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  • Chan, YoungUniv Sheffield, Sheffield Inst Translat Neurosci, 385A Glossop Rd, Sheffield S10 2HQ, S Yorkshire, England. (författare)

Reinnervation as measured by the motor unit size index is associated with preservation of muscle strength in amyotrophic lateral sclerosis, but not all muscles reinnervate

  • Artikel/kapitelEngelska2022

Förlag, utgivningsår, omfång ...

  • 2021-11-09
  • John Wiley & Sons,2022
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:uu-469843
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-469843URI
  • https://doi.org/10.1002/mus.27444DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

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Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Introduction/Aims: The motor unit size index (MUSIX) may provide insight into reinnervation patterns in diseases such as amyotrophic lateral sclerosis (ALS). However, it is not known whether MUSIX detects clinically relevant changes in reinnervation, or if all muscles manifest changes in MUSIX in response to reinnervation after motor unit loss.Methods: Fifty-seven patients with ALS were assessed at 3-month intervals for 12 months in four centers. Muscles examined were abductor pollicis brevis, abductor digiti minimi, biceps brachii, and tibialis anterior. Results were split into two groups: muscles with increases in MUSIX and those without increases. Longitudinal changes in MUSIX, motor unit number index (MUNIX), compound muscle action potential amplitude, and Medical Research Council strength score were investigated.Results: One hundred thirty-three muscles were examined. Fifty-nine percent of the muscles exhibited an increase in MUSIX during the study. Muscles with MUSIX increases lost more motor units (58% decline in MUNIX at 12 months, P <.001) than muscles that did not increase MUSIX (34.6% decline in MUNIX at 12 months, P <.001). However, longitudinal changes in muscle strength were similar. When motor unit loss was similar, the absence of a MUSIX increase was associated with a significantly greater loss of muscle strength (P =.002).Discussion: MUSIX increases are associated with greater motor unit loss but relative preservation of muscle strength. Thus, MUSIX appears to be measuring a clinically relevant response that can provide a quantitative outcome measure of reinnervation in clinical trials. Furthermore, MUSIX suggests that reinnervation may play a major role in determining the progression of weakness.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Alix, James J. P.Univ Sheffield, Sheffield Inst Translat Neurosci, 385A Glossop Rd, Sheffield S10 2HQ, S Yorkshire, England. (författare)
  • Neuwirth, ChristophKantonsspital, Neuromuscular Dis Unit, ALS Clin, St Gallen, Switzerland. (författare)
  • Barkhaus, Paul E.Med Coll Wisconsin, Milwaukee, WI 53226 USA. (författare)
  • Castro, JoseUniv Lisbon, Ctr Hosp Lisboa Norte, Fac Med, Dept Neurosci,Inst Med Mol,Hosp Santa Maria, Lisbon, Portugal. (författare)
  • Jenkins, Thomas M.Univ Sheffield, Sheffield Inst Translat Neurosci, 385A Glossop Rd, Sheffield S10 2HQ, S Yorkshire, England. (författare)
  • McDermott, Christopher J.Univ Sheffield, Sheffield Inst Translat Neurosci, 385A Glossop Rd, Sheffield S10 2HQ, S Yorkshire, England. (författare)
  • Shaw, Pamela J.Univ Sheffield, Sheffield Inst Translat Neurosci, 385A Glossop Rd, Sheffield S10 2HQ, S Yorkshire, England. (författare)
  • de Carvalho, MamedeUniv Lisbon, Ctr Hosp Lisboa Norte, Fac Med, Dept Neurosci,Inst Med Mol,Hosp Santa Maria, Lisbon, Portugal. (författare)
  • Nandedkar, SanjeevNatus Med Inc, Hopewell Jct, NY USA. (författare)
  • Stålberg, ErikUppsala universitet,Rostedt Punga: Klinisk neurofysiologi(Swepub:uu)eriksb (författare)
  • Weber, MarkusKantonsspital, Neuromuscular Dis Unit, ALS Clin, St Gallen, Switzerland. (författare)
  • Univ Sheffield, Sheffield Inst Translat Neurosci, 385A Glossop Rd, Sheffield S10 2HQ, S Yorkshire, England.Kantonsspital, Neuromuscular Dis Unit, ALS Clin, St Gallen, Switzerland. (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Muscle and Nerve: John Wiley & Sons65:2, s. 203-2100148-639X1097-4598

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