in 1,359 cases and 4,557 controls. In our multi-stage analysis, five independent SNPs in four loci achieved genome-wide significance marked by rs116446171 at 6p25.3 (EXOC2; P = 2.33 x 10(-21)), rs2523607 at 6p21.33 (HLA-B; P = 2.40 x 10(-10)), rs79480871 at 2p23.3 (NCOA1; P = 4.23 x 10(-8)) and two independent SNPs, rs13255292 and rs4733601, at 8q24.21 (PVT1; P = 9.98 x 10(-13) and 3.63 x 10(-11), respectively). These data provide substantial new evidence for genetic susceptibility to this B cell malignancy and point to pathways involved in immune recognition and immune function in the pathogenesis of DLBCL.
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Berndt, Sonja I.
(author)
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Vijai, Joseph
(author)
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Ghesquieres, Herve
(author)
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McKay, James
(author)
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Wang, Sophia S.
(author)
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Wang, Zhaoming
(author)
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Yeager, Meredith
(author)
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Conde, Lucia
(author)
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de Bakker, Paul I. W.
(author)
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Nieters, Alexandra
(author)
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Cox, David
(author)
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Burdett, Laurie
(author)
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Monnereau, Alain
(author)
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Flowers, Christopher R.
(author)
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De Roos, Anneclaire J.
(author)
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Brooks-Wilson, Angela R.
(author)
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Lan, Qing
(author)
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Severi, Gianluca
(author)
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Melbye, Mads
(author)
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Gu, Jian
(author)
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Jackson, Rebecca D.
(author)
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Kane, EleanorKarolinska Institutet
(author)
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Teras, Lauren R.
(author)
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Purdue, Mark P.
(author)
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Vajdic, Claire M.
(author)
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Spinelli, John J.
(author)
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Giles, Graham G.
(author)
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Albanes, Demetrius
(author)
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Kelly, Rachel S.
(author)
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Zucca, Mariagrazia
(author)
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Bertrand, Kimberly A.
(author)
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Zeleniuch-Jacquotte, Anne
(author)
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Lawrence, Charles
(author)
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Hutchinson, Amy
(author)
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Zhi, Degui
(author)
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Habermann, Thomas M.
(author)
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Link, Brian K.
(author)
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Novak, Anne J.
(author)
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Dogan, Ahmet
(author)
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Asmann, Yan W.
(author)
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Liebow, Mark
(author)
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Thompson, Carrie A.
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Ansell, Stephen M.
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Witzig, Thomas E.
(author)
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Weiner, George J.
(author)
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Veron, Amelie S.
(author)
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Zelenika, Diana
(author)
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Tilly, Herve
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Haioun, Corinne
(author)
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Molina, Thierry Jo
(author)
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Hjalgrim, HenrikKarolinska Institutet
(author)
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Glimelius, BengtUppsala universitet,Enheten för onkologi(Swepub:uu)bengglim
(author)
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Adami, Hans-Olov
(author)
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Bracci, Paige M.
(author)
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Riby, Jacques
(author)
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Smith, Martyn T.
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Holly, Elizabeth A.
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Cozen, Wendy
(author)
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Hartge, Patricia
(author)
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Morton, Lindsay M.
(author)
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Severson, Richard K.
(author)
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Tinker, Lesley F.
(author)
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North, Kari E.
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Becker, Nikolaus
(author)
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Benavente, Yolanda
(author)
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Boffetta, Paolo
(author)
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Brennan, Paul
(author)
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Foretova, Lenka
(author)
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Maynadie, Marc
(author)
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Staines, Anthony
(author)
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Lightfoot, Tracy
(author)
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Crouch, Simon
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Smith, Alex
(author)
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Roman, Eve
(author)
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Diver, W. Ryan
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Offit, Kenneth
(author)
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Zelenetz, Andrew
(author)
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Klein, Robert J.
(author)
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Villano, Danylo J.
(author)
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Zheng, Tongzhang
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Zhang, Yawei
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Holford, Theodore R.
(author)
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Kricker, Anne
(author)
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Turner, Jenny
(author)
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Southey, Melissa C.
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Clavel, Jacqueline
(author)
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Virtamo, Jarmo
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Weinstein, Stephanie
(author)
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Riboli, Elio
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Vineis, Paolo
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Kaaks, Rudolph
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Trichopoulos, Dimitrios
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Vermeulen, Roel C. H.
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Boeing, Heiner
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Tjonneland, Anne
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Angelucci, Emanuele
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Di Lollo, Simonetta
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Rais, Marco
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Birmann, Brenda M.
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Laden, Francine
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Giovannucci, Edward
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Kraft, Peter
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Huang, Jinyan
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Ma, Baoshan
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Ye, Yuanqing
(author)
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Chiu, Brian C. H.
