Genome-wide association study identifies multiple susceptibility loci for diffuse large B cell lymphoma

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Fältnamn	Indikatorer	Metadata
000		07249naa a2201789 4500
001		oai:DiVA.org:uu-238436
003		SwePub
008		141212s2014 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:prod.swepub.kib.ki.se:130053526
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2384362 URI
024	7	a https://doi.org/10.1038/ng.31052 DOI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:1300535262 URI
040		a (SwePub)uud (SwePub)ki
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Cerhan, James R.4 aut
245	1 0	a Genome-wide association study identifies multiple susceptibility loci for diffuse large B cell lymphoma
264		c 2014-09-28
264	1	b Springer Science and Business Media LLC,c 2014
338		a print2 rdacarrier
520		a Diffuse large B cell lymphoma (DLBCL) is the most common lymphoma subtype and is clinically aggressive. To identify genetic susceptibility loci for DLBCL, we conducted a meta-analysis of 3 new genome-wide association studies (GWAS) and 1 previous scan, totaling 3,857 cases and 7,666 controls of European ancestry, with additional genotyping of 9 promising SNPs in 1,359 cases and 4,557 controls. In our multi-stage analysis, five independent SNPs in four loci achieved genome-wide significance marked by rs116446171 at 6p25.3 (EXOC2; P = 2.33 x 10(-21)), rs2523607 at 6p21.33 (HLA-B; P = 2.40 x 10(-10)), rs79480871 at 2p23.3 (NCOA1; P = 4.23 x 10(-8)) and two independent SNPs, rs13255292 and rs4733601, at 8q24.21 (PVT1; P = 9.98 x 10(-13) and 3.63 x 10(-11), respectively). These data provide substantial new evidence for genetic susceptibility to this B cell malignancy and point to pathways involved in immune recognition and immune function in the pathogenesis of DLBCL.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng
700	1	a Berndt, Sonja I.4 aut
700	1	a Vijai, Joseph4 aut
700	1	a Ghesquieres, Herve4 aut
700	1	a McKay, James4 aut
700	1	a Wang, Sophia S.4 aut
700	1	a Wang, Zhaoming4 aut
700	1	a Yeager, Meredith4 aut
700	1	a Conde, Lucia4 aut
700	1	a de Bakker, Paul I. W.4 aut
700	1	a Nieters, Alexandra4 aut
700	1	a Cox, David4 aut
700	1	a Burdett, Laurie4 aut
700	1	a Monnereau, Alain4 aut
700	1	a Flowers, Christopher R.4 aut
700	1	a De Roos, Anneclaire J.4 aut
700	1	a Brooks-Wilson, Angela R.4 aut
700	1	a Lan, Qing4 aut
700	1	a Severi, Gianluca4 aut
700	1	a Melbye, Mads4 aut
700	1	a Gu, Jian4 aut
700	1	a Jackson, Rebecca D.4 aut
700	1	a Kane, Eleanoru Karolinska Institutet4 aut
700	1	a Teras, Lauren R.4 aut
700	1	a Purdue, Mark P.4 aut
700	1	a Vajdic, Claire M.4 aut
700	1	a Spinelli, John J.4 aut
700	1	a Giles, Graham G.4 aut
700	1	a Albanes, Demetrius4 aut
700	1	a Kelly, Rachel S.4 aut
700	1	a Zucca, Mariagrazia4 aut
