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- Chen, Yu-Chia (author)
Expression change in Angiopoietin-1 underlies change in relative brain size in fish
- Article/chapterEnglish2015
Publisher, publication year, extent ...
- 2015-07-07
- The Royal Society,2015
- electronicrdacarrier
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- LIBRIS-ID:oai:DiVA.org:uu-259653
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-259653URI
- https://doi.org/10.1098/rspb.2015.0872DOI
- https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-119295URI
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- Language:English
- Summary in:English
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Notes
- Yu-Chia Chen, Peter W. Harrison, Alexander Kotrschal, Niclas Kolm contributed equally to this work.Funding: Carl Tryggers Foundation, Austrian Science Fund J 3304-B24, Academy of Finland, Sigrid Juselius Foundation
- Brain size varies substantially across the animal kingdom and is often associated with cognitive ability; however, the genetic architecture underpinning natural variation in these key traits is virtually unknown. In order to identify the genetic architecture and loci underlying variation in brain size, we analysed both coding sequence and expression for all the loci expressed in the telencephalon in replicate populations of guppies (Poecilia reticulata) artificially selected for large and small relative brain size. A single gene, Angiopoietin-1 (Ang-1), a regulator of angiogenesis and suspected driver of neural development, was differentially expressed between large-and small-brain populations. Zebra fish (Danio rerio) morphants showed that mild knock down of Ang-1 produces a small-brained phenotype that could be rescued with Ang-1 mRNA. Translation inhibition of Ang-1 resulted in smaller brains in larvae and increased expression of Notch-1, which regulates differentiation of neural stem cells. In situ analysis of newborn large-and small-brained guppies revealed matching expression patterns of Ang-1 and Notch-1 to those observed in zebrafish larvae. Taken together, our results suggest that the genetic architecture affecting brain size in our population may be surprisingly simple, and Ang-1 may be a potentially important locus in the evolution of vertebrate brain size and cognitive ability.
Subject headings and genre
- NATURVETENSKAP Biologi Evolutionsbiologi hsv//swe
- NATURAL SCIENCES Biological Sciences Evolutionary Biology hsv//eng
- NATURVETENSKAP Biologi hsv//swe
- NATURAL SCIENCES Biological Sciences hsv//eng
- brain size
- artificial selection
- neuro-transcriptome
- gene expression
- knock down
Added entries (persons, corporate bodies, meetings, titles ...)
- Harrison, Peter W. (author)
- Kotrschal, AlexanderStockholms universitet,Uppsala universitet,Zooekologi,Avdelningen för etologi,Uppsala University, Sweden(Swepub:su)akotr (author)
- Kolm, NiclasStockholms universitet,Avdelningen för etologi,Uppsala University, Sweden(Swepub:su)nkolm (author)
- Mank, Judith E. (author)
- Panula, Pertti (author)
- Uppsala universitetZooekologi (creator_code:org_t)
Related titles
- In:Proceedings of the Royal Society of London. Biological Sciences: The Royal Society282:18100962-84521471-2954
Internet link
- https://uu.diva-portal.org/smash/get/diva2:847511/FULLTEXT01.pdffulltext:print
- https://royalsocietypublishing.org/doi/pdf/10.1098/rspb.2015.0872
- https://doi.org/10.1098/rspb.2015.0872Fulltext
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-259653
- https://doi.org/10.1098/rspb.2015.0872
- https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-119295
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