Ru-Catalysed C-H Arylation of Indoles and Pyrroles with Boronic Acids: Scope and Mechanistic Studies

Ru-Catalysed C-H Arylation of Indoles and Pyrroles with Boronic Acids : Scope and Mechanistic Studies

The Ru-catalysed C2-H arylation of indoles and pyrroles by using boronic acids under oxidative conditions is reported. This reaction can be applied to tryptophan derivatives and tolerates a wide range of functional groups on both coupling partners, including bromides and iodides, which can be further derivatised selectively. New indole based ruthenacyclic complexes are described and investigated as possible intermediates in the reaction. Mechanistic studies suggest the on-cycle intermediates do not possess a para-cymene ligand and that the on-cycle metalation occurs through an electrophilic attack by the Ru centre.

Devaraj, KarthikUppsala universitet,Institutionen för kemi - BMC(Swepub:uu)karde515 (author)
Orthaber, AndreasUppsala universitet,Molekylär biomimetik(Swepub:uu)ortan368 (author)
Gates, Paul J. (author)
Pilarski, Lukasz T.Uppsala universitet,Institutionen för kemi - BMC(Swepub:uu)lukpi485 (author)
Uppsala universitetInstitutionen för kemi - BMC (creator_code:org_t)

By the author/editor: Sollert, Carina; Devaraj, Karthik; Orthaber, Andrea ...; Gates, Paul J.; Pilarski, Lukasz ...

About the subject

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.