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Intrauterine death,...
Intrauterine death, fetal malformation, and delayed pregnancy in Ljungan virus-infected mice
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- Samsioe, Annika (author)
- Karolinska Institutet
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- Feinstein, Ricardo (author)
- The National Veterinary Institute, Uppsala
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- Saade, George (author)
- University of Texas, TX, USA
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- Sjöholm, Åke (author)
- Karolinska Institutet
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- Hörnfeldt, Birger (author)
- Umeå universitet,Institutionen för ekologi, miljö och geovetenskap,Umeå University
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- Fundele, Reinald (author)
- Uppsala universitet,Zoologisk utvecklingsbiologi,Uppsala universitet, Zoologisk utvecklingsbiologi
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- Klitz, William (author)
- University of California, CA, USA
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- Niklasson, Bo (author)
- Uppsala universitet,Institutionen för medicinsk cellbiologi,Uppsala universitet, Institutionen för medicinsk cellbiologi
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(creator_code:org_t)
- 2006
- 2006
- English.
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In: Birth defects research. Part B. Developmental and reproductice toxicology. - : Wiley. - 1542-9733 .- 1542-9741. ; 77:4, s. 251-256
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http://www.ncbi.nlm....
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- BACKGROUND: A picornavirus (Ljunganvirus [LV]) has recently been associated with disease during pregnancy in its natural rodent reservoir and in humans. A study of laboratory mice infected under controlled conditions was therefore undertaken. METHODS: CD-1 female mice were infected gestational day two and subjected to varying regimes of stress. RESULTS: LV infection in combination with stress resulted in uterine resorptions, malformations, and neonatal death. A short delay in time to first pregnancy and births was observed in pairs infected in utero. CONCLUSIONS: LV is found in different species of native animals in both Europe and the United States and human epidemiological evidence connects LV and human reproduction, while the observations here indicate that LV is responsible for reproductive problems in a laboratory mouse model. The current findings suggest that the hypothesis that LV also causes disease in pregnant women and their offspring deserves further study.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Physiology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Utvecklingsbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Developmental Biology (hsv//eng)
Keyword
- Ljungan virus
- infection
- mice
- intrauterine deaths
- stress
- Physiology
- Fysiologi
- Developmental biology
- Utvecklingsbiologi
Publication and Content Type
- ref (subject category)
- art (subject category)
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