Age- and sex-specific causal effects of adiposity on cardiovascular risk factors

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Fall, ToveUppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab (author)

Age- and sex-specific causal effects of adiposity on cardiovascular risk factors

Article/chapterEnglish2015

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2015-02-23
American Diabetes Association,2015
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LIBRIS-ID:oai:DiVA.org:uu-252379
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-252379URI
https://doi.org/10.2337/db14-0988DOI
https://lup.lub.lu.se/record/5142762URI
http://kipublications.ki.se/Default.aspx?queryparsed=id:131119833URI

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Language:English
Summary in:English

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SwePubSwePub

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

T.V. and S.H. contributed equally to this work.
Observational studies have reported different effects of adiposity on cardiovascular risk factors across age and sex. Since cardiovascular risk factors are enriched in obese individuals, it has not been easy to dissect the effects of adiposity from those of other risk factors. We used a Mendelian randomization approach, applying a set of 32 genetic markers to estimate the causal effect of adiposity on blood pressure, glycemic indices, circulating lipid levels, and markers of inflammation and liver disease in up to 67,553 individuals. All analyses were stratified by age (cutoff 55 years of age) and sex. The genetic score was associated with BMI in both nonstratified analysis (P = 2.8 × 10(-107)) and stratified analyses (all P < 3.3 × 10(-30)). We found evidence of a causal effect of adiposity on blood pressure, fasting levels of insulin, C-reactive protein, interleukin-6, HDL cholesterol, and triglycerides in a nonstratified analysis and in the <55-year stratum. Further, we found evidence of a smaller causal effect on total cholesterol (P for difference = 0.015) in the ≥55-year stratum than in the <55-year stratum, a finding that could be explained by biology, survival bias, or differential medication. In conclusion, this study extends previous knowledge of the effects of adiposity by providing sex- and age-specific causal estimates on cardiovascular risk factors.

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Hägg, SaraKarolinska Institutet,Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)sarha464 (author)
Ploner, AlexanderKarolinska Institutet (author)
Mägi, Reedik (author)
Fischer, Krista (author)
Draisma, Harmen H M (author)
Sarin, Antti-Pekka (author)
Benyamin, Beben (author)
Ladenvall, ClaesLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)med-cll (author)
Åkerlund, MikaelLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)medk-mak (author)
Kals, Mart (author)
Esko, Tõnu (author)
Nilsson, PeterLund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine(Swepub:lu)medf-pni (author)
Kaakinen, Marika (author)
Huikari, Ville (author)
Mangino, Massimo (author)
Meirhaeghe, Aline (author)
Kristiansson, KatiKarolinska Institutet (author)
Nuotio, Marja-Liisa (author)
Kobl, Michael (author)
Grallert, Harald (author)
Dehghan, Abbas (author)
Kuningas, Maris (author)
de Vries, Paul S (author)
de Bruijn, Renée F A G (author)
Willems, Sara M (author)
Heikkilä, Kauko (author)
Silventoinen, Karri (author)
Pietiläinen, Kirsi H (author)
Legry, Vanessa (author)
Giedraitis, VilmantasUppsala universitet,Geriatrik(Swepub:uu)vigie517 (author)
Goumidi, Louisa (author)
Syvänen, Ann-ChristineUppsala universitet,Molekylär medicin(Swepub:uu)anncsyva (author)
Strauch, Konstantin (author)
Koenig, Wolfgang (author)
Lichtner, Peter (author)
Herder, Christian (author)
Palotie, Aarno (author)
Menni, Cristina (author)
Uitterlinden, André G (author)
Kuulasmaa, Kari (author)
Havulinna, Aki S (author)
Moreno, Luis A (author)
Gonzalez-Gross, Marcela (author)
Evans, Alun (author)
Tregouet, David-Alexandre (author)
Yarnell, John W G (author)
Virtamo, Jarmo (author)
Ferrières, Jean (author)
Veronesi, Giovanni (author)
Perola, Markus (author)
Arveiler, Dominique (author)
Brambilla, Paolo (author)
Lind, LarsKarolinska Institutet,Uppsala universitet,Kardiovaskulär epidemiologi(Swepub:uu)larslind (author)
Kaprio, Jaakko (author)
Hofman, Albert (author)
Stricker, Bruno H (author)
van Duijn, Cornelia M (author)
Ikram, M Arfan (author)
Franco, Oscar H (author)
Cottel, Dominique (author)
Dallongeville, Jean (author)
Hall, Alistair S (author)
Jula, Antti (author)
Tobin, Martin D (author)
Penninx, Brenda W (author)
Peters, Annette (author)
Gieger, Christian (author)
Samani, Nilesh J (author)
Montgomery, Grant W (author)
Whitfield, John B (author)
Martin, Nicholas G (author)
Groop, LeifLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)endo-lgr (author)
Spector, Tim D (author)
Magnusson, Patrik K (author)
Amouyel, Philippe (author)
Boomsma, Dorret I (author)
Nilsson, Peter M (author)
Järvelin, Marjo-Riitta (author)
Lyssenko, ValeriyaLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)endo-vly (author)
Metspalu, Andres (author)
Strachan, David P (author)
Salomaa, Veikko (author)
Ripatti, Samuli (author)
Pedersen, Nancy L (author)
Prokopenko, Inga (author)
McCarthy, Mark I (author)
Ingelsson, ErikUppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)ering425 (author)
Uppsala universitetMolekylär epidemiologi (creator_code:org_t)

