The locus C11orf30 increases susceptibility to poly-sensitization

A number of genetic variants have been associated with allergic sensitization, but whether these are allergen specific or increase susceptibility to poly-sensitization is unknown. Using data from the large multicentre population-based European Community Respiratory Health Survey, we assessed the association between 10 loci and specific IgE and skin prick tests to individual allergens and poly-sensitization. We found that the 10 loci associate with sensitization to different allergens in a nonspecific manner and that one in particular, C11orf30-rs2155219, doubles the risk of poly-sensitization (specific IgE/4 allergens: OR = 1.81, 95% CI 0.80-4.24; skin prick test/4+ allergens: OR = 2.27, 95% CI 1.34-3.95). The association of rs2155219 with higher levels of expression of C11orf30, which may be involved in transcription repression of interferon-stimulated genes, and its association with sensitization to multiple allergens suggest that this locus is highly relevant for atopy.

Minelli, C (author)
Guerra, S (author)
Wjst, M (author)
Probst-Hensch, N (author)
Pin, I (author)
Svanes, C (author)
Janson, ChristerUppsala universitet,Lungmedicin och allergologi(Swepub:uu)chrisjn (author)
Heinrich, J (author)
Jarvis, D L (author)
Uppsala universitetLungmedicin och allergologi (creator_code:org_t)

In:Allergy. European Journal of Allergy and Clinical Immunology: Wiley70:3, s. 328-3330105-45381398-9995

By the author/editor: Amaral, A F S; Minelli, C; Guerra, S; Wjst, M; Probst-Hensch, N; Pin, I; show more...; Svanes, C; Janson, Christer; Heinrich, J; Jarvis, D L; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Immunology in th ...

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