700	1	a Bertrand, Kimberly A.4 aut
700	1	a Zeleniuch-Jacquotte, Anne4 aut
700	1	a Lawrence, Charles4 aut
700	1	a Hutchinson, Amy4 aut
700	1	a Zhi, Degui4 aut
700	1	a Habermann, Thomas M.4 aut
700	1	a Link, Brian K.4 aut
700	1	a Novak, Anne J.4 aut
700	1	a Dogan, Ahmet4 aut
700	1	a Asmann, Yan W.4 aut
700	1	a Liebow, Mark4 aut
700	1	a Thompson, Carrie A.4 aut
700	1	a Ansell, Stephen M.4 aut
700	1	a Witzig, Thomas E.4 aut
700	1	a Weiner, George J.4 aut
700	1	a Veron, Amelie S.4 aut
700	1	a Zelenika, Diana4 aut
700	1	a Tilly, Herve4 aut
700	1	a Haioun, Corinne4 aut
700	1	a Molina, Thierry Jo4 aut
700	1	a Hjalgrim, Henriku Karolinska Institutet4 aut
700	1	a Glimelius, Bengtu Uppsala universitet,Enheten för onkologi4 aut0 (Swepub:uu)bengglim
700	1	a Adami, Hans-Olov4 aut
700	1	a Bracci, Paige M.4 aut
700	1	a Riby, Jacques4 aut
700	1	a Smith, Martyn T.4 aut
700	1	a Holly, Elizabeth A.4 aut
700	1	a Cozen, Wendy4 aut
700	1	a Hartge, Patricia4 aut
700	1	a Morton, Lindsay M.4 aut
700	1	a Severson, Richard K.4 aut
700	1	a Tinker, Lesley F.4 aut
700	1	a North, Kari E.4 aut
700	1	a Becker, Nikolaus4 aut
700	1	a Benavente, Yolanda4 aut
700	1	a Boffetta, Paolo4 aut
700	1	a Brennan, Paul4 aut
700	1	a Foretova, Lenka4 aut
700	1	a Maynadie, Marc4 aut
700	1	a Staines, Anthony4 aut
700	1	a Lightfoot, Tracy4 aut
700	1	a Crouch, Simon4 aut
700	1	a Smith, Alex4 aut
700	1	a Roman, Eve4 aut
700	1	a Diver, W. Ryan4 aut
700	1	a Offit, Kenneth4 aut
700	1	a Zelenetz, Andrew4 aut
700	1	a Klein, Robert J.4 aut
700	1	a Villano, Danylo J.4 aut
700	1	a Zheng, Tongzhang4 aut
700	1	a Zhang, Yawei4 aut
700	1	a Holford, Theodore R.4 aut
700	1	a Kricker, Anne4 aut
700	1	a Turner, Jenny4 aut
700	1	a Southey, Melissa C.4 aut
700	1	a Clavel, Jacqueline4 aut
700	1	a Virtamo, Jarmo4 aut
700	1	a Weinstein, Stephanie4 aut
700	1	a Riboli, Elio4 aut
700	1	a Vineis, Paolo4 aut
700	1	a Kaaks, Rudolph4 aut
700	1	a Trichopoulos, Dimitrios4 aut
700	1	a Vermeulen, Roel C. H.4 aut
700	1	a Boeing, Heiner4 aut
700	1	a Tjonneland, Anne4 aut
700	1	a Angelucci, Emanuele4 aut
700	1	a Di Lollo, Simonetta4 aut
700	1	a Rais, Marco4 aut
700	1	a Birmann, Brenda M.4 aut
700	1	a Laden, Francine4 aut
700	1	a Giovannucci, Edward4 aut
700	1	a Kraft, Peter4 aut
700	1	a Huang, Jinyan4 aut
700	1	a Ma, Baoshan4 aut
700	1	a Ye, Yuanqing4 aut
700	1	a Chiu, Brian C. H.4 aut
700	1	a Sampson, Joshua4 aut
700	1	a Liang, Liming4 aut
700	1	a Park, Ju-Hyun4 aut
700	1	a Chung, Charles C.4 aut
700	1	a Weisenburger, Dennis D.4 aut
700	1	a Chatterjee, Nilanjan4 aut
700	1	a Fraumeni, Joseph F., Jr.4 aut
700	1	a Slager, Susan L.4 aut
700	1	a Wu, Xifeng4 aut
700	1	a de Sanjose, Silvia4 aut
700	1	a Smedby, Karin E.4 aut
700	1	a Salles, Gilles4 aut
700	1	a Skibola, Christine F.4 aut
700	1	a Rothman, Nathaniel4 aut
