The body mass index (BMI) is significantly correlated with levels of cytokines and chemokines in cerebrospinal fluid

Cytokines and chemokines regulate many functions in the body including the brain. The interactions between adipose tissue and the central nervous system (CNS) are important for the regulation of energy balance. CNS function is also influenced by age. The aim of the present study was to investigate the effects of body mass index (BMI) and age on cytokine and chemokine levels in cerebrospinal fluid. Cerebrospinal fluid samples (n=89) were collected from patients undergoing routine surgical procedures. The samples were analyzed using the multiplex proximity extension assay (PEA) in which 92 different cytokines are measured simultaneously using minute sample volume. We found no significant correlations between age and cytokine levels for any of the studied markers. In contrast, at a false discovery rate of 10%, 19 markers were significantly associated with BMI (in decreasing significance: FGF-5, ADA, Beta-NGF, CD40, IL-10RB, CCL19, TGF-alpha, SIRT2, TWEAK, SCF, CSF-1, 4E-BP1, DNER, LIF-R, STAMPB, CXCL10, CXCL6, VEGF-A and CX3CL1). This study reveals a clear effect of BMI on cytokine and chemokine levels in cerebrospinal fluid.

Carlsson, LenaUppsala universitet,Biokemisk struktur och funktion(Swepub:uu)lenacarl (author)
Lind, Anne-LiUppsala universitet,Anestesiologi och intensivvård(Swepub:uu)annli838 (author)
Gordh, TorstenUppsala universitet,Anestesiologi och intensivvård(Swepub:uu)torsgord (author)
Bodolea, Constantin (author)
Kamali-Moghaddam, MasoodUppsala universitet,Institutionen för immunologi, genetik och patologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)masookam (author)
Thulin, MånsUppsala universitet,Statistiska institutionen(Swepub:uu)maner971 (author)
Uppsala universitetBiokemisk struktur och funktion (creator_code:org_t)

By the author/editor: Larsson, Anders; Carlsson, Lena; Lind, Anne-Li; Gordh, Torsten; Bodolea, Constan ...; Kamali-Moghaddam ...; show more...; Thulin, Måns; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Clinical Laborat ...

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