Pd-catalyzed C-N coupling of vinylbromides and sulfonimidamides: a facile synthesis of N '-vinylsulfonimidamides

Pd-catalyzed C-N coupling of vinylbromides and sulfonimidamides : a facile synthesis of N '-vinylsulfonimidamides

N'-Vinyl sulfonimidamides have been synthesized through a Pd-catalyzed C-N cross coupling between the N'-(imine nitrogen) of N'-deprotected sulfonimidamides and vinyl bromides. The hitherto unreported products were obtained in moderate to excellent yield, and the C-C double bond geometry of the vinylic substrates were retained during the course of reaction. Single crystal X-ray crystallographic analysis confirmed the product structure. Furthermore, we demonstrate that the formed N'-vinyl sulfonimidamides could undergo hydrogenation with Pd-C/H-2 to provide N'-alkyl sulfonimidamides.

Kota, Sudhakar R. (author)
Wakchaure, Prasad B.Uppsala universitet,Avdelningen för organisk farmaceutisk kemi (author)
Chinthakindi, Praveen K. (author)
Govender, Thavendran (author)
Kruger, Hendrick G. (author)
Naicker, Tricia (author)
Arvidsson, Per I.Karolinska Institutet (author)
Uppsala universitetAvdelningen för organisk farmaceutisk kemi (creator_code:org_t)

By the author/editor: Nandi, Ganesh C.; Kota, Sudhakar R ...; Wakchaure, Prasa ...; Chinthakindi, Pr ...; Govender, Thaven ...; Kruger, Hendrick ...; show more...; Naicker, Tricia; Arvidsson, Per I ...; show less...

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