Sökning: L773:1879 1913 OR L773:0002 9149
> (2005-2009) >
Usefulness of bioma...
Usefulness of biomarkers for predicting long-term mortality in patients with diabetes mellitus and non-ST-elevation acute coronary syndromes (A GUSTO IV substudy)
-
- James, Stefan K., 1964- (författare)
- Uppsala universitet,Kardiologi
-
- Lindahl, Bertil, 1957- (författare)
- Uppsala universitet,Kardiologi
-
Timmer, Jorik R. (författare)
-
visa fler...
-
Ottervanger, Jan Paul (författare)
-
- Siegbahn, Agneta, 1947- (författare)
- Uppsala universitet,Klinisk kemi
-
- Stridsberg, Mats (författare)
- Uppsala universitet,Klinisk kemi,Biokemisk endokrinologi
-
Armstrong, Paul (författare)
-
Califf, Robert (författare)
-
- Wallentin, Lars, 1943- (författare)
- Uppsala universitet,Kardiologi
-
Simoons, Maarten L. (författare)
-
visa färre...
-
(creator_code:org_t)
- Elsevier BV, 2006
- 2006
- Engelska.
-
Ingår i: American Journal of Cardiology. - : Elsevier BV. - 0002-9149 .- 1879-1913. ; 97:2, s. 167-172
- Relaterad länk:
-
http://www.ncbi.nlm....
-
visa fler...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- The present study evaluated whether biomarkers of ischemia, inflammation, myocardial damage, and dysfunction are equally useful in patients who have diabetes mellitus (DM) for prediction of cardiac events in non-ST-elevation acute coronary syndrome (ACS). DM was present in 1,677 of 7,800 patients (21.5%) who had non-ST-elevation ACS and were included in the Fourth Global Utilization of Strategies To Open Occluded Arteries (GUSTO IV) trial. Creatinine, N-terminal pro-B-type natriuretic peptide (NT-pro-BNP), troponin T, C-reactive protein, and interleukin-6 were analyzed in serum samples that were obtained at a median of 9.5 hours from symptom onset. One-year mortality rates were 13.5% among patients who had DM (n = 227) and 6.9% among those who did not (n = 418, p < 0.001). The median level of NT-pro-BNP was 2 times as high in patients who had DM, whereas troponin T levels did not differ by DM status. Mortality increased with ascending quartiles of NT-pro-BNP, with 1-year mortality rates of 3.9% (n = 11) in the bottom quartile and 29% (n = 103) in the top quartile. In multivariable analyses, factors that were predictive of 1-year mortality in patients who did not have DM were also significant for those who did. Presence of ST depression > 0.5 mm had the highest odds ratio of 2.3 (95% confidence interval 1.2 to 4.6). NT-pro-BNP levels > 669 ng/L (odds ratio 2.0, 95% confidence interval 1.1 to 3.6) and interleukin-6 levels > 10 ng/L (odds ratio 1.9, 95% confidence interval 1.2 to 3.0) were significant biomarker predictors. In conclusion, DM confers a high long-term mortality in non-ST-elevation ACS. Despite a larger proportion of ST depression and increased levels of NT-pro-BNP and interleukin-6 at admission, these factors provide independent prognostic information that may improve risk stratification and guidance of treatment.
Nyckelord
- Aged
- Biological Markers
- C-Reactive Protein
- Diabetes Mellitus/blood/*mortality
- Diabetic Angiopathies/blood/*mortality
- Female
- Humans
- Interleukin-6/blood
- Logistic Models
- Male
- Middle Aged
- Myocardial Infarction/blood/*mortality
- Natriuretic Peptide; Brain/blood
- Peptide Fragments/blood
- Prognosis
- Retrospective Studies
- Risk Assessment
- Survival Analysis
- Syndrome
- Troponin T
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
James, Stefan K. ...
-
Lindahl, Bertil, ...
-
Timmer, Jorik R.
-
Ottervanger, Jan ...
-
Siegbahn, Agneta ...
-
Stridsberg, Mats
-
visa fler...
-
Armstrong, Paul
-
Califf, Robert
-
Wallentin, Lars, ...
-
Simoons, Maarten ...
-
visa färre...
- Artiklar i publikationen
-
American Journal ...
- Av lärosätet
-
Uppsala universitet