Near infrared radiation damage mechanism in the lens

The current data strongly indicates that there is no photochemical effect of in vivo exposure to 1090 nm near IRR radiation within the pupil. Four groups of 20 Sprague-Dawley rats were unilaterally exposed in vivo to 96 W.cm(-2) centered inside the pupil for 10, 18, 33 and 60 min, respectively depending on group belonging. This resulted in radiant exposure doses of 57, 103, 198 and 344 kJ.cm(-2). Temperature evolution at the limbus during the exposure and difference of intensity of forward light scattering between the exposed and the contralateral not exposed eye was measured at 1 week after exposure. The temperature at the limbus was found to increase exponentially towards an asymptote with an asymptote temperature of around 7 degrees C and a time constant (1/k) of around 15 s. No increase of light scattering was found despite that the cumulated radiant exposure dose was [80; 250] times the threshold for photochemically induced cataract suggested by previous empirical data. It is concluded that at 1090 nm near IRR there is no photochemical effect.

Talebizadeh, NooshinUppsala universitet,Oftalmiatrik(Swepub:uu)noota977 (author)
Galichanin, KonstantinUppsala universitet,Oftalmiatrik(Swepub:uu)konga695 (author)
Kronschläger, MartinUppsala universitet,Oftalmiatrik(Swepub:uu)markr689 (author)
Schulmeister, Karl (author)
Yu, ZhaohuaUppsala universitet,Oftalmiatrik(Swepub:uu)zhayu760 (author)
Uppsala universitetOftalmiatrik (creator_code:org_t)

By the author/editor: Söderberg, Per G ...; Talebizadeh, Noo ...; Galichanin, Kons ...; Kronschläger, Ma ...; Schulmeister, Ka ...; Yu, Zhaohua

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Ophthalmology

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