(author)
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Sampson, Joshua
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Liang, Liming
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Park, Ju-Hyun
(author)
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Chung, Charles C.
(author)
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Weisenburger, Dennis D.
(author)
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Chatterjee, Nilanjan
(author)
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Fraumeni, Joseph F., Jr.
(author)
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Slager, Susan L.
(author)
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Wu, Xifeng
(author)
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de Sanjose, Silvia
(author)
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Smedby, Karin E.
(author)
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Salles, Gilles
(author)
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Skibola, Christine F.
(author)
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Rothman, Nathaniel
(author)
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Chanock, Stephen J.
(author)
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Karolinska InstitutetEnheten för onkologi
(creator_code:org_t)
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In:Nature Genetics: Springer Science and Business Media LLC46:11, s. 1233-12381061-40361546-1718
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- By the author/editor
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Cerhan, James R.
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Berndt, Sonja I.
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Vijai, Joseph
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Ghesquieres, Her ...
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McKay, James
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Wang, Sophia S.
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show more...
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Wang, Zhaoming
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Yeager, Meredith
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Conde, Lucia
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de Bakker, Paul ...
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Nieters, Alexand ...
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Cox, David
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Burdett, Laurie
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Monnereau, Alain
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Flowers, Christo ...
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De Roos, Annecla ...
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Brooks-Wilson, A ...
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Lan, Qing
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Severi, Gianluca
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Melbye, Mads
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Gu, Jian
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Jackson, Rebecca ...
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Kane, Eleanor
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Teras, Lauren R.
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Purdue, Mark P.
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Vajdic, Claire M ...
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Spinelli, John J ...
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Giles, Graham G.
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Albanes, Demetri ...
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Kelly, Rachel S.
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Zucca, Mariagraz ...
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Bertrand, Kimber ...
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Zeleniuch-Jacquo ...
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Lawrence, Charle ...
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Hutchinson, Amy
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Zhi, Degui
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Habermann, Thoma ...
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Link, Brian K.
-
Novak, Anne J.
-
Dogan, Ahmet
-
Asmann, Yan W.
-
Liebow, Mark
-
Thompson, Carrie ...
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Ansell, Stephen ...
-
Witzig, Thomas E ...
-
Weiner, George J ...
-
Veron, Amelie S.
-
Zelenika, Diana
-
Tilly, Herve
-
Haioun, Corinne
-
Molina, Thierry ...
-
Hjalgrim, Henrik
-
Glimelius, Bengt
-
Adami, Hans-Olov
-
Bracci, Paige M.
-
Riby, Jacques
-
Smith, Martyn T.
-
Holly, Elizabeth ...
-
Cozen, Wendy
-
Hartge, Patricia
-
Morton, Lindsay ...
-
Severson, Richar ...
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Tinker, Lesley F ...
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North, Kari E.
-
Becker, Nikolaus
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Benavente, Yolan ...
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Boffetta, Paolo
-
Brennan, Paul
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Foretova, Lenka
-
Maynadie, Marc
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Staines, Anthony
-
Lightfoot, Tracy
-
Crouch, Simon
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Smith, Alex
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Roman, Eve
-
Diver, W. Ryan
-
Offit, Kenneth
-
Zelenetz, Andrew
-
Klein, Robert J.
-
Villano, Danylo ...
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Zheng, Tongzhang
-
Zhang, Yawei
-
Holford, Theodor ...
-
Kricker, Anne
-
Turner, Jenny
-
Southey, Melissa ...
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Clavel, Jacqueli ...
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Virtamo, Jarmo
-
Weinstein, Steph ...
-
Riboli, Elio
-
Vineis, Paolo
-
Kaaks, Rudolph
-
Trichopoulos, Di ...
-
Vermeulen, Roel ...
-
Boeing, Heiner
-
Tjonneland, Anne
-
Angelucci, Emanu ...
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Di Lollo, Simone ...
-
Rais, Marco
-
Birmann, Brenda ...
-
Laden, Francine
-
Giovannucci, Edw ...
-
Kraft, Peter
-
Huang, Jinyan
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Ma, Baoshan
-
Ye, Yuanqing
-
Chiu, Brian C. H ...
-
Sampson, Joshua
-
Liang, Liming
-
Park, Ju-Hyun
-
Chung, Charles C ...
-
Weisenburger, De ...
-
Chatterjee, Nila ...
-
Fraumeni, Joseph ...
-
Slager, Susan L.
-
Wu, Xifeng
-
de Sanjose, Silv ...
-
Smedby, Karin E.
-
Salles, Gilles
-
Skibola, Christi ...
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Rothman, Nathani ...
-
Chanock, Stephen ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
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Nature Genetics
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Uppsala University
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Karolinska Institutet