L773:1399 543X OR L773:1399 5448
Sökning: L773:1399 543X OR L773:1399 5448 > (2015-2019) > Does treatment with...
- Brorsson, Anna Lena,1964-Karolinska Institutet,Karolinska institutet (författare)
Does treatment with an insulin pump improve glycaemic control in children and adolescents with type 1 diabetes? : A retrospective case-control study
- Artikel/kapitelEngelska2015
Förlag, utgivningsår, omfång ...
- 2014-10-20
- Hindawi Limited,2015
- printrdacarrier
Nummerbeteckningar
- LIBRIS-ID:oai:DiVA.org:uu-239774
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-239774URI
- https://doi.org/10.1111/pedi.12209DOI
- http://kipublications.ki.se/Default.aspx?queryparsed=id:132162951URI
- https://urn.kb.se/resolve?urn=urn:nbn:se:du-27247URI
Kompletterande språkuppgifter
- Språk:engelska
- Sammanfattning på:engelska
Ingår i deldatabas
- SwePubSwePub
Klassifikation
Anmärkningar
- OBJECTIVE: To investigate long-term effects on glycaemic control, ketoacidosis, serious hypoglycaemic events, insulin requirements, and body mass index standard deviation scores (BMI-SDS) in children and adolescents with type 1 diabetes starting on continuous subcutaneous insulin infusion (CSII) compared with children and adolescents treated with multiple daily injections (MDI).METHODS: This retrospective case-control study compares 216 patients starting CSII with a control group on MDI (n = 215), matched for glycated hemoglobin (HbA1c), sex, and age during a 2-yr period. Variables collected were gender, age, HbA1c, insulin requirement, BMI, BMI-SDS, ketoacidosis, and serious hypoglycaemic events.RESULTS: In the CSII group there was an improvement in HbA1c after 6 and 12 months compared with the MDI group. For boys and girls separately the same effect was detected after 6 months, but only for boys after 12 months. The incidence of ketoacidosis was higher in the CSII group compared with the MDI group (2.8 vs. 0.5/100 person-yr). The incidences of severe hypoglycaemic episodes per 100 person-yr were three in the CSII group and six in the MDI group (p < 0.05). After 6, 12, and 24 months, the insulin requirement was higher in the MDI group.CONCLUSIONS: This study shows that treatment with CSII resulted in an improvement in HbA1c levels up to 1 yr and decreased the number of severe hypoglycaemic events, but the frequency of ketoacidosis increased. The major challenge is to identify methods to maintain the HbA1c improvement, especially among older children and teenagers, and reduce the frequency of ketoacidosis.
Ämnesord och genrebeteckningar
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Endokrinologi och diabetes hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Endocrinology and Diabetes hsv//eng
- adolescent
- case-control studies
- child
- diabetes mellitus type 1
- insulin infusion systems
Biuppslag (personer, institutioner, konferenser, titlar ...)
- Viklund, GunnelKarolinska Institutet (författare)
- Örtqvist, EvaKarolinska Institutet (författare)
- Lindholm Olinder, Anna,1960-Karolinska Institutet,Uppsala universitet,Klinisk diabetologi och metabolism,Karolinska Inst, Dept Clin Sci & Educ, Stockholm, Sweden(Swepub:uu)annli614 (författare)
- Karolinska InstitutetKarolinska institutet (creator_code:org_t)
Sammanhörande titlar
- Ingår i:Pediatric Diabetes: Hindawi Limited16:7, s. 546-5531399-543X1399-5448
Internetlänk
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