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Neuropathological a...
Neuropathological assessments of the pathology in frontotemporal lobar degeneration with TDP43-positive inclusions : an inter-laboratory study by the BrainNet Europe consortium
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- Alafuzoff, Irina (författare)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi
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- Pikkarainen, Maria (författare)
- Univ Eastern Finland, Dept Clin Med, Kuopio, Finland
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- Neumann, Manuela (författare)
- Univ Tubingen, German Ctr Neurodegenerat Dis, Dept Neuropatol, Tubingen, Germany; DZNE, Tubingen, Germany
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- Arzberger, Thomas (författare)
- Univ Munich, Ctr Neuropathol & Prion Res, Munich, Germany
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- Al-Sarraj, Safa (författare)
- Kings Coll Hosp London, Inst Psychiat, Dept Clin Neuropathol, London, England; MRC, London Neurodegenerat Dis Brain Bank, London, England
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- Bodi, Istvan (författare)
- Kings Coll Hosp London, Inst Psychiat, Dept Clin Neuropathol, London, England; MRC, London Neurodegenerat Dis Brain Bank, London, England
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- Bogdanovic, Nenad (författare)
- Karolinska Institutet
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- Bugiani, Orso (författare)
- IRCSS Fdn Ist Neurol Carlo Besta, Div Neuropathol & Neurol 5, Milan, Italy
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- Ferrer, Isidro (författare)
- Univ Barcelona, CEBERNED, Bellvitge Univ Hosp, Inst Neuropathol, Barcelona, Spain
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- Gelpi, Ellen (författare)
- Biobanc Hosp Clin IDIBAPS, Neurol Tissue Bank, Barcelona, Spain
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- Gentleman, Stephen (författare)
- Univ London Imperial Coll Sci Technol & Med, Dept Med, Neuropathol Unit, London, England
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- Giaccone, Giorgio (författare)
- IRCSS Fdn Ist Neurol Carlo Besta, Div Neuropathol & Neurol 5, Milan, Italy
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- Graeber, Manuel B. (författare)
- Univ Sydney, Fac Med, Sydney, NSW 2006, Australia; Univ Sydney, Fac Hlth Sci, Brain & Mind Res Inst, Sydney, NSW 2006, Australia
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- Hortobagyi, Tibor (författare)
- Univ Debrecen, Instutute Pathol, Dept Neuropathol, Debrecen, Hungary
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- Ince, Paul G. (författare)
- Univ Sheffield, Sheffield Inst Translat Neurosci, Sheffield, S Yorkshire, England
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- Ironside, James W. (författare)
- Univ Edinburgh, Western Gen Hosp, Natl CJD Res & Surveillance Unit, Edinburgh, Midlothian, Scotland
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- Kavantzas, Nikolaos (författare)
- Natl & Capodistrian Univ Athens, Dept Pathol, Athens, Greece
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- King, Andrew (författare)
- Kings Coll Hosp London, Inst Psychiat, Dept Clin Neuropathol, London, England; MRC, London Neurodegenerat Dis Brain Bank, London, England
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- Korkolopoulou, Penelope (författare)
- Natl & Capodistrian Univ Athens, Dept Pathol, Athens, Greece
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- Kovács, Gábor G. (författare)
- Med Univ Vienna, Inst Neurol, Vienna, Austria
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- Meyronet, David (författare)
- Univ Lyon, Hosp Civils Lyon, Ctr Pathol & Neuropathol Est, Lyon Neurosci Res Ctr, Lyon, France
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- Monoranu, Camelia (författare)
- Univ Wurzburg, Abt Neuropathol, Pathol Inst, D-97070 Wurzburg, Germany
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- Nilsson, Tatjana (författare)
- Karolinska Inst, Dept Geriatr, Stockholm, Sweden
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- Parchi, Piero (författare)
- Univ Bologna, Ist Sci Neurol, Dept Biomed & Neuromotor Sci, IRCCS, Bologna, Italy
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- Patsouris, Efstratios (författare)
- Natl & Capodistrian Univ Athens, Dept Pathol, Athens, Greece
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- Revesz, Tamas (författare)
- UCL Inst Neurol, Queen Sq Brain Bank, Dept Mol Neurosci, London, England
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- Roggendorf, Wolfgang (författare)
- Univ Wurzburg, Abt Neuropathol, Pathol Inst, D-97070 Wurzburg, Germany
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- Rozemuller, Annemieke (författare)
- Vrije Univ Amsterdam, Med Ctr, Amsterdam, Netherlands
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- Seilhean, Danielle (författare)
- Univ Paris 06, AP HP, Lab Neuropathol Raymond Escourolle, Paris, France; INSERM, Paris, France
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- Streichenberger, Nathalie (författare)
- Univ Lyon, Hosp Civils Lyon, Ctr Pathol & Neuropathol Est, Lyon Neurosci Res Ctr, Lyon, France
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- Thal, Dietmar R. (författare)
- Univ Ulm, Inst Pathol, Neuropathol Lab, D-89069 Ulm, Germany
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- Wharton, Stephen B. (författare)
- Univ Sheffield, Sheffield Inst Translat Neurosci, Sheffield, S Yorkshire, England
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- Kretzschmar, Hans (författare)
- Univ Munich, Ctr Neuropathol & Prion Res, Munich, Germany
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(creator_code:org_t)
- 2014-09-20
- 2015
- Engelska.
