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Modulation of Genet...
Modulation of Genetic Associations with Serum Urate Levels by Body-Mass-Index in Humans
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Huffman, Jennifer E. (author)
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Albrecht, Eva (author)
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Teumer, Alexander (author)
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show more...
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Mangino, Massimo (author)
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Kapur, Karen (author)
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Johnson, Toby (author)
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Kutalik, Zoltn (author)
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Pirastu, Nicola (author)
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Pistis, Giorgio (author)
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Lopez, Lorna M. (author)
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Haller, Toomas (author)
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Salo, Perttu (author)
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Goel, Anuj (author)
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Li, Man (author)
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Tanaka, Toshiko (author)
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Dehghan, Abbas (author)
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Ruggiero, Daniela (author)
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Malerba, Giovanni (author)
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Smith, Albert V. (author)
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Nolte, Ilja M. (author)
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Portas, Laura (author)
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Phipps-Green, Amanda (author)
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Boteva, Lora (author)
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Navarro, Pau (author)
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- Johansson, Åsa (author)
- Uppsala universitet,Medicinsk genetik och genomik,Uppsala kliniska forskningscentrum (UCR)
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Hicks, Andrew A. (author)
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Polasek, Ozren (author)
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Esko, Tonu (author)
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Peden, John F. (author)
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Harris, Sarah E. (author)
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Murgia, Federico (author)
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Wild, Sarah H. (author)
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Tenesa, Albert (author)
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Tin, Adrienne (author)
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Mihailov, Evelin (author)
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Grotevendt, Anne (author)
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Gislason, Gauti K. (author)
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Coresh, Josef (author)
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D'Adamo, Pio (author)
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Ulivi, Sheila (author)
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Vollenweider, Peter (author)
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Waeber, Gerard (author)
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Campbell, Susan (author)
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Kolcic, Ivana (author)
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Fisher, Krista (author)
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Viigimaa, Margus (author)
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Metter, Jeffrey E. (author)
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Masciullo, Corrado (author)
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Trabetti, Elisabetta (author)
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Bombieri, Cristina (author)
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Sorice, Rossella (author)
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Doering, Angela (author)
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Reischl, Eva (author)
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Strauch, Konstantin (author)
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Hofman, Albert (author)
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Uitterlinden, Andre G. (author)
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Waldenberger, Melanie (author)
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Wichmann, H-Erich (author)
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Davies, Gail (author)
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Gow, Alan J. (author)
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Dalbeth, Nicola (author)
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Stamp, Lisa (author)
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Smit, Johannes H. (author)
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Kirin, Mirna (author)
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Nagaraja, Ramaiah (author)
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Nauck, Matthias (author)
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Schurmann, Claudia (author)
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Budde, Kathrin (author)
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Farrington, Susan M. (author)
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Theodoratou, Evropi (author)
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Jula, Antti (author)
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Salomaa, Veikko (author)
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Sala, Cinzia (author)
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Hengstenberg, Christian (author)
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Burnier, Michel (author)
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Maegi, Reedik (author)
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Klopp, Norman (author)
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Kloiber, Stefan (author)
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Schipf, Sabine (author)
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Ripatti, Samuli (author)
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Cabras, Stefano (author)
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Soranzo, Nicole (author)
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Homuth, Georg (author)
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Nutile, Teresa (author)
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Munroe, Patricia B. (author)
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Hastie, Nicholas (author)
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Campbell, Harry (author)
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Rudan, Igor (author)
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Cabrera, Claudia (author)
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Haley, Chris (author)
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Franco, Oscar H. (author)
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Merriman, Tony R. (author)
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Gudnason, Vilmundur (author)
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Pirastu, Mario (author)
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Penninx, Brenda W. (author)
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Snieder, Harold (author)
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Metspalu, Andres (author)
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Ciullo, Marina (author)
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Pramstaller, Peter P. (author)
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van Duijn, Cornelia M. (author)
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Ferrucci, Luigi (author)
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Gambaro, Giovanni (author)
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Deary, Ian J. (author)
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Dunlop, Malcolm G. (author)
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Wilson, James F. (author)
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Gasparini, Paolo (author)
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- Gyllensten, Ulf (author)
- Uppsala universitet,Medicinsk genetik och genomik
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Spector, Tim D. (author)
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Wright, Alan F. (author)
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Hayward, Caroline (author)
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Watkins, Hugh (author)
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Perola, Markus (author)
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Bochud, Murielle (author)
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Kao, W. H. Linda (author)
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Caulfield, Mark (author)
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Toniolo, Daniela (author)
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Voelzke, Henry (author)
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Gieger, Christian (author)
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Koettgen, Anna (author)
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Vitart, Veronique (author)
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(creator_code:org_t)
- 2015-03-26
- 2015
- English.