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In:Diabetes: American Diabetes Association64:5, s. 1841-18520012-17971939-327X

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By the author/editor: Fall, Tove; Hägg, Sara; Ploner, Alexande ...; Mägi, Reedik; Fischer, Krista; Draisma, Harmen ...; show more...; Sarin, Antti-Pek ...; Benyamin, Beben; Ladenvall, Claes; Åkerlund, Mikael; Kals, Mart; Esko, Tõnu; Nilsson, Peter; Kaakinen, Marika; Huikari, Ville; Mangino, Massimo; Meirhaeghe, Alin ...; Kristiansson, Ka ...; Nuotio, Marja-Li ...; Kobl, Michael; Grallert, Harald; Dehghan, Abbas; Kuningas, Maris; de Vries, Paul S; de Bruijn, Renée ...; Willems, Sara M; Heikkilä, Kauko; Silventoinen, Ka ...; Pietiläinen, Kir ...; Legry, Vanessa; Giedraitis, Vilm ...; Goumidi, Louisa; Syvänen, Ann-Chr ...; Strauch, Konstan ...; Koenig, Wolfgang; Lichtner, Peter; Herder, Christia ...; Palotie, Aarno; Menni, Cristina; Uitterlinden, An ...; Kuulasmaa, Kari; Havulinna, Aki S; Moreno, Luis A; Gonzalez-Gross, ...; Evans, Alun; Tregouet, David- ...; Yarnell, John W ...; Virtamo, Jarmo; Ferrières, Jean; Veronesi, Giovan ...; Perola, Markus; Arveiler, Domini ...; Brambilla, Paolo; Lind, Lars; Kaprio, Jaakko; Hofman, Albert; Stricker, Bruno ...; van Duijn, Corne ...; Ikram, M Arfan; Franco, Oscar H; Cottel, Dominiqu ...; Dallongeville, J ...; Hall, Alistair S; Jula, Antti; Tobin, Martin D; Penninx, Brenda ...; Peters, Annette; Gieger, Christia ...; Samani, Nilesh J; Montgomery, Gran ...; Whitfield, John ...; Martin, Nicholas ...; Groop, Leif; Spector, Tim D; Magnusson, Patri ...; Amouyel, Philipp ...; Boomsma, Dorret ...; Nilsson, Peter M; Järvelin, Marjo- ...; Lyssenko, Valeri ...; Metspalu, Andres; Strachan, David ...; Salomaa, Veikko; Ripatti, Samuli; Pedersen, Nancy ...; Prokopenko, Inga; McCarthy, Mark I; Ingelsson, Erik; show less...

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