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Ingår i: Journal of neural transmission. - : Springer Science and Business Media LLC. - 0300-9564 .- 1435-1463. ; 122:7, s. 957-972
- Relaterad länk:
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http://hdl.handle.ne...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- The BrainNet Europe consortium assessed the reproducibility in the assignment of the type of frontotemporal lobar degeneration (FTLD) with TAR DNA-binding protein (TDP) 43 following current recommendations. The agreement rates were influenced by the immunohistochemical (IHC) method and by the classification strategy followed. p62-IHC staining yielded good uniform quality of stains, but the most reliable results were obtained implementing specific Abs directed against the hallmark protein TDP43. Both assessment of the type and the extent of lesions were influenced by the Abs and by the quality of stain. Assessment of the extent of the lesions yielded poor results repeatedly; thus, the extent of pathology should not be used in diagnostic consensus criteria. Whilst 31 neuropathologists typed 30 FTLD-TDP cases, inter-rater agreement ranged from 19 to 100 per cent, being highest when applying phosphorylated TDP43/IHC. The agreement was highest when designating Type C or Type A/B. In contrast, there was a poor agreement when attempting to separate Type A or Type B FTLD-TDP. In conclusion, we can expect that neuropathologist, independent of his/her familiarity with FTLD-TDP pathology, can identify a TDP43-positive FTLD case. The goal should be to state a Type (A, B, C, D) or a mixture of Types (A/B, A/C or B/C). Neuropathologists, other clinicians and researchers should be aware of the pitfalls whilst doing so. Agreement can be reached in an inter-laboratory setting regarding Type C cases with thick and long neurites, whereas the differentiation between Types A and B may be more troublesome.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- Ubiquitin; p62; TDP43; Phosphorylated TDP43; FTLD-TDP; BrainNet Europe; Immunohistochemistry; Inter-laboratory study; Tissue
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Alafuzoff, Irina
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Pikkarainen, Mar ...
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Neumann, Manuela
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Arzberger, Thoma ...
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Al-Sarraj, Safa
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Bodi, Istvan
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visa fler...
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Bogdanovic, Nena ...
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Bugiani, Orso
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Ferrer, Isidro
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Gelpi, Ellen
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Gentleman, Steph ...
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Giaccone, Giorgi ...
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Graeber, Manuel ...
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Hortobagyi, Tibo ...
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Ince, Paul G.
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Ironside, James ...
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Kavantzas, Nikol ...
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King, Andrew
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Korkolopoulou, P ...
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Kovács, Gábor G.
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Meyronet, David
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Monoranu, Cameli ...
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Nilsson, Tatjana
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Parchi, Piero
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Patsouris, Efstr ...
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Revesz, Tamas
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Roggendorf, Wolf ...
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Rozemuller, Anne ...
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Seilhean, Daniel ...
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Streichenberger, ...
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Thal, Dietmar R.
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Wharton, Stephen ...
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Kretzschmar, Han ...
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- MEDICIN OCH HÄLSOVETENSKAP
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och Neurovetenskaper
- Artiklar i publikationen
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Journal of neura ...
- Av lärosätet
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Uppsala universitet
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Karolinska Institutet