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Reference Intervals...
Reference Intervals for Insulin-like Growth Factor-1 (IGF-1) From Birth to Senescence: Results From a Multicenter Study Using a New Automated Chemiluminescence IGF-1 Immunoassay Conforming to Recent International Recommendations.
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Bidlingmaier, Martin (författare)
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Friedrich, Nele (författare)
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Emeny, Rebecca T (författare)
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Spranger, Joachim (författare)
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Wolthers, Ole D (författare)
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- Roswall, Josefine (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics
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Koerner, Antje (författare)
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Obermayer-Pietsch, Barbara (författare)
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Hübener, Christoph (författare)
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- Dahlgren, Jovanna, 1964 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics
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Frystyk, Jan (författare)
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Pfeiffer, Andreas F H (författare)
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Doering, Angela (författare)
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Bielohuby, Maximilian (författare)
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Wallaschofski, Henri (författare)
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Arafat, Ayman M (författare)
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(creator_code:org_t)
- The Endocrine Society, 2014
- 2014
- Engelska.
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Ingår i: The Journal of clinical endocrinology and metabolism. - : The Endocrine Society. - 1945-7197 .- 0021-972X. ; 99:5
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https://academic.oup...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Context: Measurement of IGF-1 is a cornerstone in diagnosis and monitoring of GH-related diseases, but considerable discrepancies exist between analytical methods. A recent consensus conference defined criteria for validation of IGF-1 assays and for establishment of normative data. Objectives: Our objectives were development and validation of a novel automated IGF-1 immunoassay (iSYS; Immunodiagnostic Systems) according to international guidelines and establishment of method-specific age- and sex-adjusted reference intervals and analysis of their robustness. Setting and Participants: We conducted a multicenter study with samples from 12 cohorts from the United States, Canada, and Europe including 15ü014 subjects (6697 males and 8317 females, 0-94 years of age). Main Outcome Measures: We measured concentrations of IGF-1 as determined by the IDS iSYS IGF-1 assay. Results: A new IGF-1 assay calibrated against the recommended standard (02/254) and insensitive to the 6 high-affinity IGF binding proteins was developed and rigorously validated. Age- and sex-adjusted reference intervals derived from a uniquely large cohort reflect the age-related pattern of IGF-1 secretion: a decline immediately after birth followed by an increase until a pubertal peak (at 15 years of age). Later in life, values decrease continuously. The impact of gender is small, although across the lifespan, women have lower mean IGF-1 concentrations. Geographical region, sampling setting (community or hospital based), and rigor of exclusion criteria in our large cohort did not affect the reference intervals. Conclusions: Using large cohorts of well-characterized subjects from different centers allowed construction of robust reference ranges for a new automated IGF-1 assay. The strict adherence to recent consensus criteria for IGF-1 assays might facilitate clinical application of the results.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
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Bidlingmaier, Ma ...
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Friedrich, Nele
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Emeny, Rebecca T
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Spranger, Joachi ...
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Wolthers, Ole D
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Roswall, Josefin ...
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visa fler...
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Koerner, Antje
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Obermayer-Pietsc ...
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Hübener, Christo ...
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Dahlgren, Jovann ...
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Frystyk, Jan
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Pfeiffer, Andrea ...
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Doering, Angela
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Bielohuby, Maxim ...
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Wallaschofski, H ...
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Arafat, Ayman M
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visa färre...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Pediatrik
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The Journal of c ...
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Göteborgs universitet