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Effects of Tigecycl...
Effects of Tigecycline and Doxycycline on Inflammation and Hemodynamics in Porcine Endotoxemia : a Prospective, Randomized and Placebo Controlled Trial
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- von Seth, Magnus (author)
- Uppsala universitet,Anestesiologi och intensivvård
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- Sjölin, Jan (author)
- Uppsala universitet,Infektionssjukdomar
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- Larsson, Anders (author)
- Uppsala universitet,Biokemisk struktur och funktion
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- Eriksson, Mats (author)
- Uppsala universitet,Anestesiologi och intensivvård
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- Hillered, Lars (author)
- Uppsala universitet,Neurokirurgi
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- Lipcsey, Miklós (author)
- Uppsala universitet,Anestesiologi och intensivvård
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(creator_code:org_t)
- 2015
- 2015
- English.
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In: Shock. - 1073-2322 .- 1540-0514. ; 43:6, s. 604-611
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- BACKGROUND: Antibiotics might, apart from an antimicrobial effect, also exert anti-inflammatory effects. The novel antibiotic tigecycline, potentially useful in septic shock from Gram-negative multi-resistant bacteria, is structurally related to antibiotics with known anti-inflammatory properties. However, its anti-inflammatory effects have previously not been explored in vivo. Using a sterile integrative porcine sepsis model, we investigated the anti-inflammatory and circulatory effects of tigecycline in comparison to doxycycline and placebo.METHODS: Eighteen pigs were randomized to receive tigecycline 100 mg, doxycycline 200 mg or placebo and subjected to 6 h endotoxin infusion at 0.5 μg x kg x h. Markers of inflammation, nitric oxide (NO) production, vascular permeability, hemodynamics, organ dysfunction, tissue metabolism and acid-base parameters were monitored.RESULTS: Peak plasma tumor necrosis alpha (TNF-α) was lower in the doxycycline group (P=0.031) but not in the tigecycline group (P=0.86) compared to placebo with geometric mean plasma concentrations of 16, 79 and 63 ng x ml, respectively. Mean arterial pressure was higher 4-6 h in the tigecycline group with values at 6 h of 107± 9 mmHg compared to the placebo and doxycycline groups (85 ± 27 mmHg and 90 ± 32 mmHg, respectively) (P=0.025). The white blood cell and the neutrophil granulocyte counts were less reduced in the doxycycline group, but not in the tigecycline group at 4-6 h (P=0.009 and p=0.019, respectively). Other markers of inflammation, organ dysfunction, tissue metabolism and acid-base parameters were unaffected by tigecycline.CONCLUSIONS: Consistent with known anti-inflammatory properties, doxycycline yielded decreased TNF-α levels. Tigecycline did not affect cytokine levels but counteracted hypotension and hypoperfusion.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Anestesi och intensivvård (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Anesthesiology and Intensive Care (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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