Preserved Beta-Cell Function in Type 1 Diabetes by Mesenchymal Stromal Cells

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Carlsson, Per-OlaUppsala universitet,Institutionen för medicinsk cellbiologi,Institutionen för medicinska vetenskaper (författare)

De två sista författarna delar sistaförfattarskapet.
The retention of endogenous insulin secretion in type 1 diabetes is an attractive clinical goal, which opens possibilities for long-term restoration of glucose metabolism. Mesenchymal stromal cells (MSCs) constitute, based on animal studies, a promising interventional strategy for the disease. This prospective clinical study describes the translation of this cellular intervention strategy to patients with recent onset type 1 diabetes. Twenty adult patients with newly diagnosed type 1 diabetes were enrolled and randomized to MSC treatment or to the control group. Residual beta-cell function was analyzed as C-peptide concentrations in blood in response to a mixed meal tolerance test (MMTT) at one-year follow-up. In contrast to the patients in the control arm, who showed loss in both C-peptide peak values and C-peptide when calculated as area under the curve during the first year, these responses were preserved or even increased in the MSC-treated patients. Importantly, no side effects of MSC treatment were observed. We conclude that autologous MSC treatment in new onset type 1 diabetes constitute a safe and promising strategy to intervene in disease progression and preserve beta-cell function.

Schwarcz, Erik (författare)
Korsgren, OlleUppsala universitet,Klinisk immunologi(Swepub:uu)ollekors (författare)
Le Blanc, KatarinaKarolinska Institutet (författare)
Uppsala universitetInstitutionen för medicinsk cellbiologi (creator_code:org_t)

Ingår i:Diabetes: American Diabetes Association64:2, s. 587-5920012-17971939-327X

Av författaren/redakt...: Carlsson, Per-Ol ...; Schwarcz, Erik; Korsgren, Olle; Le Blanc, Katari ...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Endokrinologi oc ...

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