Sökning: WFRF:(Kristensen Maria M.) >
The Effects of a GL...
The Effects of a GLP-1 Analog on Glucose Homeostasis in Type 2 Diabetes Mellitus Quantified by an Integrated Glucose Insulin Model
-
- Røge, Rikke M (författare)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap,Pharmacometrics
-
Klim, Søren (författare)
-
Ingwersen, Steen H (författare)
-
visa fler...
-
- Kjellsson, Maria C, 1975- (författare)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap,Ph
-
Kristensen, Niels R (författare)
-
visa färre...
-
(creator_code:org_t)
- 2014-12-30
- 2015
- Engelska.
-
Ingår i: CPT. - : Wiley. - 2163-8306. ; 4:1, s. 1-9
- Relaterad länk:
-
https://uu.diva-port... (primary) (Raw object)
-
visa fler...
-
https://ascpt.online...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- In recent years, several glucagon-like peptide-1 (GLP-1)-based therapies for the treatment of type 2 diabetes mellitus (T2DM) have been developed. The aim of this work was to extend the semimechanistic integrated glucose-insulin model to include the effects of a GLP-1 analog on glucose homeostasis in T2DM patients. Data from two trials comparing the effect of steady-state liraglutide vs. placebo on the responses of postprandial glucose and insulin in T2DM patients were used for model development. The effect of liraglutide was incorporated in the model by including a stimulatory effect on insulin secretion. Furthermore, for one of the trials an inhibitory effect on glucose absorption was included to account for a delay in gastric emptying. As other GLP-1 receptor agonists have similar modes of action, it is believed that the model can also be used to describe the effect of other receptor agonists on glucose homeostasis.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
Nyckelord
- Farmakokinetik och läkemedelsterapi
- Pharmacokinetics and Drug Therapy
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
-
CPT
(Sök värdpublikationen i LIBRIS)
Till lärosätets databas