PopED lite: an optimal design software for preclinical pharmacokinetic and pharmacodynamic studies

Aoki, Yasunori,1982-Uppsala universitet,Institutionen för farmaceutisk biovetenskap,Tillämpad matematik och statistik,Pharmacometrics Group (författare)

PopED lite : an optimal design software for preclinical pharmacokinetic and pharmacodynamic studies

Optimal experimental design approaches are seldom used in pre-clinical drug discovery. Main reasons for this lack of use are that available software tools require relatively high insight in optimal design theory, and that the design-execution cycle of in vivo experiments is short, making time-consuming optimizations infeasible. We present the publicly available software PopED lite in order to increase the use of optimal design in pre-clinical drug discovery. PopED lite is designed to be simple, fast and intuitive. Simple, to give many users access to basic optimal design calculations. Fast, to fit the short design-execution cycle and allow interactive experimental design (test one design, discuss proposed design, test another design, etc). Intuitive, so that the input to and output from the software can easily be understood by users without knowledge of the theory of optimal design. In this way, PopED lite is highly useful in practice and complements existing tools. Key functionality of PopED lite is demonstrated by three case studies from real drug discovery projects.

MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Farmaceutiska vetenskaper hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Pharmaceutical Sciences hsv//eng
NATURVETENSKAP Matematik Beräkningsmatematik hsv//swe
NATURAL SCIENCES Mathematics Computational Mathematics hsv//eng
optimal experimental design
pre-clinical drug discovery
model-based drug discovery
Matematik med inriktning mot tillämpad matematik
Mathematics with specialization in Applied Mathematics
Pharmaceutical Science
Farmaceutisk vetenskap

Sundqvist, MonikaAstraZeneca R&D,CVMD iMed DMPK (författare)
Hooker, Andrew C.Uppsala universitet,Institutionen för farmaceutisk biovetenskap,Pharmacometrics Group (författare)
Gennemark, PeterAstraZeneca R&D,CVMD iMed DMPK (författare)
Uppsala universitetInstitutionen för farmaceutisk biovetenskap (creator_code:org_t)

Av författaren/redakt...: Aoki, Yasunori, ...; Sundqvist, Monik ...; Hooker, Andrew C ...; Gennemark, Peter

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