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Mild cognitive impa...
Mild cognitive impairment with suspected nonamyloid pathology (SNAP) Prediction of progression
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Caroli, Anna (author)
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Prestia, Annapaola (author)
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Galluzzi, Samantha (author)
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Ferrari, Clarissa (author)
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van der Flier, Wiesje M. (author)
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Ossenkoppele, Rik (author)
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Van Berckel, Bart (author)
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Barkhof, Frederik (author)
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Teunissen, Charlotte (author)
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- Wall, Anders E. (author)
- Uppsala universitet,Enheten för nuklearmedicin och PET
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- Carter, Stephen F. (author)
- Karolinska Institutet
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Schoell, Michael (author)
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Choo, Il Han (author)
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Grimmer, Timo (author)
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Redolfi, Alberto (author)
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- Nordberg, Agneta (author)
- Karolinska Institutet
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Scheltens, Philip (author)
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Drzezga, Alexander (author)
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Frisoni, Giovanni B. (author)
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(creator_code:org_t)
- 2015
- 2015
- English.
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In: Neurology. - 0028-3878 .- 1526-632X. ; 84:5, s. 508-515
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Objectives:The aim of this study was to investigate predictors of progressive cognitive deterioration in patients with suspected non-Alzheimer disease pathology (SNAP) and mild cognitive impairment (MCI).Methods:We measured markers of amyloid pathology (CSF -amyloid 42) and neurodegeneration (hippocampal volume on MRI and cortical metabolism on [F-18]-fluorodeoxyglucose-PET) in 201 patients with MCI clinically followed for up to 6 years to detect progressive cognitive deterioration. We categorized patients with MCI as A+/A- and N+/N- based on presence/absence of amyloid pathology and neurodegeneration. SNAPs were A-N+ cases.Results:The proportion of progressors was 11% (8/41), 34% (14/41), 56% (19/34), and 71% (60/85) in A-N-, A+N-, SNAP, and A+N+, respectively; the proportion of APOE epsilon 4 carriers was 29%, 70%, 31%, and 71%, respectively, with the SNAP group featuring a significantly different proportion than both A+N- and A+N+ groups (p 0.005). Hypometabolism in SNAP patients was comparable to A+N+ patients (p = 0.154), while hippocampal atrophy was more severe in SNAP patients (p = 0.002). Compared with A-N-, SNAP and A+N+ patients had significant risk of progressive cognitive deterioration (hazard ratio = 2.7 and 3.8, p = 0.016 and p < 0.001), while A+N- patients did not (hazard ratio = 1.13, p = 0.771). In A+N- and A+N+ groups, none of the biomarkers predicted time to progression. In the SNAP group, lower time to progression was correlated with greater hypometabolism (r = 0.42, p = 0.073).Conclusions:Our findings support the notion that patients with SNAP MCI feature a specific risk progression profile.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
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Neurology
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- By the author/editor
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Caroli, Anna
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Prestia, Annapao ...
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Galluzzi, Samant ...
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Ferrari, Clariss ...
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van der Flier, W ...
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Ossenkoppele, Ri ...
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show more...
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Van Berckel, Bar ...
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Barkhof, Frederi ...
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Teunissen, Charl ...
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Wall, Anders E.
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Carter, Stephen ...
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Schoell, Michael
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Choo, Il Han
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Grimmer, Timo
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Redolfi, Alberto
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Nordberg, Agneta
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Scheltens, Phili ...
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Drzezga, Alexand ...
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Frisoni, Giovann ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
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Neurology
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Uppsala University
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Karolinska Institutet