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In: PLOS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 10:3
- Related links:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- We tested for interactions between body mass index (BMI) and common genetic variants affecting serum urate levels, genome-wide, in up to 42569 participants. Both stratified genome-wide association (GWAS) analyses, in lean, overweight and obese individuals, and regression-type analyses in a non BMI-stratified overall sample were performed. The former did not uncover any novel locus with a major main effect, but supported modulation of effects for some known and potentially new urate loci. The latter highlighted a SNP at RBFOX3 reaching genome-wide significant level (effect size 0.014, 95% CI 0.008-0.02, P-inter= 2.6 x 10(-8)). Two top loci in interaction term analyses, RBFOX3 and ERO1LB-EDAR-ADD, also displayed suggestive differences in main effect size between the lean and obese strata. All top ranking loci for urate effect differences between BMI categories were novel and most had small magnitude but opposite direction effects between strata. They include the locus RBMS1-TANK (men, Pdifflean-overweight= 4.7 x 10(-8)), a region that has been associated with several obesity related traits, and TSPYL5 (men, Pdifflean-overweight= 9.1 x 10(-8)), regulating adipocytes-produced estradiol. The top-ranking known urate loci was ABCG2, the strongest known gout risk locus, with an effect halved in obese compared to lean men (Pdifflean-obese= 2 x 10(-4)). Finally, pathway analysis suggested a role for N-glycan biosynthesis as a prominent urate-associated pathway in the lean stratum. These results illustrate a potentially powerful way to monitor changes occurring in obesogenic environment.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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PLOS ONE
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To the university's database
- By the author/editor
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Huffman, Jennife ...
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Albrecht, Eva
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Teumer, Alexande ...
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Mangino, Massimo
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Kapur, Karen
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Johnson, Toby
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show more...
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Kutalik, Zoltn
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Pirastu, Nicola
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Pistis, Giorgio
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Lopez, Lorna M.
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Haller, Toomas
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Salo, Perttu
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Goel, Anuj
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Li, Man
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Tanaka, Toshiko
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Dehghan, Abbas
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Ruggiero, Daniel ...
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Malerba, Giovann ...
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Smith, Albert V.
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Nolte, Ilja M.
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Portas, Laura
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Phipps-Green, Am ...
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Boteva, Lora
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Navarro, Pau
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Johansson, Åsa
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Hicks, Andrew A.
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Polasek, Ozren
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Esko, Tonu
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Peden, John F.
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Harris, Sarah E.
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Murgia, Federico
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Wild, Sarah H.
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Tenesa, Albert
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Tin, Adrienne
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Mihailov, Evelin
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Grotevendt, Anne
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Gislason, Gauti ...
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Coresh, Josef
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D'Adamo, Pio
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Ulivi, Sheila
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Vollenweider, Pe ...
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Waeber, Gerard
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Campbell, Susan
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Kolcic, Ivana
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Fisher, Krista
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Viigimaa, Margus
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Metter, Jeffrey ...
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Masciullo, Corra ...
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Trabetti, Elisab ...
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Bombieri, Cristi ...
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Sorice, Rossella
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Doering, Angela
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Reischl, Eva
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Strauch, Konstan ...
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Hofman, Albert
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Uitterlinden, An ...
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Waldenberger, Me ...
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Wichmann, H-Eric ...
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Davies, Gail
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Gow, Alan J.
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Dalbeth, Nicola
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Stamp, Lisa
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Smit, Johannes H ...
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Kirin, Mirna
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Nagaraja, Ramaia ...
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Nauck, Matthias
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Schurmann, Claud ...
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Budde, Kathrin
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Farrington, Susa ...
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Theodoratou, Evr ...
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Jula, Antti
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Salomaa, Veikko
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Sala, Cinzia
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Hengstenberg, Ch ...
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Burnier, Michel
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Maegi, Reedik
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Klopp, Norman
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Kloiber, Stefan
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Schipf, Sabine
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Ripatti, Samuli
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Cabras, Stefano
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Soranzo, Nicole
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Homuth, Georg
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Nutile, Teresa
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Munroe, Patricia ...
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Hastie, Nicholas
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Campbell, Harry
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Rudan, Igor
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Cabrera, Claudia
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Haley, Chris
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Franco, Oscar H.
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Merriman, Tony R ...
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Gudnason, Vilmun ...
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Pirastu, Mario
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Penninx, Brenda ...
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Snieder, Harold
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Metspalu, Andres
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Ciullo, Marina
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Pramstaller, Pet ...
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van Duijn, Corne ...
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Ferrucci, Luigi
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Gambaro, Giovann ...
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Deary, Ian J.
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Dunlop, Malcolm ...
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Wilson, James F.
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Gasparini, Paolo
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Gyllensten, Ulf
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Spector, Tim D.
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Wright, Alan F.
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Hayward, Carolin ...
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Watkins, Hugh
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Perola, Markus
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Bochud, Murielle
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Kao, W. H. Linda
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Caulfield, Mark
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Toniolo, Daniela
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Voelzke, Henry
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Gieger, Christia ...
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Koettgen, Anna
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Vitart, Veroniqu ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
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PLOS ONE
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Uppsala University