700	1	a Chanock, Stephen J.4 aut
710	2	a Karolinska Institutetb Enheten för onkologi4 org
773	0	t Nature Geneticsd : Springer Science and Business Media LLCg 46:11, s. 1233-1238q 46:11<1233-1238x 1061-4036x 1546-1718
856	4	u https://europepmc.org/articles/pmc4213349?pdf=render
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-238436
856	4 8	u https://doi.org/10.1038/ng.3105
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:130053526

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Av författaren/redakt...: Cerhan, James R.; Berndt, Sonja I.; Vijai, Joseph; Ghesquieres, Her ...; McKay, James; Wang, Sophia S.; visa fler...; Wang, Zhaoming; Yeager, Meredith; Conde, Lucia; de Bakker, Paul ...; Nieters, Alexand ...; Cox, David; Burdett, Laurie; Monnereau, Alain; Flowers, Christo ...; De Roos, Annecla ...; Brooks-Wilson, A ...; Lan, Qing; Severi, Gianluca; Melbye, Mads; Gu, Jian; Jackson, Rebecca ...; Kane, Eleanor; Teras, Lauren R.; Purdue, Mark P.; Vajdic, Claire M ...; Spinelli, John J ...; Giles, Graham G.; Albanes, Demetri ...; Kelly, Rachel S.; Zucca, Mariagraz ...; Bertrand, Kimber ...; Zeleniuch-Jacquo ...; Lawrence, Charle ...; Hutchinson, Amy; Zhi, Degui; Habermann, Thoma ...; Link, Brian K.; Novak, Anne J.; Dogan, Ahmet; Asmann, Yan W.; Liebow, Mark; Thompson, Carrie ...; Ansell, Stephen ...; Witzig, Thomas E ...; Weiner, George J ...; Veron, Amelie S.; Zelenika, Diana; Tilly, Herve; Haioun, Corinne; Molina, Thierry ...; Hjalgrim, Henrik; Glimelius, Bengt; Adami, Hans-Olov; Bracci, Paige M.; Riby, Jacques; Smith, Martyn T.; Holly, Elizabeth ...; Cozen, Wendy; Hartge, Patricia; Morton, Lindsay ...; Severson, Richar ...; Tinker, Lesley F ...; North, Kari E.; Becker, Nikolaus; Benavente, Yolan ...; Boffetta, Paolo; Brennan, Paul; Foretova, Lenka; Maynadie, Marc; Staines, Anthony; Lightfoot, Tracy; Crouch, Simon; Smith, Alex; Roman, Eve; Diver, W. Ryan; Offit, Kenneth; Zelenetz, Andrew; Klein, Robert J.; Villano, Danylo ...; Zheng, Tongzhang; Zhang, Yawei; Holford, Theodor ...; Kricker, Anne; Turner, Jenny; Southey, Melissa ...; Clavel, Jacqueli ...; Virtamo, Jarmo; Weinstein, Steph ...; Riboli, Elio; Vineis, Paolo; Kaaks, Rudolph; Trichopoulos, Di ...; Vermeulen, Roel ...; Boeing, Heiner; Tjonneland, Anne; Angelucci, Emanu ...; Di Lollo, Simone ...; Rais, Marco; Birmann, Brenda ...; Laden, Francine; Giovannucci, Edw ...; Kraft, Peter; Huang, Jinyan; Ma, Baoshan; Ye, Yuanqing; Chiu, Brian C. H ...; Sampson, Joshua; Liang, Liming; Park, Ju-Hyun; Chung, Charles C ...; Weisenburger, De ...; Chatterjee, Nila ...; Fraumeni, Joseph ...; Slager, Susan L.; Wu, Xifeng; de Sanjose, Silv ...; Smedby, Karin E.; Salles, Gilles; Skibola, Christi ...; Rothman, Nathani ...; Chanock, Stephen ...; visa färre...

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