Does menopausal hormone therapy reduce myocardial infarction risk if initiated early after menopause?: A population-based case-control study

Does menopausal hormone therapy reduce myocardial infarction risk if initiated early after menopause? : A population-based case-control study

OBJECTIVE: This study aims to assess whether the timing of menopausal hormone therapy initiation in relation to onset of menopause and hormone therapy duration is associated with myocardial infarction risk.METHODS: This study was based on the Stockholm Heart Epidemiology Program, a population-based case-control study including 347 postmenopausal women who had experienced a nonfatal myocardial infarction and 499 female control individuals matched for age and residential area. Odds ratios (with 95% CIs) for myocardial infarction were calculated using logistic regression.RESULTS: Early initiation of hormone therapy (within 10 y of onset of menopause or before age 60 y), compared with never use, was associated with an odds ratio of 0.87 (95% CI, 0.58-1.30) after adjustments for lifestyle factors, body mass index, and socioeconomic status. For late initiation of hormone therapy, the corresponding odds ratio was 0.97 (95% CI, 0.53-1.76). For hormone therapy duration of 5 years or more, compared with never use, the adjusted odds ratio was 0.64 (95% CI, 0.35-1.18). For hormone therapy duration of less than 5 years, the odds ratio was 0.97 (95% CI, 0.63-1.48).CONCLUSIONS: Neither the timing of hormone therapy initiation nor the duration of therapy is significantly associated with myocardial infarction risk.

Berglund, AnitaKarolinska Institutet (författare)
Gigante, BrunaKarolinska Institutet (författare)
Landgren, Britt-Marie (författare)
de Faire, UlfKarolinska Institutet (författare)
Hallqvist, JohanUppsala universitet,Allmänmedicin och preventivmedicin(Swepub:uu)johha694 (författare)
Leander, KarinKarolinska Institutet (författare)
Karolinska InstitutetAllmänmedicin och preventivmedicin (creator_code:org_t)

Av författaren/redakt...: Carrasquilla, Ge ...; Berglund, Anita; Gigante, Bruna; Landgren, Britt- ...; de Faire, Ulf; Hallqvist, Johan; visa fler...; Leander, Karin; visa färre...

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