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Sökning: onr:"swepub:oai:lup.lub.lu.se:902796d5-431c-42d3-afb0-6219dc80d89d" > Chronic Obstructive...

  • Eapen, Mathew SujiUniversity of Tasmania (författare)

Chronic Obstructive Pulmonary Disease and Lung Cancer : Underlying Pathophysiology and New Therapeutic Modalities

  • Artikel/kapitelEngelska2018

Förlag, utgivningsår, omfång ...

  • 2018-11-03
  • Springer Science and Business Media LLC,2018

Nummerbeteckningar

  • LIBRIS-ID:oai:lup.lub.lu.se:902796d5-431c-42d3-afb0-6219dc80d89d
  • https://lup.lub.lu.se/record/902796d5-431c-42d3-afb0-6219dc80d89dURI
  • https://doi.org/10.1007/s40265-018-1001-8DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:art swepub-publicationtype
  • Ämneskategori:ref swepub-contenttype

Anmärkningar

  • Chronic obstructive pulmonary disease (COPD) and lung cancer are major lung diseases affecting millions worldwide. Both diseases have links to cigarette smoking and exert a considerable societal burden. People suffering from COPD are at higher risk of developing lung cancer than those without, and are more susceptible to poor outcomes after diagnosis and treatment. Lung cancer and COPD are closely associated, possibly sharing common traits such as an underlying genetic predisposition, epithelial and endothelial cell plasticity, dysfunctional inflammatory mechanisms including the deposition of excessive extracellular matrix, angiogenesis, susceptibility to DNA damage and cellular mutagenesis. In fact, COPD could be the driving factor for lung cancer, providing a conducive environment that propagates its evolution. In the early stages of smoking, body defences provide a combative immune/oxidative response and DNA repair mechanisms are likely to subdue these changes to a certain extent; however, in patients with COPD with lung cancer the consequences could be devastating, potentially contributing to slower postoperative recovery after lung resection and increased resistance to radiotherapy and chemotherapy. Vital to the development of new-targeted therapies is an in-depth understanding of various molecular mechanisms that are associated with both pathologies. In this comprehensive review, we provide a detailed overview of possible underlying factors that link COPD and lung cancer, and current therapeutic advances from both human and preclinical animal models that can effectively mitigate this unholy relationship.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Hansbro, Philip M.University of Technology Sydney,University of Newcastle (författare)
  • Larsson‑Callerfelt, Anna KarinLund University,Lunds universitet,Lungbiologi,Forskargrupper vid Lunds universitet,Lung Biology,Lund University Research Groups(Swepub:lu)med-ail (författare)
  • Jolly, Mohit K.Rice University,Indian Institute of Science (författare)
  • Myers, StephenUniversity of Tasmania (författare)
  • Sharma, PawanUniversity of Technology Sydney,University of Sydney (författare)
  • Jones, BernadetteUniversity of Technology Sydney,University of Newcastle (författare)
  • Rahman, Md AtiqurUniversity of Newcastle,University of Technology Sydney (författare)
  • Markos, JamesUniversity of Tasmania,Launceston General Hospital (författare)
  • Chia, CollinUniversity of Tasmania,Launceston General Hospital (författare)
  • Larby, JosieLaunceston General Hospital,University of Tasmania (författare)
  • Haug, GregUniversity of Tasmania,Launceston General Hospital (författare)
  • Hardikar, AshutoshUniversity of Tasmania,Royal Hobart Hospital (författare)
  • Weber, Heinrich C.North West Regional Hospital, Burnie,University of Tasmania (författare)
  • Mabeza, GeorgeUniversity of Tasmania,North West Regional Hospital, Burnie (författare)
  • Cavalheri, ViniciusCurtin University,Sir Charles Gairdner Hospital (författare)
  • Khor, Yet H.Austin Health,Alfred Hospital,University of Melbourne,Institute for Breathing and Sleep (IBAS) (författare)
  • McDonald, Christine F.Institute for Breathing and Sleep (IBAS),Austin Health,University of Melbourne (författare)
  • Sohal, Sukhwinder SinghUniversity of Tasmania (författare)
  • University of TasmaniaUniversity of Technology Sydney (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Drugs: Springer Science and Business Media LLC78:16, s. 1717-17400012-66671179-1950

Internetlänk

Hitta via bibliotek

  • Drugs (Sök värdpublikationen i LIBRIS)

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